Altered fatty acid desaturation and microsomal fatty acid composition in the streptozotocin diabetic rat

Lipids ◽  
1980 ◽  
Vol 15 (11) ◽  
pp. 953-961 ◽  
Author(s):  
Fred H. Faas ◽  
William J. Carter
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Fatty Acid Desaturation ◽  
Diabetic Rat ◽  
Streptozotocin Diabetic Rat

The fatty acid composition of glycerolipids in nerve, brain, and other tissues of the streptozotocin diabetic rat

1985 ◽  
Vol 10 (11) ◽  
pp. 1453-1465 ◽  
Author(s):  
Chorng-Jly Lin ◽  
Richard Peterson ◽  
Joseph Eichberg
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Diabetic Rat ◽  
Streptozotocin Diabetic Rat

scholarly journals Fatty-acid desaturation and microsomal lipid fatty-acid composition in experimental hyperthyroidism

1981 ◽  
Vol 193 (3) ◽  
pp. 845-852 ◽  
Author(s):  
F H Faas ◽  
W J Carter
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Food Intake ◽  
Acid Composition ◽  
Unsaturated Fatty Acids ◽  
Fatty Acid Desaturation ◽  
Experimental Hyperthyroidism ◽  
Lipid Fatty Acid ◽  
Hormone Effect ◽  
Lipid Fatty Acid Composition

We have studied the influence of experimental hyperthyroidism in the rat on the synthesis of unsaturated fatty acids and on liver microsomal lipid fatty-acid composition. Tri-iodothyronine treatment (25 micrograms/100 g body weight) daily for 3 weeks caused no significant changes in delta 9 (stearate) desaturation but a 24% decrease in delta 6 (linoleate) desaturation. Much larger doses of tri-iodothyronine increased delta 9 desaturation. Liver microsomal fatty-acid composition in hyperthyroidism is altered with significantly increased proportions of stearate and arachidonate and decreased proportions of palmitate, palmitoleate, linoleate (C18:2) and eicosa-8,11,14-trienoate (C20:3). These changes, other than the decreases proportion of C20:3 fatty acid, which may be due to the diminished delta 6 desaturase activity, cannot be attributed to changes in fatty-acid desaturation. Most of these changes were also found to be due not simply to the decreased weight gain or the increased food intake of the hyperthyroid animals. Only the decreased C18:2 fatty-acid proportions could be mimicked by restricting food intake of control animals and none of the changes were prevented by restricting food intake of hyperthyroid animals. Thus most of the changes in microsomal lipid fatty-acid composition are likely to be due to a thyroid hormone effect on peripheral lipid mobilization or lipid degradation.

Altered fatty acid composition in the plasma, platelets, and aorta of the streptozotocin-induced diabetic rat

Metabolism ◽  
1988 ◽  
Vol 37 (11) ◽  
pp. 1065-1072 ◽  
Author(s):  
A.Q. Dang ◽  
F.H. Faas ◽  
J.A. Lee ◽  
W.J. Carter
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Diabetic Rat

Tissue phospholipid fatty acid composition in the diabetic rat

Lipids ◽  
1984 ◽  
Vol 19 (5) ◽  
pp. 367-370 ◽  
Author(s):  
Y. S. Huang ◽  
D. F. Horrobin ◽  
M. S. Manku ◽  
J. Mitchell ◽  
M. A. Ryan
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Phospholipid Fatty Acid ◽  
Diabetic Rat ◽  
Phospholipid Fatty Acid Composition ◽  
Tissue Phospholipid

scholarly journals Fatty Acid Composition in 1,2-Diacylglycerol of Diabetic and Insulin-Treated Diabetic Rat Hearts.

1991 ◽  
Vol 32 (5) ◽  
pp. 667-673 ◽  
Author(s):  
Kenji OKUMURA ◽  
Takuya NISHIURA ◽  
Kiyokazu SHIMIZU ◽  
Yoshio IWAMA ◽  
Junichiro KONDO ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Diabetic Rat ◽  
Rat Hearts

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

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