Positional isomers of unsaturated fatty acids in rat liver lipids

Lipids ◽  
1977 ◽  
Vol 12 (3) ◽  
pp. 307-313 ◽  
Author(s):  
Brigitte Schmitz ◽  
Uwe Murawski ◽  
Manfred Pflüger ◽  
Heinz Egge
Keyword(s):  
Fatty Acids ◽  
Rat Liver ◽  
Unsaturated Fatty Acids ◽  
Positional Isomers ◽  
Liver Lipids

Ozonolysis of unsaturated fatty acids. II. Esterification of the total products from the oxidative decomposition of ozonides with 2,2-dimethoxypropane

1967 ◽  
Vol 45 (13) ◽  
pp. 1405-1410 ◽  
Author(s):  
John D. Castell ◽  
R. G. Ackman
Keyword(s):  
Fatty Acids ◽  
Liquid Chromatography ◽  
Unsaturated Fatty Acids ◽  
Performic Acid ◽  
Acid Oxidation ◽  
Gas Liquid Chromatography ◽  
Positional Isomers ◽  
Flame Ionization ◽  
Hydrogen Flame

The total acidic products from the performic acid oxidation of the ozonide of methyl oleate formed in methanol may be esterified directly in a few hours with 2,2-dimethoxypropane. The ester concentrations are adequate for the determination of the positional isomers of monoethylenic fatty acids directly from the reaction mixture, using a hydrogen flame ionization gas–liquid chromatography detector. Dimethyl sulfoxide was not required to prevent the breakdown of 2,2-dimethoxypropane under the conditions employed.

In vivo incorporation of labeled fatty acids in rat liver lipids after oral administration

Lipids ◽  
1987 ◽  
Vol 22 (8) ◽  
pp. 553-558 ◽  
Author(s):  
J. Leyton ◽  
P. J. Drury ◽  
M. A. Crawford
Keyword(s):  
Fatty Acids ◽  
Oral Administration ◽  
Rat Liver ◽  
Liver Lipids

scholarly journals Unsaturated Fatty Acids Associated with Glycogen May Inhibit Glucose-6 Phosphatase in Rat Liver

1997 ◽  
Vol 127 (12) ◽  
pp. 2289-2292 ◽  
Author(s):  
Nathalie Danièle ◽  
Jean-Claude Bordet ◽  
Gilles Mithieux
Keyword(s):  
Fatty Acids ◽  
Rat Liver ◽  
Unsaturated Fatty Acids

scholarly journals Fatty acid metabolism in the perfused rat liver

1970 ◽  
Vol 119 (3) ◽  
pp. 525-533 ◽  
Author(s):  
H. A. Krebs ◽  
R. Hems
Keyword(s):  
Fatty Acids ◽  
Rat Liver ◽  
Ketone Body ◽  
Unsaturated Fatty Acids ◽  
Ketone Bodies ◽  
Saturated Fatty Acids ◽  
Perfused Rat Liver ◽  
Body Formation ◽  
Body Production ◽  
Chain Fatty Acids

1. The formation of acetoacetate, β-hydroxybutyrate and glucose was measured in the isolated perfused rat liver after addition of fatty acids. 2. The rates of ketone-body formation from ten fatty acids were approximately equal and independent of chain length (90–132μmol/h per g), with the exception of pentanoate, which reacted at one-third of this rate. The [β-hydroxybutyrate]/[acetoacetate] ratio in the perfusion medium was increased by long-chain fatty acids. 3. Glucose was formed from all odd-numbered fatty acids tested. 4. The rate of ketone-body formation in the livers of rats kept on a high-fat diet was up to 50% higher than in the livers of rats starved for 48h. In the livers of fat-fed rats almost all the O2 consumed was accounted for by the formation of ketone bodies. 5. The ketone-body concentration in the blood of fat-fed rats rose to 4–5mm and the [β-hydroxybutyrate]/[acetoacetate] ratio rose to 11.5. 6. When the activity of the microsomal mixed-function oxidase system, which can bring about ω-oxidation of fatty acids, was induced by treatment of the rat with phenobarbitone, there was no change in the ketone-body production from fatty acids, nor was there a production of glucose from even-numbered fatty acids. The latter would be expected if ω-oxidation occurred. Thus ω-oxidation did not play a significant role in the metabolism of fatty acids. 7. Arachidonate was almost quantitatively converted into ketone bodies and yielded no glucose, demonstrating that gluconeogenesis from poly-unsaturated fatty acids with an even number of carbon atoms does not occur. 8. The rates of ketogenesis from unsaturated fatty acids (sorbate, undecylenate, crotonate, vinylacetate) were similar to those from the corresponding saturated fatty acids. 9. Addition of oleate together with shorter-chain fatty acids gave only a slightly higher rate of ketone-body formation than oleate alone. 10. Glucose, lactate, fructose, glycerol and other known antiketogenic substances strongly inhibited endogenous ketogenesis but had no effects on the rate of ketone-body formation in the presence of 2mm-oleate. Thus the concentrations of free fatty acids and of other oxidizable substances in the liver are key factors determining the rate of ketogenesis.

EFFECT OF UNSATURATED FATTY ACIDS ON DRUG HYDROXYLATION AND CONJUGATION IN THE RAT LIVER

Abstracts ◽  
1977 ◽  
pp. 394
Author(s):  
Matti Lang ◽  
Matti Laitinen ◽  
Eino Hietanen
Keyword(s):  
Fatty Acids ◽  
Rat Liver ◽  
Unsaturated Fatty Acids ◽  
Drug Hydroxylation

Synthesis of Unsaturated Fatty Acids. Positional Isomers of Linoleic Acid1

1963 ◽  
Vol 28 (5) ◽  
pp. 1254-1259 ◽  
Author(s):  
Walter J. Gensler ◽  
John J. Bruno
Keyword(s):  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Positional Isomers

Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice

2015 ◽  
Vol 26 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Kazuaki Yoshinaga ◽  
Keiichi Sasaki ◽  
Hiroyuki Watanabe ◽  
Koji Nagao ◽  
Nao Inoue ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Unsaturated Fatty Acids ◽  
Positional Isomers ◽  
Highly Unsaturated Fatty Acids ◽  
Differential Effects
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