A Simultaneous Discovery: The Case of Johannes Stark and Antonino Lo Surdo

2004 ◽  
Vol 6 (3) ◽  
pp. 271-294 ◽  
Author(s):  
Matteo Leone ◽  
Alessandro Paoletti ◽  
Nadia Robotti
Keyword(s):  
Johannes Stark ◽  
Simultaneous Discovery

scholarly journals 50th anniversary of the discovery of reverse transcriptase

2021 ◽  
Vol 32 (2) ◽  
pp. 91-97
Author(s):  
John M. Coffin
Keyword(s):  
Cancer Research ◽  
Reverse Transcriptase ◽  
Paradigm Shift ◽  
Rous Sarcoma Virus ◽  
50Th Anniversary ◽  
Theoretical Base ◽  
Simple Experiment ◽  
Rous Sarcoma ◽  
Sarcoma Virus ◽  
Simultaneous Discovery

The simultaneous discovery in 1970 of reverse transcriptase in virions of retroviruses by Howard Temin and David Baltimore was perhaps the most dramatic scientific moment of the second half of the 20th century. Ten years previously, Temin’s observation of cells transformed by Rous Sarcoma virus led him to the conclusion that retroviruses replicate through a DNA intermediate he called the provirus. This heretical hypothesis was greeted with derision by fellow scientists; Temin and Baltimore performed a simple experiment, rapidly reproduced, and convincing to all. Its result was a major paradigm shift—reversal of the central dogma of molecular biology. It immediately grabbed the attention of both the scientific and lay press. It also came at a key time for cancer research, at the start of the “War on Cancer.” As a theoretical base and fundamental molecular tool, it enabled a decade of (largely fruitless) search for human oncogenic retroviruses but laid the foundation for the discovery of HIV 13 years later, leading to the development of effective therapy. I had the good fortune, as a student in Temin’s lab, to witness these events. I am honored to be able to share my recollection on the occasion of their 50th anniversary.

scholarly journals A new way to build cell lineages

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Xiuwei Zhang ◽  
Nir Yosef
Keyword(s):  
Single Cell ◽  
Computational Analysis ◽  
Cell Lineages ◽  
Simultaneous Discovery

A combination of single-cell techniques and computational analysis enables the simultaneous discovery of cell states, lineage relationships and the genes that control developmental decisions.

Erinnerungen eines deutschen Naturforschers. Johannes Stark , Andreas Kleinert

Isis ◽  
1988 ◽  
Vol 79 (3) ◽  
pp. 550-551
Author(s):  
Bruce R. Wheaton
Keyword(s):  
Johannes Stark

scholarly journals Simultaneous discovery of bifrontal meningiomas and a glioblastoma multiforme

2014 ◽  
Vol 2014 (apr17 1) ◽  
pp. bcr2013203296-bcr2013203296
Author(s):  
J. Woodley-Cook ◽  
A. Bharatha ◽  
J. Spears
Keyword(s):  
Glioblastoma Multiforme ◽  
Simultaneous Discovery

Secrecy, simultaneous discovery, and the theory of nuclear reactors

1977 ◽  
Vol 45 (11) ◽  
pp. 1049-1060 ◽  
Author(s):  
Spencer Weart
Keyword(s):  
Nuclear Reactors ◽  
Simultaneous Discovery
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