A Novel Imaging Grading Biomarker for Predicting Hearing Loss in Acoustic Neuromas

Author(s):  
Wenjianlong Zhou ◽  
Yangyang Wang ◽  
Shunchang Ma ◽  
Linhao Yuan ◽  
Xi Wang ◽  
...  
1978 ◽  
Vol 43 (4) ◽  
pp. 459-466 ◽  
Author(s):  
Shlomo Silman ◽  
Stanley A. Gelfand ◽  
Tong Chun

The subject was a 47-year-old male with a moderate asymmetrical sensorineural hearing loss that initially presented cochlear signs except for positive stapedius reflex results. Over the course of only five weeks, he developed the audiological constellation of retrocochlear involvement. The retrocochlear results were confirmed by the removal of an acoustic tumor. The results highlight the importance of audiological monitoring and reflex measures in the identification of acoustic neuromas. Several observations provide insight into the apparent relationship between loudness and the stapedius reflex. The findings are discussed with reference to a proposed extension of Borg’s recent theory that elevated reflex thresholds and reflex decay reflect differing degrees of the eighth nerve destruction.


2019 ◽  
Vol 80 (S 03) ◽  
pp. S267-S268
Author(s):  
James K. Liu ◽  
Vincent N. Dodson ◽  
Robert W. Jyung

The translabyrinthine approach is advantageous for the resection of large acoustic neuromas compressing the brainstem when hearing loss is nonserviceable. This approach provides wide access through the presigmoid corridor without prolonged cerebellar retraction. Early identification of the facial nerve at the fundus is also achieved. In this operative video atlas manuscript, the authors demonstrate a step-by-step technique for microsurgical resection of a large cystic acoustic neuroma via a translabyrinthine approach. The nuances of microsurgical and skull base technique are illustrated including performing extracapsular dissection of the tumor while maintaining a subperineural plane of dissection to preserve the facial nerve. This strategy maximizes the extent of removal while preserving facial nerve function. A microscopic remnant of tumor was left adherent to the perineurium. A near-total resection of the tumor was achieved and the facial nerve stimulated briskly at low thresholds. Other than preexisting hearing loss, the patient was neurologically intact with normal facial nerve function postoperatively. In summary, the translabyrinthine approach and the use of subperineural dissection are important strategies in the armamentarium for surgical management of large acoustic neuromas while preserving facial nerve function.The link to the video can be found at: https://youtu.be/zld2cSP8fb8.


1972 ◽  
Vol 37 (4) ◽  
pp. 548-552
Author(s):  
Beth Urban ◽  
Thelma Hilger Generous

A case is presented of a 17-year-old female with bilateral acoustic neuromas not associated with multiple neurofibromatosis. The progressive nature of the hearing loss, retrocochlear audiometric test results as well as physical symptoms suggested bilateral acoustic neuromas. Both neuromas were removed with resulting total hearing loss.


1991 ◽  
Vol 111 (sup487) ◽  
pp. 138-143 ◽  
Author(s):  
Kaoru Ogawa ◽  
Jin Kanzaki ◽  
Shigeo Ogawa ◽  
Nobuaki Tsuchihashi ◽  
Yasuhiro Inoue

2001 ◽  
Vol 95 (5) ◽  
pp. 771-777 ◽  
Author(s):  
Christian Strauss ◽  
Barbara Bischoff ◽  
Mandana Neu ◽  
Michael Berg ◽  
Rudolf Fahlbusch ◽  
...  

Object. Delayed hearing loss following surgery for acoustic neuroma indicates anatomical and functional preservation of the cochlear nerve and implies that a pathophysiological mechanism is initiated during surgery and continues thereafter. Intraoperative brainstem auditory evoked potentials (BAEPs) typically demonstrate gradual reversible loss of components in these patients. Methods. Based on this BAEP pattern, a consecutive series of 41 patients with unilateral acoustic neuromas was recruited into a prospective randomized study to investigate hearing outcomes following the natural postoperative course and recuperation after vasoactive medication. Both groups were comparable in patient age, tumor size, and preoperative hearing level. Twenty patients did not receive postoperative medical treatment. In 70% of these patients anacusis was documented and in 30% hearing was preserved. Twenty-one patients were treated with hydroxyethyl starch and nimodipine for an average of 9 days. In 66.6% of these patients hearing was preserved and in 33.3% anacusis occurred. Conclusions. These results are statistically significant (p < 0.05, χ2 = 5.51) and provide evidence that these surgically treated patients suffer from a disturbed microcirculation that causes delayed hearing loss following removal of acoustic neuromas.


1988 ◽  
Vol 98 (2) ◽  
pp. 138-143 ◽  
Author(s):  
Herbert Silverstein ◽  
Horace Norrell ◽  
Eric Smouha ◽  
Thomas Haberkamp

The singular canal transmits the posterior ampullary nerve between the inferior part of the internal auditory canal (IAC) and ampulla of the posterior semicircular canal. The anatomy of the singular canal was studied in temporal bone dissections, in surgical dissections, and in high-resolution computerized tomography scans. Measurements were taken for distances between the origin of the singular canal in the IAC, the porus acousticus, the vestibule, and posterior canal ampulla. The location and importance of the singular canal are demonstrated for retrosigmoid-IAC vestibular neurectomy, retrosigmoid acoustic neuroma surgery, and transcochlear cochleovestibular neurectomy. The main purpose for the use of the retrosigmoid approach to the internal auditory canal during vestibular neurectomy and excision of acoustic neuromas is preservation of hearing. A major concern when the contents of the internal auditory canal are exposed through this approach is fenestration of the labyrinth, which results in sensorineural hearing loss. In the retrosigmoid approach, the singular canal has been found to be a vital landmark in prevention of fenestration during surgery of the internal auditory canal.


1989 ◽  
Vol 103 (9) ◽  
pp. 845-849 ◽  
Author(s):  
M. Tos ◽  
N. Trojaborg ◽  
J. Thomsen

AbstractTo determine whether translabyrinthine acoustic surgery may result in a drill-generated, bone-conducted sensorineural hearing impairment in the contralateral ear, the audiograms from 50 consecutive patients with acoustic neuromas undergoing the translabyrinthine approach were compared before and three months after surgery. No case of sensorineural hearing impairment could be demonstrated post-operatively.


Author(s):  
Dimitrios Kikidis ◽  
Ioannis Xenellis ◽  
Efthymios Kyrodimos ◽  
Aristeidis Sismanis

<p class="abstract"><strong><span lang="EN-US">Background:</span></strong>Since the use of magnetic resonance imaging (MRI) as the gold standard for acoustic neuroma diagnosis, the size of the majority of newly diagnosed acoustic neuromas has decreased. Management strategy is challenging, especially in young patients with small tumors. Therefore, prognostic factors for tumor growth may facilitate physicians to optimize treatment choice.</p><p class="abstract"><strong><span lang="EN-US">Methods:</span></strong>Patients diagnosed with acoustic neuromas were recruited in this study. Gender, age, side, presence of hearing loss, tinnitus, vertigo, unsteadiness, other symptoms, hearing level in the affected ear and tumor growth at the first follow up MRI were recorded. Two primary endpoints were set: overall acoustic neuroma (AN) growth and growth correlated to treatment plan change (clinically significant growth). Multivariate and survival analysis were conducted to this end.  </p><p class="abstract"><strong><span lang="EN-US">Results:</span></strong>85 patients were finally included in the study. The most prevalent presenting symptoms were hearing loss (76%), tinnitus (56%) and unsteadiness (46%). The tumour grew in size in less than 50% of the cases during the observation period. Clinically significant growth was observed in 27% of the cases. Mean initial diameter was 10.41mm and mean final follow-up diameter (diameter at the end of the observation period) 12.73 mm. Following binary logistic regression analysis, tumour growth during the initial follow up visit was found to be correlated in a statistically significant level to overall tumour growth (p-value 0.023). Regarding clinically significant growth, three factors were found to be statistically significant: growth at the initial visit (p-value 0.02), initial diameter (p-value 0.045) and existence of unsteadiness at diagnosis (p-value 0.02).</p><p class="abstract"><strong><span lang="EN-US">Conclusions:</span></strong>Acoustic neuroma overall growth is not identical to clinically significant growth. Growth at first visit is a significant prognostic factor and intervention potential should be considered under this perspective.</p>


1995 ◽  
Vol 112 (5) ◽  
pp. P25-P26
Author(s):  
Noel L. Cohen ◽  
Roy A. Holiday

Educational objectives: To better evaluate the patient with unilateral sensorineural hearing loss and to develop a diagnostic algorithm for the diagnosis of acoustic neuromas.


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