Maximum lipid reduction by partial lleal bypass: A test of the lipid-atherosclerosis hypothesis

Lipids ◽  
1977 ◽  
Vol 12 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Henry Buchwald ◽  
Richard B. Moore ◽  
Richard L. Varco
Keyword(s):  
Lipid Reduction

scholarly journals Bertholletia excelsa Seeds Reduce Anxiety-Like Behavior, Lipids, and Overweight in Mice

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3212
Author(s):  
Oswaldo Frausto-González ◽  
Claudia J. Bautista ◽  
Fernando Narváez-González ◽  
Alberto Hernandez-Leon ◽  
Erika Estrada-Camarena ◽  
...  
Keyword(s):  
Body Weight ◽  
Body Weight Gain ◽  
Chronic Administration ◽  
Testicular Tissue ◽  
Lipid Lowering ◽  
Bertholletia Excelsa ◽  
Calorie Diet ◽  
Hole Board ◽  
Lipid Reduction ◽  
Hypercaloric Diet

Overweight, obesity, and psychiatric disorders are serious health problems. To evidence the anxiolytic-like effects and lipid reduction in mice receiving a high-calorie diet and Bertholletia excelsa seeds in a nonpolar extract (SBHX, 30 and 300 mg/kg), animals were assessed in open-field, hole-board, and elevated plus-maze tests. SBHX (3 and 10 mg/kg) potentiated the pentobarbital-induced hypnosis. Chronic administration of SBHX for 40 days was given to mice fed with a hypercaloric diet to determine the relationship between water and food intake vs. changes in body weight. Testes, epididymal white adipose tissue (eWAT), and liver were dissected to analyze fat content, triglycerides, cholesterol, and histological effects after administering the hypercaloric diet and SBHX. Fatty acids, such as palmitoleic acid (0.14%), palmitic acid (21.42%), linoleic acid (11.02%), oleic acid (59.97%), and stearic acid (7.44%), were identified as constituents of SBHX, producing significant anxiolytic-like effects and preventing body-weight gain in mice receiving the hypercaloric diet without altering their water or food consumption. There was also a lipid-lowering effect on the testicular tissue and eWAT and a reduction of adipocyte area in eWAT. Our data evidence beneficial properties of B. excelsa seeds influencing global health concerns such as obesity and anxiety.

scholarly journals Ongoing clinical trials of lipid reduction therapy in patients with renal disease

1999 ◽  
Vol 56 ◽  
pp. S141-S143 ◽  
Author(s):  
Susumu Yukawa ◽  
Masatoshi Mune ◽  
Yoichi Yamada ◽  
Haruhisa Otani ◽  
Masanori Kishino ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Renal Disease ◽  
Lipid Reduction

Endothelial (dys)Function, Lipid Reduction and Balloon Angioplasty

1997 ◽  
pp. 55-82 ◽  
Author(s):  
Han J. G. H. Mulder ◽  
Martin J. Schalij
Keyword(s):  
Balloon Angioplasty ◽  
Lipid Reduction

scholarly journals Short bowel syndrome in infancy: recent advances and practical management

2020 ◽  
pp. flgastro-2020-101457
Author(s):  
Elena Cernat ◽  
Chloe Corlett ◽  
Natalia Iglesias ◽  
Nkem Onyeador ◽  
Julie Steele ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Short Bowel Syndrome ◽  
Intestinal Adaptation ◽  
Intestinal Failure ◽  
Rare Condition ◽  
Oral Feeding ◽  
Short Bowel ◽  
Intestinal Continuity ◽  
Gastrointestinal Reconstruction ◽  
Lipid Reduction

Short bowel syndrome (SBS) is a rare condition characterised by extensive loss of intestinal mass secondary to congenital or acquired disease. The outcomes are determined by dependency on parenteral nutrition (PN), its possible complications and factors that influence intestinal adaptation. In order to achieve the best results, patients should be managed by a specialised multidisciplinary team with the aims of promoting growth and development, stimulating intestinal adaptation and preventing possible complications. This involves timely surgical management aimed at rescuing maximum bowel length and eventually re-establishing intestinal continuity where appropriate. A combination of enteral and parenteral nutrition needs to be targeted towards maintaining a balance between fulfilling the nutritional and metabolic needs of the child while preventing or at least minimising potential complications. Enteral nutrition and establishment of oral feeding play a fundamental role in stimulating bowel adaptation and promoting enteral autonomy. Other measures to promote enteral autonomy include the chyme recycling in patients where bowel is not in continuity, autologous gastrointestinal reconstruction and pharmacological treatments, including promising new therapies like teduglutide. Strategies such as lipid reduction, changing the type of lipid emulsion and cycling PN are associated with a reduction in the rates of intestinal failure–associated liver disease. Even though vast improvements have been made in the surgical and medical management of SBS, there is still lack of consensus in many aspects and collaboration is essential.

1 Carotid plaque lipid reduction, determined by T2 mapping, occurs early after high-intensity statin initiation in patients presented with acute myocardial infarction

2018 ◽  
Author(s):  
Mohammad Alkhalil ◽  
Luca Biasiolli ◽  
Naveed Akbar ◽  
Francesca Galassi ◽  
Joshua T Chai ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
High Intensity ◽  
Carotid Plaque ◽  
T2 Mapping ◽  
Lipid Reduction

scholarly journals A Comparison of Ezetimibe and Evolocumab for Atherogenic Lipid Reduction in Four Patient Populations: A Pooled Efficacy and Safety Analysis of Three Phase 3 Studies

2020 ◽  
Vol 9 (2) ◽  
pp. 447-465
Author(s):  
Michael J. Koren ◽  
Peter H. Jones ◽  
Jennifer G. Robinson ◽  
David Sullivan ◽  
Leslie Cho ◽  
...  
Keyword(s):  
Safety Analysis ◽  
Efficacy And Safety ◽  
Phase 3 ◽  
Three Phase ◽  
Lipid Reduction ◽  
Atherogenic Lipid

Comments on Lipid Reduction After Myocardial Infarction

1988 ◽  
Vol 12 ◽  
pp. S97-99
Author(s):  
Lars Wilhelmsen
Keyword(s):  
Myocardial Infarction ◽  
Lipid Reduction

Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab

2017 ◽  
Vol 376 (16) ◽  
pp. 1517-1526 ◽  
Author(s):  
Paul M Ridker ◽  
Jean-Claude Tardif ◽  
Pierre Amarenco ◽  
William Duggan ◽  
Robert J. Glynn ◽  
...  
Keyword(s):  
Antibody Formation ◽  
Antidrug Antibody ◽  
Lipid Reduction
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