The effects of furosemide on renal blood flow and cortical perfusion during methoxyflurane and halothane anaesthesia

1976 ◽  
Vol 23 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Kenneth M. Leighton ◽  
Caroline Bruce ◽  
Richard Machin
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Halothane Anaesthesia ◽  
Cortical Perfusion

scholarly journals Activation of the cannabinoid receptor 2 increases renal perfusion

2019 ◽  
Vol 51 (3) ◽  
pp. 90-96 ◽  
Author(s):  
J. D. Pressly ◽  
H. Soni ◽  
S. Jiang ◽  
J. Wei ◽  
R. Liu ◽  
...  
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Cannabinoid Receptor ◽  
Renal Perfusion ◽  
Receptor Activation ◽  
Cb2 Receptor ◽  
Renal Vasculature ◽  
Cannabinoid Receptor 2 ◽  
Afferent Arterioles ◽  
Cortical Perfusion

Acute kidney injury (AKI) is an increasing clinical problem that is associated with chronic kidney disease progression. Cannabinoid receptor 2 (CB2) activation has been shown to mitigate some of the deleterious tubular effects due to AKI, but its role on the renal vasculature has not been fully described. In this study, we investigated the effects of our novel CB2 receptor agonist, SMM-295, on renal vasculature by assessing cortical perfusion with laser Doppler flowmetry and changes in luminal diameter with isolated afferent arterioles. In this study, intravenously infused SMM-295 (6 mg/kg) significantly increased cortical renal perfusion (13.8 ± 0.6%; P < 0.0001; n = 7) compared with vehicle (0.1 ± 1.5%; n = 10) normalized to baseline values in anesthetized C57BL/6J mice. This effect was not dependent upon activation of the CB1 receptor (met-anandamide; 6 mg/kg iv) and was predominantly abolished in Cnr2 knockout mice with SMM-295 (6 mg/kg iv). Ablation of the renal afferent nerves with capsaicin blocked the SMM-295-dependent increase in renal cortical perfusion, and the increased renal blood flow was not dependent upon products synthesized by cyclooxygenase or nitric oxide synthase. The increased renal perfusion by CB2 receptor activation is also attributed to a direct vascular effect, since SMM-295 (5 μM) engendered a significant 37 ± 7% increase ( P < 0.0001; n = 4) in luminal diameters of norepinephrine-preconstricted afferent arterioles. These data provide new insight into the potential benefit of SMM-295 by activating vascular and nonvascular CB2 receptors to promote renal vasodilation, and provide a new therapeutic target to treat renal injuries that impact renal blood flow dynamics.

Determination of renal blood flow by thermodilution method

1978 ◽  
Vol 38 (5) ◽  
pp. 495-499 ◽  
Author(s):  
Torbjörn Leivestad ◽  
Erling Brodwall ◽  
Svein Simonsen
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Thermodilution Method

Measurement of Renal Blood Flow by 131I-Labelled Sodium Iodohippurate Imaging in a Rat Model of Herpes Encephalitis

1990 ◽  
Vol 31 (5) ◽  
pp. 538-539
Author(s):  
G. M. Cleator ◽  
P. E. Klapper ◽  
A. G. Lewis ◽  
H. L. Sharma ◽  
A. M. Smith
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Rat Model ◽  
Herpes Encephalitis

Bias and Precision in Magnetic Resonance Imaging‐Based Estimates of Renal Blood Flow: Assessment by Triangulation

2021 ◽  
Author(s):  
Bashair A. Alhummiany ◽  
David Shelley ◽  
Margaret Saysell ◽  
Maria‐Alexandra Olaru ◽  
Bernd Kühn ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Magnetic Resonance ◽  
Renal Blood Flow ◽  
Resonance Imaging

Renal blood flow, early distal sodium, and plasma renin concentrations during osmotic diuresis

2000 ◽  
Vol 279 (4) ◽  
pp. R1268-R1276 ◽  
Author(s):  
Paul P. Leyssac ◽  
Niels-Henrik Holstein-Rathlou ◽  
Ole Skøtt
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Sodium Excretion ◽  
Plasma Renin ◽  
Urine Flow ◽  
Sodium Reabsorption ◽  
Osmotic Diuresis ◽  
Nacl Concentration ◽  
Proximal Tubular ◽  
Distal Tubules

Inconsistencies in previous reports regarding changes in early distal NaCl concentration (EDNaCl) and renin secretion during osmotic diuresis motivated our reinvestigation. After intravenous infusion of 10% mannitol, EDNaCl fell from 42.6 to 34.2 mM. Proximal tubular pressure increased by 12.6 mmHg. Urine flow increased 10-fold, and sodium excretion increased by 177%. Plasma renin concentration (PRC) increased by 58%. Renal blood flow and glomerular filtration rate decreased, however end-proximal flow remained unchanged. After a similar volume of hypotonic glucose (152 mM), EDNaClincreased by 3.6 mM, ( P < 0.01) without changes in renal hemodynamics, urine flow, sodium excretion rate, or PRC. Infusion of 300 μmol NaCl in a smaller volume caused EDNaCl to increase by 6.4 mM without significant changes in PRC. Urine flow and sodium excretion increased significantly. There was a significant inverse relationship between superficial nephron EDNaCl and PRC. We conclude that EDNa decreases during osmotic diuresis, suggesting that the increase in PRC was mediated by the macula densa. The results suggest that the natriuresis during osmotic diuresis is a result of impaired sodium reabsorption in distal tubules and collecting ducts.

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