Drug release from the enzyme-degradable and pH-sensitive hydrogel composed of glycidyl methacrylate dextran and poly(acrylic acid)

2005 ◽  
Vol 28 (8) ◽  
pp. 983-987 ◽  
Author(s):  
In-Sook Kim ◽  
In-Joon Oh
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Glycidyl Methacrylate ◽  
Ph Sensitive ◽  
Ph Sensitive Hydrogel ◽  
Poly Acrylic Acid

scholarly journals pH-Sensitive Polyampholyte Microgels of Poly(Acrylic Acid-co-Vinylamine) as Injectable Hydrogel for Controlled Drug Release

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 285 ◽  
Author(s):  
Yanmin Chen ◽  
Peijian Sun
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Zeta Potential ◽  
Suspension Polymerization ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Swelling Ratio ◽  
Sustained Drug Release ◽  
Injectable Hydrogel ◽  
Poly Acrylic Acid

pH-sensitive polyampholyte microgels of poly(acrylic acid-co-vinylamine) (P(AA-co-VAm)) were developed as an injectable hydrogel for controlled drug release. The microgels of P(AA-co-VAm) were prepared via inverse suspension polymerization of acrylic acid and N-vinylformamide followed by hydrolysis of poly(N-vinylformamide) (PNVF) chains of the resultant microgels under basic condition. The pH-sensitivity of the P(AA-co-VAm) microgels in zeta potential and swelling ratio were investigated using a zeta potential analyzer and optical microscope. The results showed that both the zeta potential and the swelling ratio of the microgels were highly affected by the solution pH. By changing the pH of P(AA-co-VAm) microgel dispersion, the interparticle interaction and the swelling ratio of the microgels could be well adjusted and a colloidal hydrogel could be fabricated at moderate pH, showing a pH-triggered reversible fluid-gel transition. Using the polyampholyte P(AA-co-VAm) microgels as an injectable hydrogel drug release system, a sustained drug release could be achieved, indicating the great potentials of the pH-sensitive P(AA-co-VAm) microgels for controlled drug delivery.

Preparation and characterization of pH-sensitive hydrogel of chitosan/poly(acrylic acid) co-polymer

2004 ◽  
Vol 15 (4) ◽  
pp. 465-474 ◽  
Author(s):  
Lili Shi ◽  
Liming Yang ◽  
Jie Chen ◽  
Yong Pei ◽  
Min Chen ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Ph Sensitive ◽  
Ph Sensitive Hydrogel ◽  
Poly Acrylic Acid

Preparation and Characterization of pH-sensitive Hydrogel Film of Chitosan/Poly(acrylic acid) Copolymer

2005 ◽  
Vol 225 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Liming Yang ◽  
Lili Shi ◽  
Jie Chen ◽  
Yong Pei ◽  
Feng Zhu ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Ph Sensitive ◽  
Hydrogel Film ◽  
Acid Copolymer ◽  
Acrylic Acid Copolymer ◽  
Ph Sensitive Hydrogel ◽  
Poly Acrylic Acid

scholarly journals pH Sensitive Hydrogel Based on Poly(Acrylic Acid) and Cellulose Nanocrystals

2015 ◽  
Vol 44 (6) ◽  
pp. 779-785 ◽  
Author(s):  
Lim Sze Lim ◽  
Ishak Ahmad ◽  
Azwan Mat Lazim
Keyword(s):  
Acrylic Acid ◽  
Cellulose Nanocrystals ◽  
Ph Sensitive ◽  
Ph Sensitive Hydrogel ◽  
Poly Acrylic Acid

Development of a facile one-pot synthesis method for an ingestible pH sensitive actuator

MRS Advances ◽  
2019 ◽  
Vol 5 (17) ◽  
pp. 881-889
Author(s):  
Alex Keller ◽  
Holly Warren ◽  
Marc in het Panhuis
Keyword(s):  
Acrylic Acid ◽  
Calcium Hydroxide ◽  
Sodium Citrate ◽  
Synthesis Method ◽  
Gastric Fluid ◽  
Ph Sensitive ◽  
One Pot ◽  
Acidic Environments ◽  
Printed Materials ◽  
Poly Acrylic Acid

ABSTRACTEdible devices are an emergent technology and in this paper the simplicity and efficacy that poly(acrylic acid)/calcium hydroxide possess in creating a pH sensitive ingestible actuator which responds to acidic environments such as gastric fluid is demonstrated. It was found that poly(acrylic acid)/calcium hydroxide hydrogels exhibit reversible actuation upon submerging in 0.1 M sodium citrate for 2 hours. Our results show that these hydrogels can restore their compressive stress to 0.19 ± 0.06 MPa, swelling ratio to 26 ± 2 and volume to 56% ± 3% of its original volume. This work offers new possibilities for developments in a variety of fields such as drug delivery, 4D printed materials, soft robotics and edible devices.

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