Procalcitonin kinetics in pediatric patients with systemic inflammatory response after open heart surgery

2006 ◽  
Vol 32 (6) ◽  
pp. 881-887 ◽  
Author(s):  
Serdar Celebi ◽  
Ozge Koner ◽  
Ferdi Menda ◽  
Huriye Balci ◽  
Alican Hatemi ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Heart Surgery ◽  
Pediatric Patients ◽  
Open Heart Surgery ◽  
Systemic Inflammatory Response ◽  
Open Heart

Evaluation of Systemic Inflammatory Response in Cardiovascular Surgery via Interleukin-6, Interleukin-8, and Neopterin

2014 ◽  
Vol 17 (1) ◽  
pp. 13 ◽  
Author(s):  
Ihsan Sami Uyar ◽  
Suleyman Onal ◽  
Ayhan Uysal ◽  
Ugur Ozdemir ◽  
Oktay Burma ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Valve Replacement ◽  
Interleukin 6 ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Beating Heart ◽  
Systemic Inflammatory Response ◽  
The Other ◽  
Open Heart ◽  
Group 3

<p><b>Aim:</b> The aim of this study was to evaluate the serum levels of interleukin-6 (IL-6), IL-8, and neopterin as a sign of systemic inflammatory response syndrome after open-heart surgery. In this study, we evaluated the influences on the levels of IL-6, IL-8, and neopterin of coronary artery bypass grafting (CABG) and valve replacement surgeries with and without the use of extracorporeal circulation (ECC).</p><p><b>Materials and Methods:</b> This prospective study was performed in 30 patients. In this study, we evaluated patients who underwent valve replacement surgery (group 1, n = 10), CABG with ECC (group 2, n = 10), or CABG using the beating-heart technique (group 3, n = 10). With the Human Investigation Ethics Committee consent, blood samples were obtained from the patients before the surgery (T0) and after 1 hour (T1), 4 hours (T2), 24 hours (T3), and 48 hours (T4) of protamine injection. IL-6, IL-8, and neopterin levels were measured using commercial enzyme-linked immunosorbent assay kits.</p><p><b>Results:</b> The demographic data and preoperative and operative characteristics of the patients were similar. Neopterin IL-6 and IL-8 levels significantly increased first at the fourth hour after the surgery. When compared to the levels before the surgery, this increase was statistically significant. Unlike the other 2 groups of patients, those who experienced CABG with the beating-heart technique (group 3) had decreased neopterin levels at the first hour after the surgery, but this decrease was not statistically significant. Neopterin levels increased later in the OPCAB group, but these increased levels were not as high as the neopterin levels of groups 1 and 2. Neopterin reached maximum levels at the 24th hour and, unlike groups 1 and 2, in group started to decrease at the 48th.</p><p><b>Conclusions:</b> Complement activation, cytokine production, and related cellular responses are important factors during open-heart surgery. It is certain that ECC activates the complement systems, and activated complement proteins cause the production of several cytokines. In our study, neopterin levels in patients who underwent beating-heart method surgery were lower than those in the other groups, and these levels started to decrease at the 48th hour. These data suggest that the systemic inflammatory response was less activated in that patient group. The beating-heart method might be an important alternative in CABG surgery to minimize the complications and mortality related to surgery.</p>

The value of procalcitonin in systemic inflammatory response syndrome after open-heart surgery for CHD

2019 ◽  
Vol 29 (11) ◽  
pp. 1335-1339
Author(s):  
Kuntum Basitha ◽  
Rubiana Sukardi ◽  
Ratna Farida Soenarto ◽  
Suprayitno Wardoyo
Keyword(s):  
Platelet Count ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Systemic Inflammatory Response ◽  
Open Heart ◽  
Time Duration ◽  
Procalcitonin Level ◽  
Significant Difference

AbstractBakground:Systemic inflammatory response syndrome, which is marked by fever, is a possible complication after open-heart surgery for CHD. The inflammatory response following the use of cardiopulmonary bypass shows similar clinical signs with sepsis. Therefore serial measurements of procalcitonin, an early infection marker, can be helpful to differentiate between sepsis and systemic inflammatory response syndrome.Objectives:To evaluate serial levels of procalcitonin in children who underwent open-heart surgery for cyanotic and acyanotic CHD, and identify factors associated with elevated level of procalcitonin.Methods:Children and infants who had open-heart surgery and showed fever within 6 hours after surgery were recruited. Procalcitonin levels were serially measured along with leukocyte and platelet count. Other data were also recorded, including diagnosis, age, body weight, axillary temperature, aortic clamp time, bypass time, duration of mechanical ventilation, risk adjustment for congenital heart surgery score-1, and length of stay in Cardiac ICU. The patients were categorised into cyanotic and acyanotic CHD groups.Results:High mean of procalcitonin level suggested the presence of bacterial infection. Cyanotic CHD group had significantly higher mean of procalcitonin level compared to acyanotic CHD group in the first two measurements. Both groups had no leukocytosis, though platelet count results were significantly different between the two groups. There was no significant difference of procalcitonin level observed in culture results and adverse outcomes.Conclusion:Serial procalcitonin measurement can be helpful to determine the cause of fever. Meanwhile other conventional markers such as leukocyte and platelet should be assessed thoroughly.

scholarly journals P1655Preoperative predictors for systemic inflammatory response in open-heart surgery

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
E Viikinkoski ◽  
M Hollmen ◽  
J Jalkanen ◽  
J Gunn ◽  
J Airaksinen ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Systemic Inflammatory Response ◽  
Open Heart

Role of modified ultrafiltration in reduce of the systemic inflammatory response syndrome in cardiac surgery

2016 ◽  
Vol 7 (1) ◽  
pp. 106-110 ◽  
Author(s):  
Gennadiy G Khubulava ◽  
Sergey P Marchenko ◽  
Ekaterina V Dubova ◽  
Vitaliy V Suvorov
Keyword(s):  
Cardiac Surgery ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Inflammatory Mediators ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Systemic Circulation ◽  
Systemic Inflammatory Response ◽  
Mechanical Removal ◽  
The Moment

During open-heart surgery it is possible to disturbance of the barrier function and the appearance of inflammation in the systemic circulation of inflammatory mediators and pro-inflammatory cytokines, which is realized in the systemic inflammatory response syndrome (SIRS). To prevent the development of the condition, or to reduce the severity of its complications method of mechanical removal of inflammatory mediators and cytokines from the blood of the patient is the most efficient. At the moment, the problem of implementation of the systemic inflammatory response syndrome after surgery using cardiopulmonary bypass quite relevant because of the high frequency of its manifestations and adverse effects [18]. This explains the large number of studies aimed at both the study of the pathogenesis of systemic inflammatory response syndrome and the development of new methods to combat this phenomenon and the improvement of already applied methods and techniques [1, 4]. There are various ways to the reduction of the degree of systemic inflammatory response syndrome, but special attention is given to the study of methods of modified ultrafiltration and continuous veno-venous hemofiltration. Further study of the application of ultrafiltration on patients undergoing cardiac surgery heart surgery with the use of bypass is necessary for understanding of the physiology and pathophysiology of systemic inflammatory response syndrome induced by the conduct of bypass, as well as for the subsequent formulation of clinical guidelines for use in cardiac surgery practice. In this article we have tried to consider the most significant results of such studies.

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