Design and synthesis of potential fungicidal compounds derived from natural products, (-)-menthol and (-)-borneol

Design and synthesis of a hybrid framework of indanone and chromane: total synthesis of a homoisoflavanoid, brazilane

Organic & Biomolecular Chemistry ◽

10.1039/c7ob02758c ◽

2018 ◽

Vol 16 (1) ◽

pp. 89-100 ◽

Cited By ~ 5

Author(s):

Jinwoo Kim ◽

Ikyon Kim

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Hybrid Structure ◽

Design And Synthesis ◽

Hybrid Framework

A chemical backbone of tetracyclic homoisoflavanoid natural products such as brazilin inspired us to design a new chemical scaffold, 6a,11b-dihydroindeno[2,1-c]chromen-7(6H)-one, which is a hybrid structure of indanone and chromane.

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From Protein Domains to Drug Candidates — Natural Products as Guiding Principles in Compound Library Design and Synthesis

Small Molecule — Protein Interactions ◽

10.1007/978-3-662-05314-0_11 ◽

2003 ◽

pp. 167-188

Author(s):

R. Breinbauer ◽

I. R. Vetter ◽

H. Waldmann

Keyword(s):

Natural Products ◽

Protein Domains ◽

Library Design ◽

Compound Library ◽

Drug Candidates ◽

Design And Synthesis ◽

Guiding Principles

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From Protein Domains to Drug CandidatesâNatural Products as Guiding Principles in the Design and Synthesis of Compound Libraries

Angewandte Chemie International Edition ◽

10.1002/1521-3773(20020816)41:16<2878::aid-anie2878>3.0.co;2-b ◽

2002 ◽

Vol 41 (16) ◽

pp. 2878 ◽

Cited By ~ 282

Author(s):

Rolf Breinbauer ◽

Ingrid R. Vetter ◽

Herbert Waldmann

Keyword(s):

Natural Products ◽

Protein Domains ◽

Design And Synthesis ◽

Compound Libraries ◽

Guiding Principles

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Structure-based synthesis: From natural products to drug prototypes

Pure and Applied Chemistry ◽

10.1351/pac-con-08-07-12 ◽

2009 ◽

Vol 81 (6) ◽

pp. 1085-1091 ◽

Cited By ~ 4

Author(s):

Stephen Hanessian

Keyword(s):

Natural Products ◽

Total Synthesis ◽

Design Element ◽

X Ray ◽

Design And Synthesis ◽

Highly Active ◽

In Vitro Inhibition ◽

Inhibitory Activities ◽

Active Natural

X-ray crystallographic data available from complexes of natural and synthetic molecules with the enzyme thrombin has led to the design and synthesis of truncated and hydrid molecules exhibiting excellent inhibition in vitro. The design element has also been extended to the synthesis and in vitro inhibition of a series of achiral molecules deploying aromatic and heterocyclic core motifs with appropriately functionalized appendages that provide excellent binding interactions at the S1, S2, and S3 sites of thrombin. Excellent selectivity for thrombin over trypsin has also been observed. Thus, studies in total synthesis of highly active natural aeruginosins have inspired further work toward truncated and hybrid analogs with excellent inhibitory activities. Structure-based organic synthesis has guided our research from natural products toward unnatural drug-like prototypes.

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