scholarly journals A Population-based Hepatitis B Seroprevalence and Risk Factor Study in a Northern Ontario Town

1997 ◽  
Vol 88 (2) ◽  
pp. 87-90 ◽  
Author(s):  
Kevin W. Glasgow ◽  
Richard Schabas ◽  
David C. Williams ◽  
Evelyn Wallace ◽  
Lee Ann Nalezyty
2010 ◽  
Vol 13 (8) ◽  
pp. 1215-1220 ◽  
Author(s):  
Anu Ruusunen ◽  
Soili M Lehto ◽  
Tommi Tolmunen ◽  
Jaakko Mursu ◽  
George A Kaplan ◽  
...  

AbstractObjectiveOnly a few cross-sectional studies have assessed the association between coffee, tea and caffeine and the risk of depression. Our aim was to determine the association in a population-based cohort study.DesignThe population-based Kuopio Ischaemic Heart Disease Risk Factor Study cohort was recruited between 1984 and 1989 and followed until the end of 2006. We investigated the association between the intake of coffee, tea and caffeine and depression.SettingEastern Finland.SubjectsMiddle-aged men (n 2232).ResultsAltogether, forty-nine men received a discharge diagnosis of depression. We classified subjects into quartiles according to their mean daily coffee intake: non-drinkers (n 82), light drinkers (<375 ml/d, n 517), moderate drinkers (375–813 ml/d, n 1243) and heavy drinkers (>813 ml/d, n 390). Heavy drinkers had a decreased risk (RR = 0·28, 95 % CI 0·08, 0·98) for depression when compared with non-drinkers, after adjustment for age and examination years. Further adjustment for socio-economic status, alcohol consumption, smoking, maximal oxygen uptake, BMI and the energy-adjusted daily intakes of folate and PUFA did not attenuate this association (relative risk (RR) = 0·23, 95 % CI 0·06, 0·83). No associations were observed between depression and intake of tea (drinkers v. non-drinkers; RR = 1·19, 95 % CI 0·54, 2·23) or caffeine (highest quartile v. lowest quartile; RR = 0·99, 95 % CI 0·40, 2·45).ConclusionsCoffee consumption may decrease the risk of depression, whereas no association was found for tea and caffeine intake.


1989 ◽  
Vol 21 (3) ◽  
pp. 227-229 ◽  
Author(s):  
Jukka T. Salonen ◽  
Kari Seppänen ◽  
Rainer Rauramaa ◽  
Riitta Salonen

Author(s):  
J. Skov Neergaard ◽  
K. Dragsbæk ◽  
C. Christiansen ◽  
M. Asser Karsdal ◽  
S. Brix ◽  
...  

Background: Identification of subjects with a progressive disease phenotype is an urgent need in the pharmaceutical industry where most of the recent clinical trials in Alzheimer’s disease have failed. Objectives: The objective of this study was to identify subgroups of individuals with objective cognitive impairment (OCI), who were most likely to progress to dementia and to identify the risk factors associated with progression. Design: Prospective cohort study. Setting: Population-based. Participants: 5,380 elderly women from Denmark. Measurements: The Short Blessed Test and a category fluency test with animal naming, was used to assess cognitive function, and to classify them into different groups of OCI. Results: OCI was identified in 852 subjects at baseline. The risk of dementia was elevated for OCI subjects as compared to subjects with normal cognition (HR 1.46[1.19-1.79]). The courses of OCI were studied in a sub-cohort who completed the cognitive assessment at both the baseline and the follow-up visit (n = 1,933). Of these subjects 203 had OCI at baseline. The multi-domain subtypes of OCI were associated with progressive OCI. Subjects most likely to progress were older, physically inactive, had a higher level of total cholesterol (>6.5 mmol/L) and had a history of depression as compared to subjects with a non-progressive course of OCI. Conclusions: In this cohort we identified a risk profile associated with progression from OCI in older women. The degree of impairment at baseline was an important predictor of conversion to dementia, additionally several modifiable risk factors were associated with progression.


2013 ◽  
pp. 1143-1144
Author(s):  
David J. Finitsis ◽  
Peter Kaufmann ◽  
Akihito Shimazu ◽  
Jussi Kauhanen

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