pH-sensitive cationic guar gum/poly (acrylic acid) polyelectrolyte hydrogels: Swelling and in vitro drug release

2007 ◽  
Vol 69 (4) ◽  
pp. 774-783 ◽  
Author(s):  
Yihong Huang ◽  
Huiqun Yu ◽  
Chaobo Xiao
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Guar Gum ◽  
Ph Sensitive ◽  
In Vitro Drug Release ◽  
Poly Acrylic Acid

scholarly journals Methionine as a Spacer between Poly Acrylic acid and Ampicillin

2015 ◽  
Vol 12 (3) ◽  
pp. 563-571
Author(s):  
Baghdad Science Journal
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Acidic Medium ◽  
Basic Medium ◽  
In Vitro Drug Release ◽  
Release Study ◽  
Novel Drug Delivery System ◽  
Novel Drug ◽  
Poly Acrylic Acid

In this work a novel drug delivery system through modification of poly acrylic acid with Methionine as a spacer between the poly acrylic acid which was converted to its acyl chloride and reacted with Methionine as spacer unit which has been reacted with Ampicillin drug. In vitro drug release study had been conducted successfully in basic medium in pH 7.4 and acidic medium in pH 1.1 at 37?. Due to many problems associated with drug release and, this modification could decrease the side effect of drug. The prepared prodrug polymer was characterized by spectra method [FTIR and 1H?NMR]. Physical properties and intrinsic viscosity of drug polymer were determined. The good results were obtained in the presence of spacer unit with comparing without spacer unit.

scholarly journals Formulation and Evaluation of Sustained Release Matrix Tablets of Aceclofenac

2021 ◽  
Vol 4 (2) ◽  
pp. 99-109
Author(s):  
Priyanka Singh ◽  
Amit Kumar Shrivastava ◽  
Sachin Kumar ◽  
Manish Dhar Dwivedi
Keyword(s):  
Drug Release ◽  
Guar Gum ◽  
Polymer Concentration ◽  
Matrix Tablets ◽  
Hydrophilic Polymers ◽  
Wet Granulation ◽  
Drug Release Profile ◽  
In Vitro Drug Release ◽  
Study Results

This study aimed to improve the dissolution rate of aceclofenac and release the drug in a controlled manner over a period of 24 hours. Matrix tablets were prepared by direct compression method, using hydrophilic polymers (HPMC/guar gum). Matrix tablets were prepared by wet granulation method using different hydrophilic polymers (HPMC/guar gum). Tablets were evaluated for in vitro drug release profile in phosphate buffer with pH 6.8 (without enzymes). The thickness and hardness of prepared tablets were 3.23 ± 0.035 to 3.28 ± 0.008 mm and 3.26 ± 0.115 to 3.60 ± 0.200 kg/cm2, respectively. The friability was within the acceptable limits of pharmacopoeial specifications (0.31 to 0.71%), which indicates the good mechanical strength of the tablets. Drug release was retarded with an increase in polymer concentration due to the gelling property of polymers. The in vitro drug release from the proposed system was best explained by Higuchi’s model, indicating that drug release from tablets displayed a diffusion-controlled mechanism. The results clearly indicate that guar gum could be a potential hydrophilic carrier in developing oral controlled drug delivery systems. Based on the study results, formulations F8 was selected as the best formulation.

Glucosamine-carrying temperature- and pH-sensitive microgels: Preparation, characterization, and in vitro drug release studies

2008 ◽  
Vol 322 (1) ◽  
pp. 333-341 ◽  
Author(s):  
Dayong Teng ◽  
Jingli Hou ◽  
Xinge Zhang ◽  
Xin Wang ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Ph Sensitive ◽  
In Vitro Drug Release ◽  
Release Studies
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