Histone deacetylase 3 (HDAC3) as an important epigenetic regulator of kidney diseases

2021 ◽  
Author(s):  
Lijun Zhang ◽  
Wangsen Cao
Keyword(s):  
Histone Deacetylase ◽  
Kidney Diseases ◽  
Histone Deacetylase 3 ◽  
Epigenetic Regulator

scholarly journals The critical roles of histone deacetylase 3 in the pathogenesis of solid organ injury

2021 ◽  
Vol 12 (8) ◽  
Author(s):  
Li Ning ◽  
Xiong Rui ◽  
Wang Bo ◽  
Geng Qing
Keyword(s):  
Histone Deacetylase ◽  
Chromatin Remodeling ◽  
Current Knowledge ◽  
Organ Injury ◽  
Solid Organ ◽  
Solid Organ Injury ◽  
Histone Deacetylase 3 ◽  
Physiological Conditions ◽  
Inflammatory Conditions ◽  
Therapeutic Value

AbstractHistone deacetylase 3 (HDAC3) plays a crucial role in chromatin remodeling, which, in turn, regulates gene transcription. Hence, HDAC3 has been implicated in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. In addition, HDAC3 plays vital roles under physiological conditions by regulating circadian rhythms, metabolism, and development. In this review, we summarize the current knowledge of the physiological functions of HDAC3 and its role in organ injury. We also discuss the therapeutic value of HDAC3 in various diseases.

scholarly journals Histone deacetylase 3 as a novel therapeutic target in multiple myeloma

Leukemia ◽  
2013 ◽  
Vol 28 (3) ◽  
pp. 680-689 ◽  
Author(s):  
J Minami ◽  
R Suzuki ◽  
R Mazitschek ◽  
G Gorgun ◽  
B Ghosh ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Histone Deacetylase ◽  
Therapeutic Target ◽  
Histone Deacetylase 3 ◽  
Novel Therapeutic

scholarly journals miR-326-Histone Deacetylase-3 Feedback Loop Regulates the Invasion and Tumorigenic and Angiogenic Response to Anti-cancer Drugs

2014 ◽  
Vol 289 (40) ◽  
pp. 28019-28039 ◽  
Author(s):  
Youngmi Kim ◽  
Hyuna Kim ◽  
Hyunmi Park ◽  
Deokbum Park ◽  
Hansoo Lee ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Feedback Loop ◽  
Cancer Drugs ◽  
Histone Deacetylase 3 ◽  
Angiogenic Response ◽  
Anti Cancer

scholarly journals Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis

Autoimmunity ◽  
2009 ◽  
Vol 42 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Yutaka Kuwatsuka ◽  
Fumihide Ogawa ◽  
Yohei Iwata ◽  
Kazuhiro Komura ◽  
Eiji Muroi ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Histone Deacetylase ◽  
Histone Deacetylase 3

scholarly journals Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism–Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer

2016 ◽  
Vol 23 (12) ◽  
pp. 3139-3149 ◽  
Author(s):  
Azusa Tanimoto ◽  
Shinji Takeuchi ◽  
Sachiko Arai ◽  
Koji Fukuda ◽  
Tadaaki Yamada ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Histone Deacetylase ◽  
Deletion Polymorphism ◽  
Histone Deacetylase 3 ◽  
Egfr Mutant

scholarly journals Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs

2020 ◽  
Vol 56 (68) ◽  
pp. 9866-9869 ◽  
Author(s):  
Yufeng Xiao ◽  
Jia Wang ◽  
Lisa Y. Zhao ◽  
Xinyi Chen ◽  
Guangrong Zheng ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase 3

Potent and histone deacetylase 3 (HDAC3)-specific PROTAC XZ9002 is reported here.

scholarly journals Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation

2020 ◽  
Vol 80 (1) ◽  
pp. 43-58.e7
Author(s):  
Zhexu Chi ◽  
Sheng Chen ◽  
Ting Xu ◽  
Wenxuan Zhen ◽  
Weiwei Yu ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Histone Deacetylase ◽  
Fatty Acid Oxidation ◽  
Acid Oxidation ◽  
Histone Deacetylase 3
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