In this paper, a multi-period turning interpolation algorithm, with real-time look-ahead scheme based on S-curve control method, is presented. In this interpolation algorithm, the geometric precision and the dynamic performance are both satisfied. The machining efficiency is improved by multi-period turning transition, and the precision is also improved by S-curve control method. The computational efficiency of this algorithm meets the need of real-time machining. In addition, there is no accumulated error. At last, this algorithm is verified the validation by the experiments on 3-axis CNC machine.