scholarly journals The –174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institute’s Framingham Heart Study

Diabetologia ◽  
2005 ◽  
Vol 48 (8) ◽  
pp. 1492-1495 ◽  
Author(s):  
A. Herbert ◽  
C. Liu ◽  
S. Karamohamed ◽  
J. Schiller ◽  
J. Liu ◽  
...  
2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Camila Maciel de Oliveira ◽  
Jessica Pavani ◽  
José Eduardo Krieger ◽  
Rafael de Oliveira Alvim ◽  
Carlos Alberto Mourão-Junior ◽  
...  

2008 ◽  
Vol 25 (3) ◽  
pp. 268-276 ◽  
Author(s):  
B. I. Freedman ◽  
D. W. Bowden ◽  
S. S. Rich ◽  
J. Xu ◽  
L. E. Wagenknecht ◽  
...  

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29228 ◽  
Author(s):  
Anna Alkelai ◽  
Lior Greenbaum ◽  
Sara Lupoli ◽  
Yoav Kohn ◽  
Kyra Sarner-Kanyas ◽  
...  

2020 ◽  
Author(s):  
Juan Pan ◽  
Rui Tong ◽  
Qing Deng ◽  
Yanni Tian ◽  
Ning Wang ◽  
...  

Abstract Propose: We explored the effect of SOCS2 polymorphisms on the development of type 2 diabetes mellitus (T2DM) and diabetic complications.Methods: The subjects consisted of 500 T2DM patients and 501 healthy volunteers. Five variants in SOCS2 were genotyped by Agena MassARRAY system. Logistic regression analysis was utilized to calculate the odds ratio (OR) and 95% confidence intervals (95% CI).Results: Rs3825199 (OR = 1.44, p = 0.007), rs11107116 (OR = 1.39, p = 0.014) and rs10492321 (OR = 1.48, p = 0.004) had the increased T2DM risk. Moreover, the contribution of SOCS2 polymorphisms to T2DM risk was associated with age, gender, smoking and drinking and BMI. SOCS2 variants also had the reduced risk for T2DM patients with diabetic nephropathy, diabetic retinopathy and coronary heart disease.Conclusions: This study firstly reported that rs3825199, rs11107116 and rs10492321 in SOCS2 conferred to the increased risk for T2DM occurrence in the Chinese Han population.


Diabetologia ◽  
2018 ◽  
Vol 61 (12) ◽  
pp. 2570-2579 ◽  
Author(s):  
Ian J. Neeland ◽  
Shruti Singh ◽  
Darren K. McGuire ◽  
Gloria L. Vega ◽  
Thomas Roddy ◽  
...  

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