In vitro cytotoxicity, antimicrobial, and metal-chelating activity of triterpene saponins from tea seed grown in Kangra valley, India

2012 ◽  
Vol 22 (8) ◽  
pp. 4030-4038 ◽  
Author(s):  
Robin Joshi ◽  
Swati Sood ◽  
Poonam Dogra ◽  
Madhvi Mahendru ◽  
Dharmesh Kumar ◽  
...  
Keyword(s):  
In Vitro Cytotoxicity ◽  
Triterpene Saponins ◽  
Chelating Activity ◽  
Metal Chelating ◽  
Metal Chelating Activity

Synthesis, Characterization, Antimicrobial and Antioxidant Activities of 1,2,4-triazolyl-isoxazole Moieties via Dehydration Reactions of Carbohydrazides

2021 ◽  
Vol 18 ◽  
Author(s):  
Asma K. Alshamari ◽  
Mahmoud A. Al-Qudah ◽  
Fedaa Hamadeh ◽  
Lo’ay A. Al-Momani ◽  
Sultan T. Abu-Orabi
Keyword(s):  
Free Radical ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Pharmaceutical Chemistry ◽  
Chelating Activity ◽  
Metal Chelating ◽  
Metal Chelating Activity ◽  
Dehydration Reactions ◽  
New Compounds

: For the reason of distinct place in the field of medicinal and pharmaceutical chemistry of 1,2,4-triazole derivatives, a new class of fused 1,2,4-triazolyl-isoxazole moieties was prepared from 3-(2,4,6-trimethoxyphenyl)isoxazolo-4,5-bis[carbonyl-(4̍-phenyl) thiosemicarbazide via dehydration reactions of carbohydrazides by using the appropriate chemical reagents. The structures of the compounds were elucidated by both elemental and spectral (IR, NMR and MS) analyses. The in vitro antioxidant activity of the new compounds was determined by free radical scavenging and metal chelating activity. All the synthesized compounds showed good activity according to free radical scavenging and metal chelating activity compared with standards. The new compounds were screened in vitro antibacterial activity against three gram-positive bacteria and three gram-negative bacteria.

Functional and Antioxidant Properties of Angelwing Clam (Phplas orientalis) Hydrolysate Produced using Alcalase

2014 ◽  
Vol 11 (1) ◽  
pp. 29
Author(s):  
Nonnah Ismail ◽  
Juliana Mahmod ◽  
Awatif Khairul Fatihin Mustafa Kamal
Keyword(s):  
Antioxidant Properties ◽  
Enzyme Concentration ◽  
Degree Of Hydrolysis ◽  
Emulsifying Properties ◽  
Hydrolysis Time ◽  
Chelating Activity ◽  
Metal Chelating ◽  
Metal Chelating Activity ◽  
Intermediate Concentration ◽  
As Solubility

In this study, Hydrolysate from angelwing clam (Pholas orientalis) was produced at 0, 1, 2 and 3 hrs and E/S ratio of0.5 and 3%using alcalase where the pH and temperature were kept constant at pH 8.5 and 60°C, respectively. The hydrolysates were analysed for antioxidant and functional properties such as solubility, emulsifying properties and water and oil holding capacity. Degree of hydrolysis (DH), yield, functional and antioxidant properties were influenced by the hydrolysis time and E/S ratio. Higher enzyme concentration (E/S 3%) and longer hydrolysis time increased the DH. Yield was higher at E/S 3% but reduced with hydrolysis time. Longer hydrolysis time produced more soluble hydrolysate and higher metal chelating activity but lower in emulsifying properties and DPPH activity. Higher enzyme concentration resulted in increase only in solubility and metal chelating activity. This study revealed that enzymatic hydrolysis using alcalase should be performed at shorter hydrolysis time using intermediate concentration of enzyme (E/S between 0.5 to 3%) in order to produce angelwing clam hydrolysate with collectively good functional and antioxidant properties. 

scholarly journals Effect of packaging on phenols, flavonoids and antioxidant characteristics of mechanical cabinet dried wild pomegranate (Punica granatum L.) arils

2021 ◽  
Vol 13 (1) ◽  
pp. 101-109
Author(s):  
Abhimanyu Thakur ◽  
NS Thakur ◽  
Hamid ◽  
Sunakshi Gautam
Keyword(s):  
Antioxidant Activity ◽  
Reducing Power ◽  
Punica Granatum ◽  
Total Phenols ◽  
Antioxidant Power ◽  
Chelating Activity ◽  
Metal Chelating ◽  
Temperature Conditions ◽  
Metal Chelating Activity ◽  
Punica Granatum L

Wild pomegranate (Punica granatum L.) fruit arils with high acid content are processed into dried arils (anardana) which is used as an ingredient in various medicinal formulations and culinary preparations. The various phenols and flavonoids are responsible for the antioxidant activity of anardana which signifies its functional benefits. The advanced packaging techniques like vacuum packaging, can retain higher antioxidant activity characteristics during storage. So, the present studies were carried out to compare the effect of packaging on total phenols, flavonoids, DPPH (2, 2-diphenyl-1-picrylhydrazyl) antioxidant activity, metal chelating activity, FRAP (ferric reducing antioxidant power) and reducing power of anardana prepared in mechanical cabinet drier. Anardana was packed in different packaging materials and stored under ambient and refrigerated temperature conditions. The overall effect of storage during 12 months revealed that there was a significant (p< 0.05) decrease in total phenols (180.95 to 161.76 mg GAE/100 g), flavonoids (40.60 to 32.66 mg QuE/100 g), DPPH antioxidant activity (61.23 to 56.13%), metal chelating activity (22.25 to 19.37%), FRAP (34.60 to 31.73 ?M Fe2+/100 g) and reducing power (0.610 to 0.521) which was observed less in anardana packed in ALPV (aluminium laminated pouches with vacuum) followed by ALP (aluminium laminated pouches) and gunny bags. Due to slower rates of degradation of various antioxidant compounds, the changes after 12 months of storage were lower under refrigerated conditions. The total phenols, flavonoids and DPPH antioxidant activity were reduced  from 180.95 to 167.24 and 156.28 mg GAE/100 g, 40.60 to 34.95 and 30.37 mg QuE/100 g and 61.23 to 57.99 and 54.27 % in refrigerated and ambient temperature conditions, respectively.

Functional and Antioxidant Properties of Angelwing Clam (Pholas orientalis) Hydrolysate Produced using Alcalase

2014 ◽  
Vol 11 (1) ◽  
pp. 29
Author(s):  
Normah Ismail ◽  
Juliana Mahmod ◽  
Awatif Khairul Fatihin Mustafa Kamal
Keyword(s):  
Antioxidant Properties ◽  
Enzyme Concentration ◽  
Degree Of Hydrolysis ◽  
Emulsifying Properties ◽  
Hydrolysis Time ◽  
Chelating Activity ◽  
Metal Chelating ◽  
Metal Chelating Activity ◽  
Intermediate Concentration ◽  
As Solubility

In this study, hydrolysate from angelwing clam (Pholas orientalis) was produced at 0, 1, 2 and 3 hrs and E/S ratio of 0.5 and 3% using alcalase where the pH and temperature were kept constant at pH 8.5 and 60°C, respectively. The hydrolysates were analysed for antioxidant and functional properties such as solubility, emulsifying properties and water and oil holding capacity. Degree of hydrolysis (DH), yield, functional and antioxidant properties were influenced by the hydrolysis time and E/S ratio. Higher enzyme concentration (E/S 3%) and longer hydrolysis time increased the DH. Yield was higher at E/S 3% but reduced with hydrolysis time. Longer hydrolysis time produced more soluble hydrolysate and higher metal chelating activity but lower in emulsifying properties and DPPH activity. Higher enzyme concentration resulted in increase only in solubility and metal chelating activity. This study revealed that enzymatic hydrolysis using alcalase should be performed at shorter hydrolysis time using intermediate concentration of enzyme (E/S between 0.5 to 3%) in order to produce angelwing clam hydrolysate with collectively good functional and antioxidant properties.

scholarly journals Antiparkinson drug - Mucuna pruriens shows antioxidant and metal chelating activity

2007 ◽  
Vol 22 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Muralikrishnan Dhanasekaran ◽  
Binu Tharakan ◽  
Bala V. Manyam
Keyword(s):  
Mucuna Pruriens ◽  
Antiparkinson Drug ◽  
Chelating Activity ◽  
Metal Chelating ◽  
Metal Chelating Activity

scholarly journals The synthesis of some β-lactams and investigation of their metal-chelating activity, carbonic anhydrase and acetylcholinesterase inhibition profiles

2016 ◽  
Vol 31 (sup1) ◽  
pp. 79-88 ◽  
Author(s):  
Burhanettin Turan ◽  
Kivilcim Şendil ◽  
Emin Şengül ◽  
Mehmet Serdar Gültekin ◽  
Parham Taslimi ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Acetylcholinesterase Inhibition ◽  
Chelating Activity ◽  
Metal Chelating ◽  
Metal Chelating Activity
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