Chiral separations of metoprolol and some analogs with carbon dioxide on chiralcel OD and chiralpak AD stationary phases. Use of chemometrics

2000 ◽  
Vol 51 (5-6) ◽  
pp. 283-293 ◽  
Author(s):  
S. Svensson ◽  
A. Karlsson ◽  
O. Gyllenhaal ◽  
J. Vessman
Keyword(s):  
Carbon Dioxide ◽  
Stationary Phases ◽  
Chiral Separations ◽  
Chiralcel Od

Enantioseparation of 3α-acyloxy-6β-acetoxyltropane compounds with Chiralpak AD and Chiralcel OD-H chiral stationary phases

2015 ◽  
Vol 33 (6) ◽  
pp. 647
Author(s):  
Bin CHENG ◽  
Yifan XIE ◽  
Youmin HU ◽  
Huizhong LIU ◽  
Yinyao NIU ◽  
...  
Keyword(s):  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Chiralcel Od

scholarly journals Recent Advances in Chiral Analysis of Proteins and Peptides

Separations ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 112
Author(s):  
Marine Morvan ◽  
Ivan Mikšík
Keyword(s):  
Amino Acids ◽  
Stationary Phases ◽  
Enzymatic Digestion ◽  
Chiral Separations ◽  
Biological Compounds ◽  
Health And Disease ◽  
Electrophoretic Techniques ◽  
A Site ◽  
Future Work ◽  
Proteins And Peptides

Like many biological compounds, proteins are found primarily in their homochiral form. However, homochirality is not guaranteed throughout life. Determining their chiral proteinogenic sequence is a complex analytical challenge. This is because certain D-amino acids contained in proteins play a role in human health and disease. This is the case, for example, with D-Asp in elastin, β-amyloid and α-crystallin which, respectively, have an action on arteriosclerosis, Alzheimer's disease and cataracts. Sequence-dependent and sequence-independent are the two strategies for detecting the presence and position of D-amino acids in proteins. These methods rely on enzymatic digestion by a site-specific enzyme and acid hydrolysis in a deuterium or tritium environment to limit the natural racemization of amino acids. In this review, chromatographic and electrophoretic techniques, such as LC, SFC, GC and CE, will be recently developed (2018–2020) for the enantioseparation of amino acids and peptides. For future work, the discovery and development of new chiral stationary phases and derivatization reagents could increase the resolution of chiral separations.

Chromatography with Dynamically Created Liquid “Stationary” Phases:  Methanol and Carbon Dioxide

2003 ◽  
Vol 75 (14) ◽  
pp. 3557-3562 ◽  
Author(s):  
Z. Luo ◽  
Y. Xiong ◽  
J. F. Parcher
Keyword(s):  
Carbon Dioxide ◽  
Stationary Phases

Monomeric and polymeric chiral surfactants as pseudo-stationary phases for chiral separations

1997 ◽  
Vol 18 (6) ◽  
pp. 853-872 ◽  
Author(s):  
Shahab A. Shamsi ◽  
Isiah M. Warner
Keyword(s):  
Stationary Phases ◽  
Chiral Separations ◽  
Chiral Surfactants

Memory effect of diethylamine mobile phase additive on chiral separations on polysaccharide stationary phases

Chirality ◽  
2004 ◽  
Vol 16 (8) ◽  
pp. 493-498 ◽  
Author(s):  
Rodger W. Stringham ◽  
Kenneth G. Lynam ◽  
Barbara S. Lord
Keyword(s):  
Memory Effect ◽  
Mobile Phase ◽  
Stationary Phases ◽  
Chiral Separations ◽  
Mobile Phase Additive

Synthesis and Characteristic of Molecularly Imprinted Polymer Immobilized Mesoporous Silica Sphere for Selective Binding of S-Naproxen

2008 ◽  
Vol 47-50 ◽  
pp. 890-893
Author(s):  
Nai Ci Bing ◽  
Zhen Tian ◽  
Sheng Wen Chen ◽  
Qing Hua Li ◽  
Zheng Liang Xu
Keyword(s):  
Mesoporous Silica ◽  
Binding Capacity ◽  
Stationary Phases ◽  
Chiral Separations ◽  
Silica Sphere ◽  
Template Molecule ◽  
Structural Morphology ◽  
Molecularly Imprinted ◽  
Surface Imprinting Technique ◽  
Mesoporous Silica Sphere

Molecularly imprinted composite materials (PM) selective to S-naproxen were prepared in the surface of mesoporous silica sphere (SBA-15) by surface imprinting technique. FT-IR, SEM and surface area analysis were used to study the structural morphology of PM and MIPs particles and probe the incorporation of polymer into the SBA-15 framework. The results revealed that PM showed better binding affinity and selectivity to the template molecule than MIPs and the maximum saturated binding capacity of PM to S-naproxen and R-naproxen was about 10.3332 and 6.0063µmol·g-1. Meanwhile, we achieve a reference strategy for the development of molecularly imprinting polymer for drugs and to handle forms in certain applications such as chromatographic stationary phases for chiral separations.

Sign in / Sign up

Export Citation Format

Share Document