scholarly journals Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women

Diabetologia ◽  
2004 ◽  
Vol 48 (1) ◽  
pp. 8-16 ◽  
Author(s):  
K. A. McAuley ◽  
C. M. Hopkins ◽  
K. J. Smith ◽  
R. T. McLay ◽  
S. M. Williams ◽  
...  
Diabetologia ◽  
2005 ◽  
Vol 48 (5) ◽  
pp. 1033-1033
Author(s):  
K. A. McAuley ◽  
C. M. Hopkins ◽  
K. J. Smith ◽  
R. T. McLay ◽  
S. M. Williams ◽  
...  

1985 ◽  
Vol 54 (3) ◽  
pp. 567-575 ◽  
Author(s):  
H. C. Mehta ◽  
A. S. Saini ◽  
Harjit Singh ◽  
P. S. Dhatt

1. Sixty marasmic children were investigated for the absorption of xylose, proteins and fats. Their duodenal juice samples were also analysed for bile salts and microflora.2. The marasmic children were then studied in three groups of twenty by allocating them to three different dietary schedules: a high-protein diet (30% of the total energy from protein), a high-fat diet (40% of the total energy from fat) and a high-carbohydrate diet (70% of the total energy from carbohydrate) for 2 weeks and the previous measurements repeated.3. Whereas the high-fat diet resulted in improved fat absorption, along with an increase in total and conjugated bile acids, and the high-carbohydrate diet led to improved xylose absorption, the diet rich in protein resulted in an improvement in the absorption of all three dietary ingredients. It appears that a high-protein diet improves the overall absorption process by improving the intestinal environment as a whole, while high-carbohydrate and high-fat diets bring about adaptive changes related to the respective absorptive processes.


2019 ◽  
Author(s):  
Chrisabelle C. Mefferd ◽  
Shrikant S. Bhute ◽  
Jacqueline R. Phan ◽  
Jacob V. Villarama ◽  
Dung M. Do ◽  
...  

AbstractClostridioides difficile (formerly Clostridium difficile) infection (CDI) can result from the disruption of the resident gut microbiota. Western diets and popular weight-loss diets drive large changes in the gut microbiome; however, the literature is conflicted with regard to the effect of diet on CDI. Using the hypervirulent strain C. difficile R20291 (RT027) in a mouse model of antibiotic-induced CDI, we assessed disease outcome and microbial community dynamics in mice fed two high-fat diets in comparison with a high-carbohydrate diet and a standard rodent diet. The two high-fat diets exacerbated CDI, with a high-fat/high-protein, Atkins-like diet leading to severe CDI and 100% mortality, and a high-fat/low-protein, medium-chain triglyceride (MCT)-like diet inducing highly variable CDI outcomes. In contrast, mice fed a high-carbohydrate diet were protected from CDI, despite high refined carbohydrate and low fiber content. 28 members of the Lachnospiraceae and Ruminococcaceae decreased in abundance due to diet and/or antibiotic treatment; these organisms may compete with C. difficile for amino acids and protect healthy animals from CDI in the absence of antibiotics. Together, these data suggest that antibiotic treatment might lead to loss of C. difficile competitors and create a favorable environment for C. difficile proliferation and virulence that is intensified by high-fat/high-protein diets; in contrast, high-carbohydrate diets might be protective regardless of the source of carbohydrate.


1924 ◽  
Vol 40 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Theodore S. Moise ◽  
Arthur H. Smith

1. The toxicity of chloroform varies according to the diets used in these experiments in the following order of decreasing susceptibility of the animals: high fat > standard > high carbohydrate > high protein diets. 2. On the high fat and high carbohydrate diets there may be a more or less marked proliferation of the endothelium and the connective tissue stroma in the necrotic area producing in some instances scars resembling the picture of an early cirrhosis. 3. On the diets studied, standard, high carbohydrate, high protein, and high fat, the most active and rapid repair is observed on the standard balanced diet. On the high fat diet the reparative process is definitely delayed in comparison with the others. There are only slight differences between the high carbohydrate and high protein diets which suggest but do not conclusively show a more rapid repair with the latter diet.


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