Whole-limb scaling of muscle mass and force-generating capacity in amniotes

Skeletal muscle mass, architecture and force-generating capacity are well known to scale with body size in animals, both throughout ontogeny and across species. Investigations of limb muscle scaling in terrestrial amniotes typically focus on individual muscles within select clades, but here this question was examined at the level of the whole limb across amniotes generally. In particular, the present study explored how muscle mass, force-generating capacity (measured by physiological cross-sectional area) and internal architecture (fascicle length) scales in the fore- and hindlimbs of extant mammals, non-avian saurians (‘reptiles’) and bipeds (birds and humans). Sixty species spanning almost five orders of magnitude in body mass were investigated, comprising previously published architectural data and new data obtained via dissections of the opossum Didelphis virginiana and the tegu lizard Salvator merianae. Phylogenetic generalized least squares was used to determine allometric scaling slopes (exponents) and intercepts, to assess whether patterns previously reported for individual muscles or functional groups were retained at the level of the whole limb, and to test whether mammals, reptiles and bipeds followed different allometric trajectories. In general, patterns of scaling observed in individual muscles were also observed in the whole limb. Reptiles generally have proportionately lower muscle mass and force-generating capacity compared to mammals, especially at larger body size, and bipeds exhibit strong to extreme positive allometry in the distal hindlimb. Remarkably, when muscle mass was accounted for in analyses of muscle force-generating capacity, reptiles, mammals and bipeds almost ubiquitously followed a single common scaling pattern, implying that differences in whole-limb force-generating capacity are principally driven by differences in muscle mass, not internal architecture. In addition to providing a novel perspective on skeletal muscle allometry in animals, the new dataset assembled was used to generate pan-amniote statistical relationships that can be used to predict muscle mass or force-generating capacity in extinct amniotes, helping to inform future reconstructions of musculoskeletal function in the fossil record.

Photon Force MEMS cantilever combined with fibre optic system as a measurement technique for optomechanical studies

In this paper we present a metrological measurement technique that is a combination of fibre optic interferometry and a microelectromechanical system (MEMS) sensor for photon force (PF) measurement with traceability via an electromagnetic way. The main advantage of the presented method is the reference to the current balance, which is the primary mass/force metrological standard. The MEMS cantilever is a transducer of the photon force to the deflection that can be compensated with the use of the Lorentz force. This movement is measured with the use of the interferometer and does not require any mechanical calibration. Combining the MEMS current balance system with the interferometry is then the unique and fully metrological solution. The resolution of the proposed measurement technique is calculated to be 4 pN//Hz^(0.5) (2% uncertainty). The PF–MEMS used for the investigation is the cantilever with the resolution of 46 fN/Hz0.5, which was calculated from the thermomechanical noise, and is far below the whole system resolution limit. As far as the whole construction is based on the fibre optic system, it does not require any complex adjustment procedure and may work as an optomechanical reference in any metrological laboratory.

Resonant Motions of Dynamic Offshore Structures in Large Waves

In marine engineering, the dynamics of fixed offshore structures (for oil and gas production or for wind turbines) are normally found by modelling of the motion by a classical mass-spring damped system. On slender offshore structures, the loading due to waves is normally calculated by applying a force which consists of two parts: a linear “inertia/mass force” and a non-linear “drag force” that is proportional to the square of the velocity of the particles in the wave, multiplied by the direction of the wave particle motion. This is the so-called Morison load model. The loading function can be expanded in a Fourier series, and the drag force contribution exhibits higher order harmonic loading terms, potentially in resonance with the natural frequencies of the system. Currents are implemented as constant velocity terms in the loading function. The paper highlights the motion of structures due to non-linear resonant motion in an offshore environment with high wave intensity. It is shown that “burst”/“ringing” type motions could be triggered by the drag force during resonance situations.

Added-mass force on elliptic airfoils

Herein, exact algebraic expressions for the non-circulatory (added-mass) forces on elliptic airfoils are derived for any two-dimensional motion – including simultaneous rectilinear acceleration and rotation – embedded in a steady free-stream flow. Despite the lengthy history of the added-mass concept and its widespread application to cylinders of various cross-sections, such closed-form expressions for elliptic cylinders, in terms of kinematic and geometric parameters alone, have remained absent from the literature until now. Inspection of the derived equations reveals that for pure pitching about a point on the chord-line, increasing thickness always decreases the added-mass force magnitude. For any given motion of the chord-line, the difference in force between thick and thin airfoils is proportional to the square of the thickness, although this difference may be positive or negative for the general three-degree-of-freedom case. In the special case of zero thickness and small pitch angles, Theodorsen's added-mass lift force on rigid thin airfoils is recovered; for large pitch angles, an exact generalization of Theodorsen's expression, applicable to the chord-normal direction, is given.

Dense Suspension Flows: a Mathematical Model Consistent with Thermodynamics

We address the flows of dense suspensions of particles within the framework of two-velocity continuum. Thermodynamics of such a continuum is developed by the method suggested in the papers of L. D. Landau and I. M. Khalatnikov. As an application, we consider the convective settling problem. We capture the Boycott effect and prove that the enhanced sedimentation occurs in a 10 tilted vessel due to vortices. We do not call on additional interphase forces like the Stokes drag, the virtual mass force, the Archimedes force, the Basset-Boussinesq force and etc. Instead, we apply a generalized Fick's law for the particle mass concentration flux vector.

Deletion of muscle Igf1 exacerbates disuse atrophy weakness in mice

Muscle atrophy occurs as a result of prolonged periods of reduced mechanical stimulation associated with injury or disease. The growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and load sensing pathways can both aid in recovery from disuse through their shared downstream signaling, but their relative contributions to these processes are not fully understood. The goal of this study was to determine if reduced muscle IGF-1 altered the response to disuse and reloading. Adult male mice with inducible muscle-specific IGF-1 deletion (MID) induced 1 week before suspension and age-matched controls (CON) were subjected to hindlimb suspension and reloading. Analysis of muscle force, morphology, gene expression, signaling, and tissue weights were performed in non-suspended mice, and those suspended for 7 days, or reloaded following suspension for 3-, 7-, and 14 days. MID mice displayed diminished IGF-1 protein levels and muscle atrophy prior to suspension. Muscles from suspended CON mice displayed a similar extent of atrophy and depletion of IGF-1, yet combined loss of load and IGF-1 was not additive with respect to muscle mass. In contrast, soleus force generation capacity was diminished to the greatest extent when both suspension and IGF-1 deletion occurred. Recovery of mass, force, and gene expression patterns following suspension were similar in CON and MID mice, even though IGF-1 levels increased only in muscles from CON mice. Diminished strength in disuse atrophy is exacerbated with the loss of muscle IGF-1 production, whereas recovery of mass and strength upon reloading can occur even IGF-1 is low.

CFD–DEM Simulation of Sand-Retention Mechanisms in Slurry Flow

The primary motivation of this paper is to investigate the sand-retention mechanisms that occur at the opening of sand filters. Various retention mechanisms under various conditions are explored that have a particulate flow with a low concentration of sand particles (called slurry flow) such as particle shape, size, and concentration. The computational fluid dynamic (CFD)–discrete element method (DEM) model is applied to predict the retention mechanisms under steady flow conditions of the well-bore. By using coupled CFD–DEM (CFD to model the fluid flow, and DEM to model the particle flow), the physics involved in the retention mechanisms is studied. The coarse grid unresolved and the smoothed unresolved (refined grid unresolved) coupling approaches implemented in STAR-CCM+ (SIEMENS PLM) are used to transfer data between the fluid and solid phases and calculate the forces. The filter slots under investigation have different geometries: straight, keystone, wire-wrapped screen (WWS) and seamed slot and the particles are considered with different shapes and different aspect ratios and size distributions. The flow regime is laminar in all simulations conducted. The CFD–DEM model is validated from the perspectives of particle–fluid, particle–particle, and particle–wall interactions. Verification of the CFD–DEM model is conducted by mesh sensitivity analysis to investigate the coupling resolution between the CFD and DEM. By simulation of numerous slurry flow scenarios, three retention mechanisms including surface deposition, size exclusion, and sequential arching of particles are observed. However, the concentration of particles is too diluted to result in multiparticle arch formation. In the simulations, various conditions are tested to give us an insight into the parameters and conditions that could affect the occurrence of the retention mechanisms. As an example, the importance of the gravity force and interaction forces on retention mechanisms are confirmed at the microscale in comparison with others forces involved in retention mechanisms such as the drag force, lift force, cohesive force, buoyancy force, and virtual mass force.