scholarly journals Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes

Diabetologia ◽  
2012 ◽  
Vol 55 (10) ◽  
pp. 2747-2758 ◽  
Author(s):  
N. Irwin ◽  
P. Frizelle ◽  
I. A. Montgomery ◽  
R. C. Moffett ◽  
F. P. M. O’Harte ◽  
...  
Keyword(s):  
Mouse Models ◽  
The Novel ◽  
Beneficial Effects

scholarly journals SPECT/CT Imaging of the Novel HER2-Targeted Peptide Probe99mTc-HYNIC-H6F in Breast Cancer Mouse Models

2017 ◽  
Vol 58 (5) ◽  
pp. 821-826 ◽  
Author(s):  
Liqiang Li ◽  
Yue Wu ◽  
Zihua Wang ◽  
Bing Jia ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mouse Models ◽  
Ct Imaging ◽  
The Novel

Lack of Antinociceptive Activity of Sumatriptan in Rodents

Cephalalgia ◽  
1990 ◽  
Vol 10 (5) ◽  
pp. 207-212 ◽  
Author(s):  
Malcolm Skingle ◽  
Phillip J Birch ◽  
Glynnis E Leighton ◽  
Patrick PA Humphrey
Keyword(s):  
Antinociceptive Activity ◽  
The Novel ◽  
Analgesic Action ◽  
Beneficial Effects ◽  
Noxious Stimuli ◽  
Anti Migraine Drug

The present study attempts to determine whether the novel anti-migraine drug sumatriptan has antinociceptive activity in rodents. Sumatriptan had little or no antinociceptive activity against a range of noxious stimuli and we therefore conclude that it is unlikely that the beneficial effects of the drug in treating migraine are due to a non-specific analgesic action.

scholarly journals Social Factors Influence Behavior in the Novel Object Recognition Task in a Mouse Model of Down Syndrome

2021 ◽  
Vol 15 ◽  
Author(s):  
Cesar Sierra ◽  
Ilario De Toma ◽  
Lorenzo Lo Cascio ◽  
Esteban Vegas ◽  
Mara Dierssen
Keyword(s):  
Down Syndrome ◽  
Object Recognition ◽  
Environmental Factors ◽  
Mouse Models ◽  
Recognition Task ◽  
Novel Object Recognition ◽  
The Novel ◽  
Wild Type ◽  
Male And Female ◽  
Novel Object

The use of mouse models has revolutionized the field of Down syndrome (DS), increasing our knowledge about neuropathology and helping to propose new therapies for cognitive impairment. However, concerns about the reproducibility of results in mice and their translatability to humans have become a major issue, and controlling for moderators of behavior is essential. Social and environmental factors, the experience of the researcher, and the sex and strain of the animals can all have effects on behavior, and their impact on DS mouse models has not been explored. Here we analyzed the influence of a number of social and environmental factors, usually not taken into consideration, on the behavior of male and female wild-type and trisomic mice (the Ts65Dn model) in one of the most used tests for proving drug effects on memory, the novel object recognition (NOR) test. Using principal component analysis and correlation matrices, we show that the ratio of trisomic mice in the cage, the experience of the experimenter, and the timing of the test have a differential impact on male and female and on wild-type and trisomic behavior. We conclude that although the NOR test is quite robust and less susceptible to environmental influences than expected, to obtain useful results, the phenotype expression must be contrasted against the influences of social and environmental factors.

Exosomes are the novel players involved in the beneficial effects of exercise on type 2 diabetes

2019 ◽  
Vol 234 (9) ◽  
pp. 14896-14905 ◽  
Author(s):  
Gaohua Li ◽  
Hua Liu ◽  
Chunlian Ma ◽  
Yanfang Chen ◽  
Jinju Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
The Novel ◽  
Beneficial Effects

Abstract LB-063: Anti-tumor activity of the novel dual p70S6KAKT inhibitor M2698 in glioma stem cell mouse models

2017 ◽  
Author(s):  
yuji piao ◽  
Craig Thomas ◽  
Verlene Henry ◽  
Ningyi Tiao ◽  
Soon Young park ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mouse Models ◽  
The Novel ◽  
Glioma Stem Cell ◽  
Anti Tumor Activity

2P-0529 A novel family of compounds with beneficial effects in mouse models of dyslipidemia and ischemic stroke

2003 ◽  
Vol 4 (2) ◽  
pp. 156
Author(s):  
L. Millatt ◽  
K. Bertrand ◽  
R. Darteil ◽  
P. Verwaerde ◽  
D.W. Hum ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Mouse Models ◽  
Beneficial Effects

scholarly journals Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis

2011 ◽  
Vol 17 (2) ◽  
pp. 532-542 ◽  
Author(s):  
Sundaram Ramasamy ◽  
Deanna D. Nguyen ◽  
Michelle A. Eston ◽  
Sayeda Nasrin Alam ◽  
Angela K. Moss ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Mouse Models ◽  
Chronic Colitis ◽  
Intestinal Alkaline Phosphatase ◽  
Beneficial Effects

scholarly journals Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8

2018 ◽  
Vol 315 (1) ◽  
pp. F57-F73
Author(s):  
Katy Billot ◽  
Charlène Coquil ◽  
Benoit Villiers ◽  
Béatrice Josselin-Foll ◽  
Nathalie Desban ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Mouse Models ◽  
Polycystic Kidney ◽  
Polycystic Kidneys ◽  
Cyclin Dependent Kinases ◽  
Drug Candidates ◽  
Beneficial Effects ◽  
Protein Levels ◽  
Casein Kinases

Following the discovery of (R)-roscovitine’s beneficial effects in three polycystic kidney disease (PKD) mouse models, cyclin-dependent kinases (CDKs) inhibitors have been investigated as potential treatments. We have used various affinity chromatography approaches to identify the molecular targets of roscovitine and its more potent analog (S)-CR8 in human and murine polycystic kidneys. These methods revealed casein kinases 1 (CK1) as additional targets of the two drugs. CK1ε expression at the mRNA and protein levels is enhanced in polycystic kidneys of 11 different PKD mouse models as well as in human polycystic kidneys. A shift in the pattern of CK1α isoforms is observed in all PKD mouse models. Furthermore, the catalytic activities of both CK1ε and CK1α are increased in mouse polycystic kidneys. Inhibition of CK1ε and CK1α may thus contribute to the long-lasting attenuating effects of roscovitine and (S)-CR8 on cyst development. CDKs and CK1s may constitute a dual therapeutic target to develop kinase inhibitory PKD drug candidates.

scholarly journals Role of nutrients regulation in the immune system in preventing COVID-19 infection: A brief review

2021 ◽  
Vol 13 (2) ◽  
pp. 760-765
Author(s):  
Anamika Chauhan
Keyword(s):  
Immune System ◽  
Age Groups ◽  
World Health ◽  
The Novel ◽  
Beneficial Effects ◽  
Coronavirus Infection ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

This review aimed to focus on using foods to boost immunity against COVID-19 in all age groups. In human, coronavirus causes the common cold, severe acute respiratory syndrome (SARS), and a major threat to public health. The novel coronavirus was declared a pandemic by the World Health Organization due to its rapid infectivity. COVID-19 infection is most probably reported in people with low immunity response. The nutrients, which show beneficial effects on the immune system, are called immune nutrients and diet is called immune diet. A healthy diet can reduce the risk of infection of COVID-19 and can prevent disease. Nutritional food intake is also necessary for people with chronic illness, obese persons, diabetes, cardiovascular disease, cognitive dysfunction like anxiety and depression. All nutrients are essential for maintaining immunity and providing appropriate amounts of protein, fat, carbohydrate, vitamins, and minerals for the surveillance mode of keeping us from getting sick. The use of plenty of water, minerals such as micronutrients, zinc, copper, selenium, iron, magnesium, food rich in vitamins, and a good lifestyle can promote health and overwhelm this coronavirus infection.

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