current mass
Recently Published Documents


TOTAL DOCUMENTS

122
(FIVE YEARS 41)

H-INDEX

18
(FIVE YEARS 3)

2022 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sandip Mukhopadhyay ◽  
Ritesh Pandey ◽  
Bikramjit Rishi

PurposeIn recent times, the growing use of electronic word of mouth (eWOM) has attracted consumers, organizations and marketers alike. The objective of this study is to summarize and compare the current mass of eWOM research published in leading hospitality and tourism journals with research published in the other fields of both business and management.Design/methodology/approachThis study uses multiple bibliometric analysis methods, including citation, co-citation, keyword and co-word analysis. It compares various assessments of eWOM research published in 399 selected business publications and 398 selected hospitality/tourism publications (ABDC A and above and ABS 3 and above) between 2003 and 2021.FindingsThe co-citation analysis identified three thematic areas under each of the domains, i.e. in the hospitality/tourism field, the three themes included eWOM and behavior; eWOM and social media; and eWOM as a marketing tool. Similarly, under the business field (encompasses remaining business and management subdisciplines), the three themes are eWOM and sales, eWOM quality and attributes; and eWOM, information and consumer. Additionally, the word and co-word analysis mapped the comparative evolution of research in these two fields. The study advocates more research focusing on less researched platforms using diverse data, recommender systems adoption and application of eWOM in the business to business (B2B) context.Research limitations/implicationsThis study summarizes the overall theoretical and conceptual structure of eWOM research in both business and hospitality/tourism fields; based upon which, several recommendations for future research are proposed.Originality/valueBy comparing the developments in the specialized hospitality/tourism sector with broader management literature using multiple, complementary techniques, this study brings out important insights for hospitality/tourism researchers.


By quantizing space-time in such a way that I can calculate all of the constants of physics and derive and explain every equation therein. The magnetic field appears when the electric field seems to travel faster than c. The same way an “anti-gravity” perpendicular field appears, totally depended on relative velocities, since the electric and gravitational forces are made of the micro field lines and are different aspects of the same force [1]. The “gravitational” perpendicular force can be repellant, when masses travel in the same direction, (massive distant galaxies repel enlarging the universe, new current mass just being released) and it can be attractive (opposite spiral arms moving in opposite directions, combined with a super-massive black hole). The recent detection of gravity waves, is clear evidence for all of this since these waves need a perpendicular field, like electro-magnetic waves. The magnetic style of the perpendicular field, at extremely high can cause matter and dark to interact


Foods ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2932
Author(s):  
Martin Röder ◽  
Claudia Wiacek ◽  
Frauke Lankamp ◽  
Jonathan Kreyer ◽  
Wolfgang Weber ◽  
...  

Food allergies are caused by severe hypersensitivity to specific food allergens such as the egg protein ovalbumin. It is therefore important to test food products for the presence of allergens to protect allergic people from accidental ingestion. For egg detection, ELISA is the only reasonable commercially available test format, although the recognition of target allergens can be affected by food processing, which may lead to false negative results. Current mass spectrometry-based detection methods may overcome this issue, but these approaches are often less sensitive. Here we combined the advantages of antibody-based and MS-based methods by developing an immunoaffinity LC-MS/MS technique to detect the common egg allergen Gal d 2. We investigated the principal functionality of this method with incurred cookie material containing whole egg powder. We found that the new method matched easily the sensitivity of egg specific ELISA tests. Further western blot experiments indicated that this strategy may be unaffected by food processing, providing an important alternative strategy for the detection and quantification of allergens in food.


2021 ◽  
Author(s):  
Antoine AbdelMassih ◽  
Meryam El Shershaby ◽  
Hanya Gaber ◽  
Habiba-Allah Ismail ◽  
Nadine El-Hussseiny ◽  
...  

Abstract Background: With the current mass international roll out of several vaccines against SARS-Cov-2, several reports of unheeded complications have made headlines. One of which involves myocarditis with the now FDA fully approved vaccine, Pfizer, and others. We hypothesize through this study that a dysregulated micro-RNA response resulting from such type of vaccines can be involved in triggering myocarditis. Methodology: Embase, Medline and the Cochrane Central Register were used to search for specific keywords such as “mRNA COVID-19 vaccines” AND “Myocarditis” for relevant publications up to 1st of September 2021. The systematic review was performed using PRISMA protocolResults:Literature review has identified 26 cases series and reports involving the development of myocarditis from mRNA vaccines, a total of 89 patients were included. Age range was clearly identified in 66 patients. Among those 66 patients, 94% were below 50 years of age, also out of 89 patients, 94% were males. Myocarditis developed, after a median time of 72 hours of the 2nd dose. 90 of cases of myocarditis developed myocarditis after the 2nd dose, the few patients developing myocarditis after the first dose were either predisposed by a history of myocarditis or a history of previous COVID-19 infection. Conclusion:In conclusion, interpretation of the results in view of the suggested hypothesis, reveals that the micro-RNAs implicated in myocarditis in general are as well implicated in the pathogenesis of severe COVID-19, this can explain why patients having a first dose with a history of COVID-19 can develop myocarditis from mRNA vaccines, also the relatively higher likelihood of this complication in males and younger aged individuals can be explained by the upregulation of key myocarditis related miRNAs in those two strata, due to higher muscle mass and suggests performing a sarcopenia index in recipients of the vaccine to correlate it with the likelihood of this complication. This could later set a cut-off of this easy bed-side index to stratify cases a higher risk of this rare complication.


2021 ◽  
Author(s):  
Jason Derks ◽  
Andrew Leduc ◽  
R. Gray Huffman ◽  
Harrison Specht ◽  
Markus Ralser ◽  
...  

Current mass-spectrometry methods enable high-throughput proteomics of large sample amounts, but proteomics of low sample amounts remains limited in depth and throughput. We aimed to increase the throughput of high-sensitivity proteomics while achieving high proteome coverage and quantitative accuracy. We developed a general experimental and computational framework, plexDIA, for simultaneously multiplexing the analysis of both peptides and samples. Multiplexed analysis with plexDIA increases throughput multiplicatively with the number of labels without reducing proteome coverage or quantitative accuracy. Specifically, plexDIA using 3-plex nonisobaric mass tags enables quantifying 3-fold more protein ratios among nanogram-level samples. Using 1 hour active gradients and first-generation Q Exactive, plexDIA quantified about 8,000 proteins in each sample of labeled 3-plex sets. Furthermore, plexDIA increases the consistency of protein quantification, resulting in over 2-fold reduction of missing data across samples. We applied plexDIA to quantify proteome dynamics during the cell division cycle in cells isolated based on their DNA content. The high sensitivity and accuracy of plexDIA detected many classical cell cycle proteins and discovered new ones. These results establish a general framework for increasing the throughput of highly sensitive and quantitative protein analysis.


2021 ◽  
Author(s):  
Antoine AbdelMassih ◽  
Meryam El Shershaby ◽  
Hanya Gaber ◽  
Habiba-Allah Ismail ◽  
Nadine El-Hussseiny ◽  
...  

Abstract Background: With the current mass international roll out of several vaccines against SARS-Cov-2, several reports of unheeded complications have made headlines. One of which involves myocarditis with the now FDA fully approved vaccine, Pfizer, and others. We hypothesize through this study that a dysregulated micro-RNA response resulting from such type of vaccines can be involved in triggering myocarditis. Methodology: Embase, Medline and the Cochrane Central Register were used to search for specific keywords such as “mRNA COVID-19 vaccines” AND “Myocarditis” for relevant publications up to 1st of September 2021. The systematic review was performed using PRISMA protocolResults:Literature review has identified 26 cases series and reports involving the development of myocarditis from mRNA vaccines, a total of 89 patients were included. Age range was clearly identified in 66 patients. Among those 66 patients, 94% were below 50 years of age, also out of 89 patients, 94% were males. Myocarditis developed, after a median time of 72 hours of the 2nd dose. 90 of cases of myocarditis developed myocarditis after the 2nd dose, the few patients developing myocarditis after the first dose were either predisposed by a history of myocarditis or a history of previous COVID-19 infection. Conclusion:In conclusion, interpretation of the results in view of the suggested hypothesis, reveals that the micro-RNAs implicated in myocarditis in general are as well implicated in the pathogenesis of severe COVID-19, this can explain why patients having a first dose with a history of COVID-19 can develop myocarditis from mRNA vaccines, also the relatively higher likelihood of this complication in males and younger aged individuals can be explained by the upregulation of key myocarditis related miRNAs in those two strata, due to higher muscle mass and suggests performing a sarcopenia index in recipients of the vaccine to correlate it with the likelihood of this complication. This could later set a cut-off of this easy bed-side index to stratify cases a higher risk of this rare complication.


Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 501
Author(s):  
Tarek Mohamed Abd El-Aziz ◽  
Yucheng Xiao ◽  
Jake Kline ◽  
Harold Gridley ◽  
Alyse Heaston ◽  
...  

The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, highlighting the potential to serve as a drug target. However, the biophysical mechanisms that regulate Nav1.8 activation and inactivation gating are not completely understood. Progress has been hindered by a lack of biochemical tools for examining Nav1.8 gating mechanisms. Arizona bark scorpion (Centruroides sculpturatus) venom proteins inhibit Nav1.8 and block pain in grasshopper mice (Onychomys torridus). These proteins provide tools for examining Nav1.8 structure–activity relationships. To identify proteins that inhibit Nav1.8 activity, venom samples were fractioned using liquid chromatography (reversed-phase and ion exchange). A recombinant Nav1.8 clone expressed in ND7/23 cells was used to identify subfractions that inhibited Nav1.8 Na+ current. Mass-spectrometry-based bottom-up proteomic analyses identified unique peptides from inhibitory subfractions. A search of the peptides against the AZ bark scorpion venom gland transcriptome revealed four novel proteins between 40 and 60% conserved with venom proteins from scorpions in four genera (Centruroides, Parabuthus, Androctonus, and Tityus). Ranging from 63 to 82 amino acids, each primary structure includes eight cysteines and a “CXCE” motif, where X = an aromatic residue (tryptophan, tyrosine, or phenylalanine). Electrophysiology data demonstrated that the inhibitory effects of bioactive subfractions can be removed by hyperpolarizing the channels, suggesting that proteins may function as gating modifiers as opposed to pore blockers.


2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Thomas Kiran Marella ◽  
Raya Bhattacharjya ◽  
Archana Tiwari

AbstractDiatoms are unicellular photosynthetic protists which constitute one of the most successful microalgae contributing enormously to global primary productivity and nutrient cycles in marine and freshwater habitats. Though they possess the ability to biosynthesize high value compounds like eicosatetraenoic acid (EPA), fucoxanthin (Fx) and chrysolaminarin (Chrl) the major bottle neck in commercialization is their inability to attain high density growth. However, their unique potential of acquiring diverse carbon sources via varied mechanisms enables them to adapt and grow under phototrophic, mixotrophic as well as heterotrophic modes. Growth on organic carbon substrates promotes higher biomass, lipid, and carbohydrate productivity, which further triggers the yield of various biomolecules. Since, the current mass culture practices primarily employ open pond and tubular photobioreactors for phototrophic growth, they become cost intensive and economically non-viable. Therefore, in this review we attempt to explore and compare the mechanisms involved in organic carbon acquisition in diatoms and its implications on mixotrophic and heterotrophic growth and biomolecule production and validate how these strategies could pave a way for future exploration and establishment of sustainable diatom biorefineries for novel biomolecules.


2021 ◽  
Vol 4 ◽  
Author(s):  
TaeOh Kwon ◽  
Hideaki Shibata ◽  
Sebastian Kepfer-Rojas ◽  
Inger K. Schmidt ◽  
Klaus S. Larsen ◽  
...  

Litter decomposition is a key process for carbon and nutrient cycling in terrestrial ecosystems and is mainly controlled by environmental conditions, substrate quantity and quality as well as microbial community abundance and composition. In particular, the effects of climate and atmospheric nitrogen (N) deposition on litter decomposition and its temporal dynamics are of significant importance, since their effects might change over the course of the decomposition process. Within the TeaComposition initiative, we incubated Green and Rooibos teas at 524 sites across nine biomes. We assessed how macroclimate and atmospheric inorganic N deposition under current and predicted scenarios (RCP 2.6, RCP 8.5) might affect litter mass loss measured after 3 and 12 months. Our study shows that the early to mid-term mass loss at the global scale was affected predominantly by litter quality (explaining 73% and 62% of the total variance after 3 and 12 months, respectively) followed by climate and N deposition. The effects of climate were not litter-specific and became increasingly significant as decomposition progressed, with MAP explaining 2% and MAT 4% of the variation after 12 months of incubation. The effect of N deposition was litter-specific, and significant only for 12-month decomposition of Rooibos tea at the global scale. However, in the temperate biome where atmospheric N deposition rates are relatively high, the 12-month mass loss of Green and Rooibos teas decreased significantly with increasing N deposition, explaining 9.5% and 1.1% of the variance, respectively. The expected changes in macroclimate and N deposition at the global scale by the end of this century are estimated to increase the 12-month mass loss of easily decomposable litter by 1.1–3.5% and of the more stable substrates by 3.8–10.6%, relative to current mass loss. In contrast, expected changes in atmospheric N deposition will decrease the mid-term mass loss of high-quality litter by 1.4–2.2% and that of low-quality litter by 0.9–1.5% in the temperate biome. Our results suggest that projected increases in N deposition may have the capacity to dampen the climate-driven increases in litter decomposition depending on the biome and decomposition stage of substrate.


2021 ◽  
Author(s):  
Tarek Mohamed Abd El-Aziz ◽  
Yucheng Xiao ◽  
Jake Kline ◽  
Harold Gridley ◽  
Alyse Heaston ◽  
...  

The voltage-gated sodium channel Nav1.8 is linked to neuropathic and inflammatory pain, high-lighting the potential to serve as a drug target. However, the biophysical mechanisms that regu-late Nav1.8 activation and inactivation gating are not completely understood. Progress has been hindered by a lack of biochemical tools for examining Nav1.8 gating mechanisms. Arizona bark scorpion (Centruroides sculpturatus) venom proteins inhibit Nav1.8 and block pain in grasshopper mice (Onychomys torridus). These proteins provide tools for examining Nav1.8 structure-activity relationships. To identify proteins that inhibit Nav1.8 activity, venom samples were fractioned using liquid chromatography (reversed phase and ion exchange). A recombinant Nav1.8 clone expressed in ND7/23 cells was used to identify subfractions that inhibited Nav1.8 Na+ current. Mass spectrometry-based bottom-up proteomic analyses identified unique peptides from inhibi-tory subfractions. A search of the peptides against the AZ bark scorpion venom gland transcrip-tome revealed four novel proteins between 40 and 60% conserved with venom proteins from scorpions in four genera (Centruroides, Parabuthus, Androctonus, and Tityus). Ranging from 63 to 82 amino acids, each primary structure includes 8 cysteines and a CXCE motif where X = an aro-matic residue (tryptophan, tyrosine or phenylalanine). Electrophysiology data demonstrated that the inhibitory effects of bioactive subfractions can be removed by hyperpolarizing the channels, suggesting that proteins may function as gating modifiers as opposed to pore blockers.


Sign in / Sign up

Export Citation Format

Share Document