Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure

2019 ◽  
Vol 97 (4) ◽  
pp. 451-462 ◽  
Author(s):  
You Wu ◽  
Yong-Ming Yao ◽  
Zhong-Qiu Lu
Keyword(s):  
Quality Control ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Therapeutic Targets ◽  
Multiple Organ ◽  
Control Mechanisms ◽  
Mitochondrial Quality Control

scholarly journals Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Cheng-long Zhu ◽  
Ren-qi Yao ◽  
Lu-xi Li ◽  
Peng Li ◽  
Jian Xie ◽  
...  
Keyword(s):  
Quality Control ◽  
Organ Failure ◽  
Organ Dysfunction ◽  
Therapeutic Target ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Potential Therapeutic Target ◽  
Mitochondrial Quality Control ◽  
Evolutionarily Conserved ◽  
Pathophysiological Role

Autophagy, an evolutionarily conserved process, plays an important role in maintaining cellular homeostasis under physiological and pathophysiological conditions. It is widely believed that mitochondria influence the development of disease by regulating cellular metabolism. When challenged by different stimuli, mitochondria may experience morphological disorders and functional abnormalities, leading to a selective form of autophagy—mitophagy, which can clear damaged mitochondria to promote mitochondrial quality control. Sepsis is a complex global problem with multiple organ dysfunction, often accompanied by manifold mitochondrial damage. Recent studies have shown that autophagy can regulate both innate and acquired immune processes to protect against organ dysfunction in sepsis. Sepsis-induced mitochondrial dysfunction may play a pathophysiological role in the initiation and progression of sepsis-induced organ failure. Mitophagy is reported to be beneficial for sepsis by eliminating disabled mitochondria and maintaining homeostasis to protect against organ failure. In this review, we summarize the recent findings and mechanisms of mitophagy and its involvement in septic organ dysfunction as a potential therapeutic target.

Clinical case of periostitis in pregnant women complicated by sepsis

2020 ◽  
pp. 61-63
Author(s):  
S. Sh. Kakvaeva ◽  
M. A. Magomedova ◽  
A. N. Dzhalilova
Keyword(s):  
Pregnant Woman ◽  
Multiple Organ Failure ◽  
Pregnant Women ◽  
Organ Failure ◽  
Clinical Case ◽  
Clinical Observation ◽  
Infectious Agent ◽  
Modern Medicine ◽  
Multiple Organ ◽  
Number Of Patients

One of the most serious problems of modern medicine is sepsis. The number of patients undergoing this complication is 20–30 million (WHO) annually and has no tendency to decrease. Sepsis is characterized by severe multiple organ failure due to a violation of the response of the macroorganism to an infectious agent. Moreover, it is dangerous with high mortality. Sepsis often develops in patients with immunodeficiency conditions, which primarily include pregnant women. The article presents a clinical observation of a case of periostitis in a pregnant woman complicated by a septic state.

Failures of intensive treatment of multiple organ failure: pathophysiology and the need for personalization

2019 ◽  
pp. 48-57
Author(s):  
E.V. Grigoryev ◽  
◽  
D.L. Shukevich ◽  
G.P. Plotnikov ◽  
A.N. Kudryavtsev ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Intensive Treatment

scholarly journals High-dose diquat poisoning: a case report

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110261
Author(s):  
Yanxia Huang ◽  
Renjing Zhang ◽  
Mei Meng ◽  
Dechang Chen ◽  
Yunxin Deng
Keyword(s):  
Renal Failure ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
High Dose ◽  
Severe Respiratory Failure ◽  
Aggressive Treatment ◽  
Lung Lesions ◽  
Pulmonary Lesions ◽  
New Treatment

Diquat is a widely used herbicide that is substituted for paraquat. With paraquat off the market, cases of diquat poisoning have been gradually increasing. The kidney is the most frequently impaired organ in diquat poisoning. Few cases of multiple organ failure caused by diquat have been reported. We herein describe a 30-year-old man who orally ingested about 160 mL of enriched diquat. Despite aggressive treatment, the patient’s condition progressed to multiple organ failure and death. The pulmonary lesions in this patient were different from those previously reported. This patient did not die of renal failure but of severe respiratory failure. He exhibited three different stages of pulmonary disease. The lung lesions in this case were unique. We hope that doctors will pay more attention to the lung lesions in patients with diquat poisoning in future and find new treatment methods to save the lives of such patients.

Endovascular treatment of an ilio-iliac arteriovenous fistula accompanied by venous thromboembolism presenting with multiple organ failure – A case report and literature review

Vascular ◽  
2021 ◽  
pp. 170853812199657
Author(s):  
Tiehao Wang ◽  
Jichun Zhao ◽  
Ding Yuan
Keyword(s):  
Multiple Organ Failure ◽  
Arteriovenous Fistula ◽  
Organ Failure ◽  
Iliac Artery ◽  
Vena Cava ◽  
Artery Aneurysm ◽  
Multiple Organ ◽  
High Rate ◽  
Type Ii ◽  
Type Ii Endoleak

Objectives Multiple organ failure is a rare manifestation of ilio-iliac arteriovenous fistula which can lead to a high rate of misdiagnosis and death. Methods We reported a 61-year-old man presenting with multiple organ failure rapidly after right lower limb swelling. Computed tomography angiography showed an ilio-iliac arteriovenous fistula caused by right common iliac artery aneurysm, and venous thrombosis of bilateral common iliac veins. A bifurcated stent-graft with coil embolization of right internal iliac artery was used for repair. Results The patient recovered rapidly and was discharged without complications. Although arteriovenous fistula persisted due to type II endoleak, aneurysm sac and inferior vena cava significantly shrunk at six months follow-up. Conclusions This report demonstrated that multiple organ failure may appear when the distal outflow tracts of arteriovenous fistula are obstructed. Moreover, endovascular repair is effective for reversal of multiple organ failure caused by arteriovenous fistula, even if arteriovenous fistula persists due to type II endoleak.

scholarly journals Post-COVID-19 Kawasaki-Like Syndrome

2021 ◽  
pp. 014556132110060
Author(s):  
Jérôme R. Lechien ◽  
Rémi Hervochon ◽  
Stéphane Hans
Keyword(s):  
Abdominal Pain ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Hepatitis A ◽  
Clinical Presentation ◽  
Multiple Organ ◽  
Mild Form ◽  
Severe Dysphagia ◽  
History Of ◽  
Inflammatory Syndrome

A 42-year-old man was referred for a week history of severe dysphagia, odynophagia, fever (39 °C), fatigue, abdominal pain, pharyngeal swelling, and multiple neck lymphadenopathies. The medical history reported a mild form of COVID-19 one month ago. The biology reported an unspecified inflammatory syndrome. The patient developed peritonitis, myocarditis, and hepatitis. A myocardium biopsy was performed. A diagnosis of Kawasaki-like disease (KLD) was performed. The occurrence of KLD in adults is rare but has to be known by otolaryngologists regarding the otolaryngological clinical presentation that may precede the multiple organ failure.

Epidemiology of post-injury multiple organ failure in an Australian trauma system

2009 ◽  
Vol 79 (6) ◽  
pp. 431-436 ◽  
Author(s):  
David C. Dewar ◽  
Peter Mackay ◽  
Zsolt Balogh
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Trauma System ◽  
Multiple Organ ◽  
Post Injury
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