A study on the influence of preoperative radiotherapy to proliferating cell nuclear antigen (PCNA) for oral cancer cells

1998 ◽  
Vol 86 (1) ◽  
pp. 121-129
Author(s):  
Osamu Munemura ◽  
Masashi Tanaka ◽  
Masayori Shirakawa
Keyword(s):  
Oral Cancer ◽  
Cancer Cells ◽  
Proliferating Cell Nuclear Antigen ◽  
Preoperative Radiotherapy ◽  
Nuclear Antigen ◽  
Oral Cancer Cells ◽  
Proliferating Cell

Generation of an intrabody-based reagent suitable for imaging endogenous proliferating cell nuclear antigen in living cancer cells

2014 ◽  
Vol 27 (9) ◽  
pp. 549-558 ◽  
Author(s):  
Guillaume Freund ◽  
Dominique Desplancq ◽  
Audrey Stoessel ◽  
Robin Weinsanto ◽  
Annie-Paule Sibler ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Proliferating Cell

Histone deacetylase 1 regulates the malignancy of oral cancer cells via miR-154-5p/PCNA axis

2020 ◽  
Vol 401 (11) ◽  
pp. 1273-1281
Author(s):  
Yuanjing Lv ◽  
Jinle Lu ◽  
Xin Liu ◽  
Susheng Miao ◽  
Xionghui Mao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Histone Deacetylases ◽  
Specific Inhibitor ◽  
Nuclear Antigen ◽  
Over Expression ◽  
Histone Deacetylase 1 ◽  
Oral Cancer Cells ◽  
Targeted Inhibition

AbstractHistone deacetylases (HDACs) can regulate the progression of various cancers, while their roles in oral cancer cells are not well known. Our present study found that the HDAC1 was over expressed in oral squamous cell carcinoma (OSCC) cells and tissues. Targeted inhibition of HDAC1 via its specific inhibitor PCI24781 or siRNA can inhibit the proliferation of OSCC cells and increase their sensitivity to the chemo-sensitivity such as doxorubicin treatment. HDAC1 can regulate the expression of proliferating cell nuclear antigen (PCNA) via decreasing its mRNA stability. While over expression of PCNA can attenuate HDAC1 inhibition induced suppression of cell proliferation. We checked the expression of various miRNAs which can target the 3′UTR of PCNA. Results showed that HDAC1 can negative regulate the expression of miR-154-5p, inhibitor of miR-154-5p can attenuate PCI24781 treatment decreased PCNA expression and cell proliferation. Collectively, our present study suggested that HDAC1 can promote the growth and progression of OSCC via regulation of miR-154-5p/PCNA signals.

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