Rapid and accurate amperometric determination of acetaminophen in pharmaceutical preparations and spiked human blood serum samples at cadmium pentacyanonitrosylferrate modified glassy carbon electrode

2008 ◽  
Vol 5 (2) ◽  
pp. 296-305 ◽  
Author(s):  
H. Razmi ◽  
M. Harasi
Keyword(s):  
Blood Serum ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Human Blood ◽  
Pharmaceutical Preparations ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Serum Samples ◽  
Amperometric Determination

scholarly journals Non-Enzymatic Amperometric Determination of Glucose by CuO Nanobelt Graphene Composite Modified Glassy Carbon Electrode

2015 ◽  
Author(s):  
Sreeramareddygari Muralikrishna ◽  
Kempahanumakkagari Sureshkumar ◽  
Zhou Yan ◽  
Carlos Fernandez ◽  
Thippeswamy Ramakrishnappa
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Amperometric Determination ◽  
Graphene Composite

scholarly journals Stripping Voltammetric Determination of Analgesics in Their Pharmaceuticals Using Nano-Riboflavin-Modified Glassy Carbon Electrode

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Gopalakrishnan Gopu ◽  
Paramasivam Manisankar ◽  
Baladhandapani Muralidharan ◽  
Chinnapiyan Vedhi
Keyword(s):  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Limit Of Detection ◽  
Pharmaceutical Preparations ◽  
Sem Analysis ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Diffusion Controlled ◽  
Influence Of Ph

Cyclic voltammetric behaviors of three analgesics, acetaminophen (AAP), acetylsalicylic acid (ASA), and dipyrone (DP), were studied using nano-riboflavin-modified glassy carbon electrode. One well-defined oxidation peak each for AAP and ASA and three oxidation peaks for DP were observed. The influence of pH, scan rate, and concentration reveals irreversible diffusion controlled reaction. The SEM analysis confirmed good accumulation of the drugs on the electrode surface. Calibration was made under the maximum peak current conditions. The concentration range studied for the determination of drugs was 0.02 to 0.4 μg mL−1for AAP and ASA and 0.025 to 0.4 μg mL−1for DP. The lower limit of detection observed for AAP, ASA, and DP was 0.016, 0.007 μg mL−1, and 0.013 μg mL−1, respectively. The suitability of the method for the determination of these analgesics in pharmaceutical preparations and urine samples was also ascertained.

scholarly journals Amperometric Determination of Nitrite at Poly(Methylene Blue)-Modified Glassy Carbon Electrode

2012 ◽  
Vol 33 (2) ◽  
pp. 415-419 ◽  
Author(s):  
Guang-Ri Xu ◽  
Guifang Xu ◽  
Ming-Lu Xu ◽  
Zhengqing Zhang ◽  
Yuan Tian ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Amperometric Determination

Electroanalytical analysis of guaifenesin on poly(acridine orange) modified glassy carbon electrode and its determination in pharmaceuticals and serum samples

2020 ◽  
Vol 23 ◽  
Author(s):  
Hasan Işik ◽  
Gökçe Öztürk ◽  
Fatma Ağin ◽  
Dilek Kul
Keyword(s):  
Human Serum ◽  
Acridine Orange ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Supporting Electrolyte ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Serum Samples ◽  
Human Serum Samples

Background: Electroanalytical methods are very functional to detect drugs in pharmaceuticals (tablets, syrups, suppositories, creams and ointments) and biological samples. Objective: In this study, it is aimed to make selective, sensitive, simple, fast and low cost electrochemical analysis of expectorant drug guaifenesin in pharmaceuticals and serum samples. Method: Differential pulse adsorptive stripping voltammetric method for determination of guaifenesin on a poly(acridine orange) modified glassy carbon electrode has been developed. Glassy carbon electrode was modified with electropolymerization of acridine orange monomer for sensitive determination of guaifenesin. Guaifenesin provided highly reproducible and well-defined irreversible oxidation peaks at +1.125 V and +1.128 V (vs. Ag/AgCl) in the selected supporting electrolyte and human serum samples, respectively. Results: Under optimized conditions, linear response of peak current on the concentration of guaifenesin has been obtained in the ranges of 2.00×10-7 to 1.00×10-4 M in Britton Robinson buffer solution at pH 7.0 and 4.00×10-7 to 1.00×10-4 M in serum samples. The precision of the method was detected by intraday and inter-day repeatability studies in the supporting electrolyte and serum samples media. Conclusion: The analytical applicability of the proposed method exhibited satisfying determination results for guaifenesin from pharmaceutical dosage forms (syrup) and human serum samples without any pre-separation procedure.

Electrooxidation Behavior and Amperometric Determination of Sotalol on a Graphene Oxide Nanosheets-modified Glassy Carbon Electrode

2013 ◽  
Vol 9 (3) ◽  
pp. 291-298 ◽  
Author(s):  
Hossein Heli ◽  
Seyede Nasrin Zare ◽  
Naghmeh Sattarahmady ◽  
Khashayar Karimian
Keyword(s):  
Graphene Oxide ◽  
Glassy Carbon Electrode ◽  
Glassy Carbon ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Graphene Oxide Nanosheets ◽  
Amperometric Determination

scholarly journals Poly(4-amino-3-hydroxynaphthalene-1-sulfonic acid) modified glassy carbon electrode for square wave voltammetric determination of amoxicillin in four tablet brands

BMC Chemistry ◽  
2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Adane Kassa ◽  
Meareg Amare
Keyword(s):  
Glassy Carbon Electrode ◽  
Modified Electrode ◽  
Glassy Carbon ◽  
Sulfonic Acid ◽  
Current Response ◽  
Carbon Electrode ◽  
Modified Glassy Carbon Electrode ◽  
Serum Samples ◽  
Square Wave

Abstract Background Amoxicillin (AMX), which is one of the β-lactam antibiotics used in the treatment of bacterial infections, is known to have a serious mechanism of resistance necessitating continuous monitoring of its level in pharmaceutical and serum samples. Results In this study, we presented selective, accurate, and precise square wave voltammetric method based on poly(4-amino-3-hydroxynaphthalene-1-sulfonic acid) modified glassy carbon electrode (poly(AHNSA/GCE)) for determination of amoxicillin in four selected tablet brands. Appearance of a peak in the oxidative scan direction without a peak in the reductive direction of cyclic voltammograms of both bare GCE and poly(AHNSA/GCE) with four folds current and much reduced potential on the modified electrode showed catalytic property of the modifier towards oxidation of AMX. While cyclic voltammetric studies of effect of scan rate showed predominantly diffusion controlled oxidation of AMX with one electron participation, effect of pH revealed participation of protons and electrons in a 1:1 ratio. The square wave voltammetric peak current response of the modified electrode for AMX showed linear dependence on the concentration of the spiked standard AMX in the range 10–150 µmol L−1 with 9.9 nmol L−1 LOD. The AMX content of the studied tablet brands were found in the range 97.84–100.78% of the labeled value. Spike recovery results of 99.6–100.5%, and interference recovery results of 95.4–100.8% AMX in the presence of 50–200% of ampicillin and cloxicillin validated the applicability of the method for determination of amoxicillin in tablet formulation. Conclusion In contrast to the previously reported works on determination of amoxicillin, the present method showed an excellent performance making it a potential method for determination of amoxicillin in real samples including serum samples.

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