An indirect method for continuous registration of cardiac output from hemodynamic parameters

1982 ◽  
Vol 394 (S1) ◽  
pp. R9-R9
Author(s):  
H. Korb ◽  
A. Hoeft ◽  
D. Baller ◽  
R. Schräder ◽  
H. G. Wolpers ◽  
...  

1994 ◽  
Vol 3 (5) ◽  
pp. 382-386 ◽  
Author(s):  
CL Ostrow ◽  
E Hupp ◽  
D Topjian

BACKGROUND: Although we have insufficient knowledge about the effects of Trendelenburg positions on various hemodynamic parameters, these positions are frequently used to influence cardiac output and blood pressure in critically ill patients. OBJECTIVES: To determine the effect of Trendelenburg and modified Trendelenburg positions on five dependent variables: cardiac output, cardiac index, mean arterial pressure, systemic vascular resistance, and oxygenation in critically ill patients. METHODS: In this preliminary study subjects were 23 cardiac surgery patients (mean age, 55; SD, 8.09) who had a pulmonary artery catheter for cardiac output determination and who were clinically stable, normovolemic and normotensive. Baseline measurements of the dependent variables were taken in the supine position. Patients were then placed in 10 degrees Trendelenburg or 30 degrees modified Trendelenburg position. The dependent variables were measured after 10 minutes in each position. A 2-period, 2-treatment crossover design with a preliminary baseline measurement was used. RESULTS: Five subjects were unable to tolerate Trendelenburg position because of nausea or pain in the sternal incision. In the 18 who were able to tolerate both position changes, no statistically significant changes were found in the five dependent variables. Changes in systemic vascular resistance over time approached statistical significance and warrant further study. CONCLUSIONS: This preliminary study does not provide support for Trendelenburg positions as a means to influence hemodynamic parameters such as cardiac output and blood pressure in normovolemic and normotensive patients.



1995 ◽  
Vol 18 (9) ◽  
pp. 499-503 ◽  
Author(s):  
F. Pizzarelli ◽  
P. Dattolo ◽  
M. Piacenti ◽  
M.A. Morales ◽  
T. Cerrai ◽  
...  

We studied in 13 hemodialysis patients intradialytic variations of blood volume (BV) and cardiac output, by means of non-invasive methods. We found a weak correlation, r 0.2 or less, between BV variations and intradialysis blood pressure variations. The sensitivity of the former in describing the variations of the latter was only 32%. During the 30 min preceeding the hypotensive crisis the percent BV variations did not show any predictive trend. On the contrary, refilling increased as blood pressure dropped and a weak inverse relation (r -0.35) was found between these two parameters. Unstable patients had predialytic blood volume values significantly lower than stable ones and comparable to healthy subjects. On the contrary, the correlation between percent variations of cardiac output index and MAP was 0.68 with a sensitivity and specificity of 90% and 59%, respectively. Unfortunately these promising results were obtained only with an estimate of cardiac output obtained by echocardiography and not by transthoracic impedance cardiography, which is much more feasible than the former as on-line monitoring of cardiac output. On-line monitoring of hemodynamic parameters is an appealing but still unsolved task.



1963 ◽  
Vol 41 (11) ◽  
pp. 2337-2341 ◽  
Author(s):  
Elwood W. Speckmann ◽  
Robert K. Ringer

The cardiac output of untreated mature male Broad Breasted Bronze (BBB) turkeys was determined by an isotope dilution technique using radioactive phosphorus (P32). A Geiger–Mueller tube was connected to a rate meter which in turn was connected to a moving graph to continuously record the indicator concentration, thus obtaining the initial dilution curve. Posterior tibial and common carotid arterial blood pressures were measured directly and were recorded simultaneously with the cardiac output determinations by means of two strain gauges connected to a recording polygraph.From the cardiovascular measurements systemic resistance was calculated. The mean cardiac output of the mature male BBB turkey was 231 ml per kg body weight0.734 per minute. The mean carotid hemodynamic parameters were: systolic BP, 302 mm Hg; diastolic BP, 204 mm Hg; and pulse pressure, 98 mm Hg. Heart rate was 149 beats per minute. The mean tibial hemodynamic parameters were; systolic BP, 286 mm Hg; diastolic BP, 200 mm Hg; and pulse pressure, 85 mm Hg. The mean systemic resistance units were 0.17 and 0.16 for carotid and tibial arteries respectively on a bird basis and 1.13 and 1.08 respectively per kg body weight0.734.



1963 ◽  
Vol 41 (1) ◽  
pp. 2337-2341 ◽  
Author(s):  
Elwood W. Speckmann ◽  
Robert K. Ringer

The cardiac output of untreated mature male Broad Breasted Bronze (BBB) turkeys was determined by an isotope dilution technique using radioactive phosphorus (P32). A Geiger–Mueller tube was connected to a rate meter which in turn was connected to a moving graph to continuously record the indicator concentration, thus obtaining the initial dilution curve. Posterior tibial and common carotid arterial blood pressures were measured directly and were recorded simultaneously with the cardiac output determinations by means of two strain gauges connected to a recording polygraph.From the cardiovascular measurements systemic resistance was calculated. The mean cardiac output of the mature male BBB turkey was 231 ml per kg body weight0.734 per minute. The mean carotid hemodynamic parameters were: systolic BP, 302 mm Hg; diastolic BP, 204 mm Hg; and pulse pressure, 98 mm Hg. Heart rate was 149 beats per minute. The mean tibial hemodynamic parameters were; systolic BP, 286 mm Hg; diastolic BP, 200 mm Hg; and pulse pressure, 85 mm Hg. The mean systemic resistance units were 0.17 and 0.16 for carotid and tibial arteries respectively on a bird basis and 1.13 and 1.08 respectively per kg body weight0.734.



1974 ◽  
Vol 67 (1) ◽  
pp. 49-53 ◽  
Author(s):  
H. A. FERRARI ◽  
R. J. GORTEN ◽  
I. H. TALTON ◽  
R. CANENT ◽  
J. K. GOODRICH


2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
R Kazimierczyk ◽  
P Szumowski ◽  
P Blaszczak ◽  
E Kazimierczyk ◽  
K Ptaszynska-Kopczynska ◽  
...  

Abstract Background Right ventricular (RV) function is a major determinant of survival in patients with pulmonary arterial hypertension (PAH). The concept of coupling mainly refers to the relationship between ventricular contractility and afterload. In advanced PAH, to maintain cardiac output, RV dilates and the uncoupling occurs with wall stress and increased metabolic demand. We previously confirmed that impaired RV function is associated with increased glucose uptake of RV myocytes estimated by PET, which marks patients with worse prognosis. Purpose Whether echocardiographic approach of coupling parameters in PAH patients has relationship with RV metabolic alterations. Methods Twenty-six stable PAH patients (mean age 49.92 ± 15.94 years) and sixteen healthy subjects (control group) were enrolled into the study. The TAPSE, reflecting RV contractility, was obtained by mono-dimensional echo in standard technique. The echo estimation of the sPAP was reflecting RV afterload. Ventricular-arterial coupling was evaluated by the ratio between those two parameters. All PAH patients had also right heart catheterization (RHC) and PET performed during baseline visit. Heart glucose metabolism was assessed with fluorodeoxyglucose (FDG) as a tracer in PET. Its uptake was quantified as mean standardized uptake value (SUV) for both left ventricle (LV) and RV. Mean follow-up time of this study was 16.6 ± 7.5 months and the clinical end-point (CEP) was defined as death or clinical deterioration. Results Most of enrolled patients were in the WHO functional Class III (61%, 16). There were significant correlations between echo-derived hemodynamic parameters and RHC-derived values e.g. emPAP vs mPAP (RHC), r = 0.86, p < 0.001. Echo-estimated RV ventricular-arterial coupling parameter (TAPSE/sPAP) was 0.35 ± 0.20 in PAH group and 1.51 ± 0.22 in control group, p < 0.001. Mean SUV RV/LV ratio was 1.03 ± 0.68 in PAH group and 0.19 ± 0.08 in controls, p < 0.005. Echo-derived TAPSE/sPAP significantly correlated with hemodynamic parameters from RHC – cardiac output and pulmonary vascular resistance. Interestingly, we also observed significant correlations of TAPSE/sPAP with glucose uptake in PET - SUV RV as well as with SUV RV/LV (r=-0.63, p = 0.0006; r=-0.50, p = 0.0009), confirming higher metabolic demand in uncoupled heart in case of PAH. Furthermore, patients who reached CEP (n = 15, 57%) had a significantly lower TAPSE/esPAP ratio (0.29 ± 0.17 vs 0.43 ± 0.21, p = 0.04) and higher SUV RV/LV (1.39 ± 0.79 vs 0.55 ± 0.45, p = 0.01). ROC analysis revealed significant cut-off value of TAPSE/esPAP in predicting CEP (AUC 0.72 (95% CI 0.52-0.92), p = 0.03). Patients with TAPSE/esPAP lower than 0.25 mm/mmHg had worse prognosis, log-rank test, p = 0.001 (Figure 1). Conclusions Simple echocardiographic parameter reflecting RV coupling (TAPSE/esPAP) related to altered myocardium metabolism in PAH may predict outcome in patients with PAH. Abstract 408 Figure 1



1963 ◽  
Vol 113 (3) ◽  
pp. 652-656 ◽  
Author(s):  
R. V. Brink ◽  
R. Rosas ◽  
P. Blaquier ◽  
D. F. Bohr


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