AMPK: a key regulator of energy stress and calcium-induced autophagy

Author(s):  
Rimpi Saikia ◽  
Jomon Joseph
Keyword(s):  
Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 36-OR
Author(s):  
LOUISE LANTIER ◽  
CURTIS C. HUGHEY ◽  
DAVID WASSERMAN

2015 ◽  
Vol 7 (3) ◽  
pp. 1959-1969 ◽  
Author(s):  
C. Y. Lo

The Biefeld-Brown (B-B) effect consists of two parts: 1) the initial thrust is due to the electric potential that moves the electrons to the positive post; and 2) the subsequent lift is due to the separate concentration of the positive and the negative charges. The weight reduction of a charged capacitor is due to a repulsive charge-mass interaction, which is normally cancelled by the attractive current-mass interaction. In a charged capacitor, some electrons initially moving in the orbits become statically concentrated and thus a net repulsive force is exhibited. Based on observations, it is concluded that a repulsive charge-mass interaction is proportional to the charge density square and diminishes faster than the attractive gravitational force, and that the current-mass force is perpendicular to the current. This charge-mass interaction is crucial to establish the unification of electromagnetism and gravitation. To confirm general relativity further, experimental verification of the details of this mass-charge repulsive force is recommended. Moreover, general relativity implies that the photons must include gravitational energy and this explains that experiments show that the photonic energy is equivalent to mass although the electromagnetic energy-stress tensor is traceless. In general relativity,it is crucial to understandnon-linear mathematics and that the Einstein equation has no bounded dynamic solutions. However, due to following Einstein's errors, theorists failed in understanding these and ignored experimental facts on repulsive gravitation. Since the charge-mass interaction occurs in many areas of physics, Einstein's unification is potentially another revolution in physics. Moreover, the existence of a repulsive gravitation implies the necessity of re-justifying anew the speculation of black holes.


2016 ◽  
Vol 18 (4) ◽  
pp. 431-442 ◽  
Author(s):  
Xiaowen Liu ◽  
Zhen-Dong Xiao ◽  
Leng Han ◽  
Jiexin Zhang ◽  
Szu-Wei Lee ◽  
...  
Keyword(s):  

Oncogene ◽  
2017 ◽  
Vol 36 (34) ◽  
pp. 4901-4912 ◽  
Author(s):  
J Li ◽  
Q Huang ◽  
X Long ◽  
X Guo ◽  
X Sun ◽  
...  

Cancers ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 375 ◽  
Author(s):  
Henry McCann ◽  
Charlotte Johnson ◽  
Rachel Errington ◽  
D. Davies ◽  
Elaine Dunlop ◽  
...  

To find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within Tuberous Sclerosis Complex 2 (TSC2)-deficient cells with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. We show that nelfinavir and mefloquine synergize to selectively evoke a cytotoxic response in TSC2-deficient cell lines with mTORC1 hyperactivity. We optimize the concentrations of nelfinavir and mefloquine to a clinically viable range that kill cells that lack TSC2, while wild-type cells tolerate treatment. This new clinically viable drug combination causes a significant level of cell death in TSC2-deficient tumor spheroids. Furthermore, no cell recovery was apparent after drug withdrawal, revealing potent cytotoxicity. Transcriptional profiling by RNA sequencing of drug treated TSC2-deficient cells compared to wild-type cells suggested the cytotoxic mechanism of action, involving initial ER stress and an imbalance in energy homeostatic pathways. Further characterization revealed that supplementation with methyl pyruvate alleviated energy stress and reduced the cytotoxic effect, implicating energy deprivation as the trigger of cell death. This work underpins a critical vulnerability with cancer cells with aberrant signaling through the TSC2-mTORC1 pathway that lack flexibility in homeostatic pathways, which could be exploited with combined nelfinavir and mefloquine treatment.


1976 ◽  
Vol 37 (1) ◽  
pp. 263-270 ◽  
Author(s):  
Y. Motohashi ◽  
P. Braillon ◽  
J. Serughetti

2019 ◽  
Vol 31 (6) ◽  
pp. 472-486 ◽  
Author(s):  
Lorna J. Daniels ◽  
Upasna Varma ◽  
Marco Annandale ◽  
Eleia Chan ◽  
Kimberley M. Mellor ◽  
...  

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