Quality of life in ambulatory postmenopausal women: the impact of reduced bone mineral density and subclinical vertebral fractures

2004 ◽  
Vol 15 (12) ◽  
pp. 975-980 ◽  
Author(s):  
Elisabetta Romagnoli ◽  
Vincenzo Carnevale ◽  
Italo Nofroni ◽  
Emilio D’Erasmo ◽  
Federica Paglia ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Mineral Density ◽  
The Impact

scholarly journals Quality of Life in Postmenopausal Women and Its Correlation with Bone Mineral Density

2015 ◽  
Vol 26 (3) ◽  
pp. 58-64
Author(s):  
C Zonunsanga ◽  
Hmingthanmawii LNU ◽  
Minggam Pertin ◽  
Chongreilen Chiru ◽  
Romi Singh Nongmaithem ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Significant Positive Association ◽  
The Mean

Abstract Aim To evaluate the quality of life in postmenopausal women and its correlation with bone mineral density. Study design Cross-sectional study. Duration of the study October 2012 to September 2014. Settings Physical Medicine and Rehabilitation Department, Regional Institute of Medical Sciences, Imphal. Study population Postmenopausal women who attended the department during the study period. Materials and Methods Quality of life was assessed using WHOQOL-BREF questionnaire, a validated brief version of the WHOQOL-100. Bone mineral density (BMD) in the lumbar spine, femoral neck and trochanter were measured using dual energy x-ray absorptiometry (DEXA) scan – GE Lunar model. Results A total of 125 patients were studied. The mean t-scores in lumbar spine, femoral neck and trochanter were -2.550 ± 1.209, -1.831 ± 0.921 and -1.621 ± 1.064 respectively. The mean BMD (g/cm2) in lumbar spine, femoral neck and trochanter were 0.867 ± 0.144, 0.789 ± 0.131 and 0.682 ± 0.139 respectively. The mean overall WHOQOL score was 57.68±10.07. There were statistically significant positive association of WHOQOL score with the BMDs in lumbar spine, femoral neck and trochanter (p < 0.05). Multivariate regression showed significant relation of overall WHOQOL score with BMD lumbar spine (b=0.229; R2=0.119), BMD femoral neck (b=0.285; R2=0.129), and BMD trochanter (b=0.245; R2=0.119). Conclusion BMDs in the lumbar spine, femoral neck and trochanter had a positive correlation with quality of life scores. BMD also had a good predictive value in determining the quality of life in postmenopausal women.

scholarly journals Social and mental functioning in postmenopausal women with low bone mineral density

2018 ◽  
Vol 71 (5-6) ◽  
pp. 171-179
Author(s):  
Jelena Zvekic-Svorcan ◽  
Martina Miklos ◽  
Karmela Filipovic ◽  
Milan Cvetkovic ◽  
Miljanka Vuksanovic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mental Functioning ◽  
Mineral Density ◽  
T Score ◽  
History Of

Introduction. Osteoporosis is a systemic, metabolic, progressive bone disease characterized by reduced bone mineral density leading to bone fragility and reduced quality of life. The objective of this study was to examine the quality of social and mental functioning in postmenopausal women with reduced mineral bone density. Material and Methods. This prospective cross-sectional study included 210 postmenopausal women aged ? 50 years, who were referred for osteodensitometry to the Special Hospital for Rheumatic Diseases Novi Sad, Serbia. The study was conducted in the period from February 24 to April 3, 2017. All women completed the Serbian version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (41). They all underwent bone mineral density measurement in two regions of interest, and the results were interpreted according to the current definition of osteoporosis. The participants? social and mental functioning was analyzed including the following variables: age, place of residence, educational attainment, employment, nutritional status, bone mineral density, and low-trauma fractures. Statistical processing and analyses were performed using Statistical Package for the Social Sciences, version 20. Results. A statistically significant negative correlation was noted between social functioning and the T-score for the femoral neck (r = -0.438), hip (r = -0.412) and spine (r = -0.226), as well as mental functioning with the T-score for the femoral neck (r = -0.424), hip (r = -0.454) and spine (r = -0.319). Patients with a history of fractures had a poorer quality of social functioning (t = 2.17, p < 0.05). Conclusion. The examinees of older age, with poor socio-demographic status, reduced bone mineral density, history of low-trauma fractures presented with lower quality of social and mental functioning.

The Impact of Smoking on Bone Metabolism, Bone Mineral Density and Vertebral Fractures in Postmenopausal Women

2020 ◽  
Vol 23 (3) ◽  
pp. 381-389 ◽  
Author(s):  
Caterina Trevisan ◽  
Agnese Alessi ◽  
Gaia Girotti ◽  
Bruno Micael Zanforlini ◽  
Anna Bertocco ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Mineral Density ◽  
The Impact

scholarly journals DINAMIKA MINERAL'NOY PLOTNOSTI KOSTI, MARKEROV KOSTNOGO OBMENA I KAChESTVA ZhIZNI PATsIENTOV S ENDOGENNYM GIPERKORTITsIZMOM POSLE DOSTIZhENIYa REMISSII ENDOGENNOGO GIPERKORTITsIZMA

2014 ◽  
Vol 17 (1) ◽  
pp. 16-20
Author(s):  
N V DRAGUNOVA ◽  
Zh E BELAYa ◽  
L Ya ROZhINSKAYa ◽  
N I SAZONOVA ◽  
T O ChERNOVA ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Mineral Density ◽  
Bone Remodeling ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Z Score ◽  
Active Stage ◽  
Mineral Density ◽  
Late Night

This study estimates the recovery of bone mineral density (BMD), markers of bone remodeling and quality of life in patients with endogenous Cushing’s syndrome (CS) after 12 months of achieving remission. Materials and methods: 21 patients with CS were prospectively evaluated at active stage of the disease and after being in a full remission (substitutional therapy with hydrocortisone or normal 24 hours urinary free cortisol (24h UFC) and late-night cortisol) during 12 months.A thoracic and lumbar X-ray was performed to reveal vertebral fractures. Bone mineral density (BMD) was measured by DXA ((Prodigy, Lunar, GE, USA). The level of 24h UFC was measured on a VitrosECi. Late-night serum cortisol and markers of bone remodeling were assayed by ECLIA Cobas e601 Roche. Patients fulfilled EQ-5D, ECOS-16 questionnaires and performed "up-and-go ”, "tandem ” and "chair-rising ” tests. Results: Among enrolled patients 17 (80%) were females and 4 (20%) - males; median of age (Q25-Q75) - 41 (33-49) years old; in 10 cases (48%) low traumatic fractures were diagnosed: 7 patients suffered from vertebral fractures; in 3 cases - ribs fractures. After the achieving remission no new fractures were registered and significant improvement in Z-score was reviled at all regions: L1-L4 -1,8 [-2,6; -0.5] at active stage vs -1,2 [-2,2; -0.5] after 12 months of remission (p=0.05); Neck Z-score -0,9 [-1,7; - 0,8] vs -0,7 [-1,6; -0,3], (p=0,003). The level of both bone metabolism markers increased: osteocalcin from 8,2 (6,912,0) to 22,7 (12,1-36,5) ng/ml (p=0,01) and CTx from 0,35 (0,22-0,63) to 0,7(0,28-1,05) ng/ml (p=0,01); whereas 24hUFC decreased from 1449 (926,4-2371) nmol/24h to 66,4(54,2-76,4) nmol/24h (p=0,01). The quality of life significantly improved at all dimensions if measured by ECOS-16. According to the EQ-5D patients suffered less from pain 1,35 (0,49) vs 1,12 (0,34), (p=0,04) and reported the improvement in their health (visual analogue scale) from 49 (18,9) to 68 (10,9), (p=0,004), but did not differ in others dimensions. Although 100% of patients admitted the improvement in their functional ability, the difference in functional tests did not reach statistical significance. Conclusions: Achieving the remission of CS improves BMD and quality of life in patients with CS. However, longer time is needed for full recovery, including the functional performance.

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