Age-dependent removal of circulating glutathione by rat liver: Role of gamma-glutamyl transferase

AGE ◽  
1992 ◽  
Vol 15 (4) ◽  
pp. 104-107 ◽  
Author(s):  
Hernan Speisky
Keyword(s):  
Rat Liver ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Age Dependent ◽  
Glutamyl Transferase

scholarly journals Role of gamma glutamyl transferase as a diagnostic marker of metabolic syndrome

2019 ◽  
Vol 5 (3) ◽  
pp. 122-126
Author(s):  
Sangamesh Asuti ◽  
◽  
Abhinay Tibdewal ◽  
Arun Narayan ◽  
◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Diagnostic Marker ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Determinants of glutathione efflux and biliary GSH/GSSG ratio in perfused rat liver

1989 ◽  
Vol 256 (3) ◽  
pp. G482-G490 ◽  
Author(s):  
N. Ballatori ◽  
A. T. Truong ◽  
A. K. Ma ◽  
J. L. Boyer
Keyword(s):  
Rat Liver ◽  
Transferase Activity ◽  
Gamma Glutamyl Transferase ◽  
Perfused Rat Liver ◽  
Bicarbonate Buffer ◽  
Gamma Glutamyl ◽  
Fluorocarbon Emulsion ◽  
Glutamyl Transferase ◽  
O2 Delivery ◽  
Sinusoidal Efflux

Utilizing the isolated perfused rat liver, we examined several factors influencing efflux of glutathione [reduced glutathione (GSH) and glutathione disulfide (GSSG)] into perfusate and bile, including the effects of perfusate composition, oxygen delivery to the liver, and acivicin (AT-125), an inhibitor of gamma-glutamyl transferase activity. When livers were perfused with a recirculating Krebs-Ringer bicarbonate buffer only 7-26% of released glutathione was excreted into bile, mainly in its oxidized form (71-90% as GSSG). In contrast, when 20% bovine red blood cells or 20% fluorocarbon emulsion were utilized as perfusates, biliary glutathione accounted for a larger fraction of total hepatic efflux (16-41%), and only 39-65% was excreted as GSSG. To determine whether O2 delivery to the liver could explain some of these differences, biliary and sinusoidal efflux of glutathione were measured as O2 delivery was varied by 1) increasing the perfusion flow rate, 2) altering the concentration of fluorocarbon emulsion (5, 10, and 20%), and 3) changing the PO2 (95% O2-5% CO2 vs. 50% O2-5% CO2-45% N2). Under all experimental conditions, an increase in O2 delivery was accompanied by an increase in bile flow and in the concentration and rate of glutathione efflux into bile but no significant change in sinusoidal efflux of glutathione. Hepatic tissue GSH and GSSG levels were not affected by the various treatments. When gamma-glutamyl transferase activity was inhibited with AT-125, biliary glutathione increased to levels of approximately 50% of total hepatic efflux in fluorocarbon-perfused livers, and only 24-29% of the glutathione was excreted as GSSG.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Role of C-reactive protein and gamma-glutamyl transferase in the diagnosis of metabolic syndrome

2021 ◽  
Vol 9 (4) ◽  
pp. 118-124
Author(s):  
Rubina Ghani ◽  
◽  
Mozaffer Rahim Hingorjo ◽  
Samia Perwaiz Khan ◽  
Uzma Naseeb ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
General Population ◽  
Gamma Glutamyl Transferase ◽  
C Reactive Protein ◽  
Gamma Glutamyl ◽  
Reactive Protein ◽  
Increased Risk ◽  
Glutamyl Transferase

Previous studies have reported that metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events and levels of C-Reactive protein (CRP) can be considered as markers of MetS and its constituent components. Oxidative stress plays a major role in the development of MetS, and levels of gamma-glutamyl transferase (GGT) change with response to oxidative stress are also associated with MetS, which may be modulated by CRP. This study was conducted to identify the role of GGT and CRP as biomarkers in the diagnosis of MetS, a high-risk factor for cardiovascular diseases. One hundred and fifty patients meeting the diagnostic criteria of MetS and an equal number of controls were included in the study. The cases were selected from pathology and molecular biology laboratories, Karachi, while the controls came from the general population. Anthropometric indices of adiposity and blood pressure were recorded for both cases and controls. Blood samples were taken from all subjects to determine the levels of CRP and GGT. All those cases and control height, weight, hip waist circumference were noted and the comparison of CRP and GGT by applying students' t-test as markers for detection of metabolic syndrome. p-value 0.001 was considered as significant. This study suggests that in patients with metabolic syndrome were found to have raised the basal metabolic rate, C-reactive protein and GGT were synergistically associated with MetS independently of another confounding factor in the general population. Keywords: C-reactive protein (CRP), gama glutamyl transferase (GGT), metabolic syndrome, (Met-S), inflammation, body mass index.

Mo-P1:116 Gamma-glutamyl transferase levels are associated to carotid intima-media thickness

2006 ◽  
Vol 7 (3) ◽  
pp. 71-72
Author(s):  
M. Ferraro ◽  
S. La Carrubba ◽  
G. Barone ◽  
V. Spagnuolo ◽  
G. Mauro
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Media Thickness ◽  
Glutamyl Transferase
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