Lack of Antinociceptive Activity of Sumatriptan in Rodents

Cephalalgia ◽  
1990 ◽  
Vol 10 (5) ◽  
pp. 207-212 ◽  
Author(s):  
Malcolm Skingle ◽  
Phillip J Birch ◽  
Glynnis E Leighton ◽  
Patrick PA Humphrey
Keyword(s):  
Antinociceptive Activity ◽  
The Novel ◽  
Analgesic Action ◽  
Beneficial Effects ◽  
Noxious Stimuli ◽  
Anti Migraine Drug

The present study attempts to determine whether the novel anti-migraine drug sumatriptan has antinociceptive activity in rodents. Sumatriptan had little or no antinociceptive activity against a range of noxious stimuli and we therefore conclude that it is unlikely that the beneficial effects of the drug in treating migraine are due to a non-specific analgesic action.

Exosomes are the novel players involved in the beneficial effects of exercise on type 2 diabetes

2019 ◽  
Vol 234 (9) ◽  
pp. 14896-14905 ◽  
Author(s):  
Gaohua Li ◽  
Hua Liu ◽  
Chunlian Ma ◽  
Yanfang Chen ◽  
Jinju Wang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
The Novel ◽  
Beneficial Effects

scholarly journals Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes

Diabetologia ◽  
2012 ◽  
Vol 55 (10) ◽  
pp. 2747-2758 ◽  
Author(s):  
N. Irwin ◽  
P. Frizelle ◽  
I. A. Montgomery ◽  
R. C. Moffett ◽  
F. P. M. O’Harte ◽  
...  
Keyword(s):  
Mouse Models ◽  
The Novel ◽  
Beneficial Effects

scholarly journals Role of nutrients regulation in the immune system in preventing COVID-19 infection: A brief review

2021 ◽  
Vol 13 (2) ◽  
pp. 760-765
Author(s):  
Anamika Chauhan
Keyword(s):  
Immune System ◽  
Age Groups ◽  
World Health ◽  
The Novel ◽  
Beneficial Effects ◽  
Coronavirus Infection ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

This review aimed to focus on using foods to boost immunity against COVID-19 in all age groups. In human, coronavirus causes the common cold, severe acute respiratory syndrome (SARS), and a major threat to public health. The novel coronavirus was declared a pandemic by the World Health Organization due to its rapid infectivity. COVID-19 infection is most probably reported in people with low immunity response. The nutrients, which show beneficial effects on the immune system, are called immune nutrients and diet is called immune diet. A healthy diet can reduce the risk of infection of COVID-19 and can prevent disease. Nutritional food intake is also necessary for people with chronic illness, obese persons, diabetes, cardiovascular disease, cognitive dysfunction like anxiety and depression. All nutrients are essential for maintaining immunity and providing appropriate amounts of protein, fat, carbohydrate, vitamins, and minerals for the surveillance mode of keeping us from getting sick. The use of plenty of water, minerals such as micronutrients, zinc, copper, selenium, iron, magnesium, food rich in vitamins, and a good lifestyle can promote health and overwhelm this coronavirus infection.

scholarly journals 7-Isopentenyloxycoumarin: What Is New across the Last Decade

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 5923
Author(s):  
Francesca Preziuso ◽  
Salvatore Genovese ◽  
Lorenzo Marchetti ◽  
Majid Sharifi-Rad ◽  
Lucia Palumbo ◽  
...  
Keyword(s):  
Secondary Metabolite ◽  
Fruits And Vegetables ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
Future Research ◽  
The Novel ◽  
Human Welfare ◽  
Beneficial Effects ◽  
Long Time ◽  
Active Cancer

7-Isopentenyloxycoumarin is among the most widespread naturally occurring prenyloxy umbelliferone derivatives. This secondary metabolite of mixed biosynthetic origin has been typically isolated from plants belonging to several genera of the Rutaceae and Apiaceae families, comprising widely used medicinal plants and in general plants with beneficial effects on human welfare, as well as edible fruits and vegetables. Although known for quite a long time (more than 50 years), only in the last two decades has this natural compound been revealed to exert powerful and promising pharmacological properties, such as active cancer chemopreventive, antibacterial, antiprotozoal, antifungal, anti-inflammatory, neuroprotective, and antioxidant properties, among the activities best outlined in the recent literature. The aim of this comprehensive miniature review article is to detail the novel natural sources and the effects described during the last decade for 7-isopentenyloxycoumarin and what has been reported on the mechanisms of action underlying the observed biological activities of this oxyprenylated secondary metabolite. In view of the herein described data, suggestions on how to address future research on the abovementioned natural product and structurally related derivatives in the best ways according to the authors will be also provided.

scholarly journals Improving the Efficacy of Mesenchymal/Stromal-Based Therapy for Treatment of Inflammatory Bowel Diseases

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1507
Author(s):  
Mercedes Lopez-Santalla ◽  
Marina Inmaculada Garin
Keyword(s):  
Clinical Trials ◽  
Immune Responses ◽  
Inflammatory Bowel Diseases ◽  
Intestinal Inflammation ◽  
The Novel ◽  
Beneficial Effects ◽  
Commensal Microbiota ◽  
Bowel Diseases ◽  
Inflammatory Processes ◽  
Inflammatory Bowel

Inflammatory bowel diseases (IBD) consisting of persistent and relapsing inflammatory processes of the intestinal mucosa are caused by genetic, environmental, and commensal microbiota factors. Despite recent advances in clinical treatments aiming to decrease inflammation, nearly 30% of patients treated with biologicals experienced drawbacks including loss of response, while others can develop severe side effects. Hence, novel effective treatments are highly needed. Mesenchymal stem/stromal cell (MSCs) therapy is an innovative therapeutic alternative currently under investigation for IBD. MSCs have the inherent capacity of modulating inflammatory immune responses as well as regenerating damaged tissues and are therefore a prime candidate to use as cell therapy in patients with IBD. At present, MSC-based therapy has been shown preclinically to modulate intestinal inflammation, whilst the safety of MSC-based therapy has been demonstrated in clinical trials. However, the successful results in preclinical studies have not been replicated in clinical trials. In this review, we will summarize the protocols used in preclinical and clinical trials and the novel approaches currently under investigation which aim to increase the beneficial effects of MSC-based therapy for IBD.

scholarly journals Role of herbs for elevating immunity against SARS-CoV-2: a concise review

2021 ◽  
Vol 40 (2) ◽  
pp. 176-188
Author(s):  
Aashima Anand ◽  
Juhi Saraswat ◽  
Rajan Patel
Keyword(s):  
The Novel ◽  
Traditional Medicines ◽  
Beneficial Effects ◽  
Synthetic Drugs ◽  
Concise Review ◽  
Number Of Patients ◽  
Novel Coronavirus ◽  
Health Experts ◽  
Better Than

COVID-19 has emerged as a dreadful pandemic caused by the virus SARS-CoV-2. Though the number of patients recovering from infection is encouraging, sturdy cure is still being researched upon and the effective vaccines are yet to be rigidly resolute. COVID-19 has so far instigated a massive loss of lives globally and even the countries with the most advanced healthcare systems have come under its grasp. Health experts suggest in such case “Prevention is better than cure” which includes an appropriate daily lifestyle and a rugged immune system that could help mankind surmount this peril. This review highlights the importance of influential herbs and their medicinal significance. Biomedical articles were explored from PubMed, Google Scholar, Web of Science for the period of 2010-2021. Guidelines from the Ministry of Ayush (India) were also considered. The Ayurveda does not mention any cure for the novel coronavirus; however, it emphasizes the means of boosting one’s immunity. Accordingly, this article highlights some of the role of prevalent Ayurvedic herbs in promoting immunity for combating the novel coronavirus. The herbs in combination with drugs could be utilized for the sake of curtailing the side effects as well as the malefic repercussions of strong synthetic drugs used for treating COVID-19 patients, which would be a paramount leap in the field of Ayurveda as well as western-style medicine. However, the beneficial effects of these traditional medicines and their clinical trials remained to be known. We reviewed the latest updates on traditional medicines proposed for promoting immunity towards COVID-19.

scholarly journals Cannabinoids and Neurogenesis: The Promised Solution for Neurodegeneration?

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6313
Author(s):  
Andrea Valeri ◽  
Emanuela Mazzon
Keyword(s):  
Nervous System ◽  
Experimental Evidence ◽  
Neuronal Death ◽  
Synthetic Cannabinoids ◽  
Neuronal Population ◽  
Adult Brain ◽  
Analgesic Action ◽  
Beneficial Effects

The concept of neurons as irreplaceable cells does not hold true today. Experiments and evidence of neurogenesis, also, in the adult brain give hope that some compounds or drugs can enhance this process, helping to reverse the outcomes of diseases or traumas that once were thought to be everlasting. Cannabinoids, both from natural and artificial origins, already proved to have several beneficial effects (e.g., anti-inflammatory, anti-oxidants and analgesic action), but also capacity to increase neuronal population, by replacing the cells that were lost and/or regenerate a damaged nerve cell. Neurogenesis is a process which is not highly represented in literature as neuroprotection, though it is as important as prevention of nervous system damage, because it can represent a possible solution when neuronal death is already present, such as in neurodegenerative diseases. The aim of this review is to resume the experimental evidence of phyto- and synthetic cannabinoids effects on neurogenesis, both in vitro and in vivo, in order to elucidate if they possess also neurogenetic and neurorepairing properties.

scholarly journals SIT1 transporter as a potential novel target in treatment of COVID-19

2021 ◽  
Vol 12 (1) ◽  
pp. 156-163
Author(s):  
Sabina Semiz
Keyword(s):  
Chloride Channels ◽  
Partial Agonist ◽  
Severe Case ◽  
Protein Product ◽  
Diabetic Patients ◽  
The Novel ◽  
Efficient Treatment ◽  
Beneficial Effects ◽  
Novel Target

Abstract Studies published earlier this year demonstrated the association of the solute carrier SLC6A20 gene with the risk and severity of COVID-19. The SLC6A20 protein product (Sodium-dependent Imino Transporter 1 (SIT1)) is involved in the transport of amino acids, including glycine. Here we summarized the results of recent studies demonstrating the interaction of SIT1 with the ACE2 receptor for SARS-CoV-2 as well as an observed association of SLC6A20 with the risk and traits of Type 2 diabetes (T2D). Recently, it was also proposed that SLC6A20 represents the novel regulator of glycine levels and that glycine has beneficial effects against the proinflammatory cytokine secretion induced by SARS-CoV-2 infection. Ivermectin, as a partial agonist of glycine-gated chloride channels, was also recently suggested to interfere with the COVID-19 cytokine storm by inducing the activation of glycine receptors. Furthermore, plasma glycine levels are found to be decreased in diabetic patients. Thus, further clinical trials are warranted to confirm the potential favorable effects of targeting the SIT1 transporter and glycine levels in the treatment of COVID-19, particularly for the severe case of disease associated with hyperglycemia, inflammation, and T2D. These findings suggest that SIT1 may potentially represent one of the missing pieces in the complex puzzle observed between these two pandemic diseases and the potential novel target for their efficient treatment.

Abstract 13344: Beneficial Effects of Long-acting Nifedipine on Coronary Vasomotion Abnormalities After Drug-Eluting Stent Implantation -The NOVEL Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Ryuji Tsuburaya ◽  
Jun Takahashi ◽  
Akihiro Nakamura ◽  
Eiji Nozaki ◽  
Masafumi Sugi ◽  
...  
Keyword(s):  
Renin Angiotensin System ◽  
Quantitative Coronary Angiography ◽  
Drug Eluting Stent ◽  
Protective Effects ◽  
The Novel ◽  
Clinical Issue ◽  
Beneficial Effects ◽  
Coronary Vasomotion ◽  
Drug Eluting ◽  
Long Acting

Introduction: It is widely known that drug-eluting stents (DES) induce coronary vasomotion abnormalities. We have previously demonstrated that chronic treatment with long-acting nifedipine, which exerts cardiovascular protective effects through inhibition of vascular inflammation, suppresses DES-induced abnormal coronary vasoconstriction in pigs. In order to test whether this is also the case in humans, we performed a prospective, randomized, multicenter trial, termed as the NOVEL Study. Methods and Results: We enrolled 146 patients with stable angina pectoris who underwent elective implantation of everolimus-eluting stents (EES) in the left coronary arteries. They were randomly assigned to receive either conventional treatments alone (aspirin, clopidogrel, renin-angiotensin system inhibitor and statin) or additionally long-acting nifedipine (10-60 mg/day) (n=73 each). After 8-10 months, 53 patients in the control and 57 in the nifedipine group were finally examined for coronary reactivity to intracoronary acetylcholine (ACh) by quantitative coronary angiography after 48-hour withdrawal of nifedipine. Baseline patient characteristics and procedural profiles were comparable between the two groups. Coronary vasoconstricting responses to ACh were significantly enhanced at the distal segment adjacent to EES as compared with non-stented vessel (P<0.001) and were significantly inhibited in the nifedipine group (P<0.01) (Figure). Furthermore, the inflammatory profiles, including serum levels of high-sensitivity CRP and adiponectin, were improved only in the nifedipine group (P<0.05) (Figure). Conclusions: These results indicate that DES-induced coronary vasomotion abnormalities still remain an important clinical issue even with the second-generation of DES, for which long-acting nifedipine exerts beneficial effects associated with its anti-inflammatory effects.

Undergraduate Students’ Views on the Use of Online Learning Platform during COVID-19 Pandemic

TEKNOSASTIK ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 41
Author(s):  
Fatimah Mulya Sari ◽  
Lulud Oktaviani
Keyword(s):  
Online Learning ◽  
Undergraduate Students ◽  
Learning Process ◽  
The Novel ◽  
Beneficial Effects ◽  
Learning Platform ◽  
Learning Platforms ◽  
Novel Coronavirus

Technology-based online learning platforms have supported and helped Indonesian students to succeed the online learning education amid the novel coronavirus. They are allowed to access learning materials, learning activities, and learning practice for free. The purpose of this paper is to investigate the students’ paradigms on how effective is online learning platforms for their learning process. A qualitative method in form of a case study design was applied to this present study which had a hundred and eighty-five undergraduate students as the subjects. A questionnaire consisting of twenty-five statements was distributed to them through Google Forms. A follow-up interview via WhatsApp video calls was also conducted with the forty students who were chosen randomly to strengthen the findings. The results of this study show that most students agreed that the online learning platform might provide some beneficial effects for them. They mentioned that online activities through this platform were easily followed and challenge them to strive for keeping their balance motivation and interest to accomplish the online learning process. They were comfortable communicating and interacting with classmates and lecturers electronically. Besides, they might also be able to manage their study time and self-disciplined. Therefore, an online learning platform is considered to be a beneficial tool to support online learning environments.

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