Candidemia in non-neutropenic critically ill patients: analysis of prognostic factors and assessment of systemic antifungal therapy

1997 ◽  
Vol 23 (1) ◽  
pp. 23-30 ◽  
Author(s):  
J. Nolla-Salas ◽  
A. Sitges-Serra ◽  
C. León-Gil ◽  
J. Martínez-González ◽  
M. A. León-Regidor ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Critically Ill ◽  
Antifungal Therapy ◽  
Critically Ill Patients ◽  
Systemic Antifungal Therapy

Failure of Empirical Systemic Antifungal Therapy in Mechanically Ventilated Critically Ill Patients

2015 ◽  
Vol 191 (10) ◽  
pp. 1139-1146 ◽  
Author(s):  
Sébastien Bailly ◽  
Lila Bouadma ◽  
Elie Azoulay ◽  
Maité Garrouste Orgeas ◽  
Christophe Adrie ◽  
...  
Keyword(s):  
Critically Ill ◽  
Antifungal Therapy ◽  
Critically Ill Patients ◽  
Mechanically Ventilated ◽  
Systemic Antifungal Therapy

Systemic antifungal therapy in critically ill patients without invasive fungal infection*

2012 ◽  
Vol 40 (3) ◽  
pp. 813-822 ◽  
Author(s):  
Elie Azoulay ◽  
Hervé Dupont ◽  
Alexis Tabah ◽  
Olivier Lortholary ◽  
Jean-Paul Stahl ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Critically Ill ◽  
Antifungal Therapy ◽  
Invasive Fungal Infection ◽  
Critically Ill Patients ◽  
Systemic Antifungal Therapy

Outcomes associated with routine systemic antifungal therapy in critically ill patients with Candida colonization

2015 ◽  
Vol 41 (6) ◽  
pp. 1077-1088 ◽  
Author(s):  
David Ferreira ◽  
Frederic Grenouillet ◽  
Gilles Blasco ◽  
Emmanuel Samain ◽  
Thierry Hénon ◽  
...  
Keyword(s):  
Critically Ill ◽  
Antifungal Therapy ◽  
Critically Ill Patients ◽  
Candida Colonization ◽  
Systemic Antifungal Therapy

scholarly journals Prognostic Factors in Critically Ill Patients with Solid Tumours Admitted to an Oncological Intensive Care Unit

2010 ◽  
Vol 38 (2) ◽  
pp. 317-324 ◽  
Author(s):  
S. A. Ñamendys-Silva ◽  
J. Texcocano-Becerra ◽  
A. Herrera-Gómez
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Prognostic Factors ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Solid Tumours

scholarly journals The cancer control status and APACHE II score are prognostic factors for critically ill patients with cancer and sepsis

2020 ◽  
Vol 119 (1) ◽  
pp. 276-281
Author(s):  
Wei-Ke Kuo ◽  
Chung-Ching Hua ◽  
Chung-Chieh Yu ◽  
Yu-Chih Liu ◽  
Chih-Yu Huang
Keyword(s):  
Prognostic Factors ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Cancer Control ◽  
Apache Ii ◽  
Apache Ii Score ◽  
Patients With Cancer

scholarly journals 2113. Evaluation of Empiric Antifungal Therapy in Critically Ill Patients with Liver Disease, Sepsis, and No Evidence of Active Fungal Infection

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S715-S715
Author(s):  
Rachel S Britt ◽  
Monica V Mahoney ◽  
Howard Gold ◽  
Christopher McCoy
Keyword(s):  
Liver Disease ◽  
Fungal Infection ◽  
Clinical Outcomes ◽  
Critically Ill ◽  
Antifungal Therapy ◽  
Critically Ill Patients ◽  
Univariate Analysis ◽  
Organ Transplant ◽  
Unknown Origin ◽  
Inpatient Mortality

Abstract Background While candidemia is uncommon in the immunocompetent, critically ill population, it is associated with longer lengths of stay (LOS), higher cost, and higher mortality. In critically ill patients with liver disease and sepsis of unknown origin, antifungals (AF) are commonly used empirically. Recent studies suggest that this practice may not improve clinical outcomes but had little representation of patients with liver disease. This study aims to evaluate clinical outcomes of critically ill patients with liver disease, sepsis, and no evidence of active fungal infection who received empiric AF vs. those who did not. Methods This was a single-center, retrospective review of adults with liver disease and sepsis, identified by ICD-10 codes, who were discharged from the intensive care unit (ICU) between October 1, 2015 and December 31, 2018. Patients with neutropenia, marrow or organ transplant, HIV infection, systemic immunosuppressants, or fungal infection at sepsis onset were excluded. The primary outcome was inpatient mortality. Secondary outcomes included ICU LOS, total LOS, and development of fungal bloodstream infection (BSI) > 48 hours after sepsis onset. Fisher’s exact and Wilcoxon rank-sum tests were used to compare baseline characteristics. Multivariable logistic regression models were used to compare outcomes. Model covariates were variables with P-values < 0.2 in univariate analysis. Results A total of 119 patients were included with 92 receiving empiric AF (micafungin or fluconazole) and 27 receiving no AF. Patients receiving empiric AF were more likely to have hepatic disease upon admission and less likely to have a bacterial infection. Both groups were similar in intubation and vasopressor requirements, febrile episodes, and Candida score. Unadjusted inpatient mortality for empiric vs. no AF was 70.4% vs. 70.7%. Unadjusted ICU LOS, total LOS, and development of a fungal BSI were 10 vs. 11 days, 19 vs. 19 days, and 63.0% vs. 2.2% (P < 0.001). In multivariable models, there was no difference in inpatient mortality between groups (OR 1.20, 95% CI 0.77–1.63). Conclusion In critically ill patients with liver disease, sepsis, and no evidence of active fungal infection, receipt of empiric antifungal therapy did not improve inpatient mortality, ICU LOS, or total LOS but did reduce fungal BSI. Disclosures All authors: No reported disclosures.

Prognostic factors in critically ill patients with hematological malignancy admitted to the general intensive care unit: a single-center experience in Japan

2017 ◽  
Vol 31 (5) ◽  
pp. 736-743 ◽  
Author(s):  
Hiromasa Irie ◽  
Takanao Otake ◽  
Keiko Kawai ◽  
Masaaki Hino ◽  
Ayano Namazu ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Prognostic Factors ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Hematological Malignancy ◽  
General Intensive Care Unit ◽  
Single Center ◽  
Single Center Experience

scholarly journals Drivers and impact of antifungal therapy in critically ill patients with Aspergillus -positive respiratory tract cultures

2017 ◽  
Vol 50 (4) ◽  
pp. 529-535 ◽  
Author(s):  
J.A. Paiva ◽  
P. Mergulhão ◽  
A. Gomes ◽  
F.S. Taccone ◽  
A.-M. Van den Abeele ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Critically Ill ◽  
Antifungal Therapy ◽  
Critically Ill Patients

Outcomes of Critically Ill Gynecological Cancer Patients Admitted to Intensive Care Unit

2012 ◽  
Vol 30 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Silvio A. Ñamendys-Silva ◽  
María O. González-Herrera ◽  
Julia Texcocano-Becerra ◽  
Angel Herrera-Gómez
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Prognostic Factors ◽  
Mortality Rate ◽  
Hospital Mortality ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Gynecological Cancer ◽  
Apache Ii ◽  
Apache Ii Score

Purpose: To assess the characteristics of critically ill patients with gynecological cancer, and to evaluate their prognosis. Methods: Fifty-two critically ill patients with gynecological cancer admitted to intensive care unit (ICU) were included. Univariate and multivariate logistic regressions were used to identify factors associated with hospital mortality. Results: Thirty-five patients (67.3%) had carcinoma of the cervix uteri and 11 (21.2%) had ovarian cancer. The mortality rate in the ICU was 17.3% (9 of 52) and hospital mortality rate were 23%(12 of 52). In the multivariate analysis, independent prognostic factors for hospital mortality were vasopressor use (odds ratio [OR] = 8.60, 95% confidence interval [CI] 2.05-36; P = .03) and the Acute Physiology and Chronic Health Evaluation (APACHE) II score (OR = 1.43, 95% CI 1.01-2.09; P = .048). Conclusions: The independent prognostic factors for hospital mortality were the need for vasopressors and the APACHE II score.

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