Differences of bone mass and bone structure in osteopenic rat models caused by spinal cord injury and ovariectomy

2007 ◽  
Vol 18 (6) ◽  
pp. 743-750 ◽  
Author(s):  
S.-D. Jiang ◽  
C. Shen ◽  
L.-S. Jiang ◽  
L.-Y. Dai
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Mass ◽  
Bone Structure ◽  
Rat Models ◽  
Cord Injury

scholarly journals Cell viability in three ex vivo rat models of spinal cord injury

2018 ◽  
Vol 234 (2) ◽  
pp. 244-251 ◽  
Author(s):  
Azim Patar ◽  
Peter Dockery ◽  
Linda Howard ◽  
Siobhan S. McMahon
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Viability ◽  
Ex Vivo ◽  
Rat Models ◽  
Cord Injury

scholarly journals Combination of defined CatWalk gait parameters for predictive locomotion recovery in experimental spinal cord injury rat models

eNeuro ◽  
2021 ◽  
pp. ENEURO.0497-20.2021
Author(s):  
Ivanna K. Timotius ◽  
Lara Bieler ◽  
Sebastien Couillard-Despres ◽  
Beatrice Sandner ◽  
Daniel Garcia-Ovejero ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Models ◽  
Experimental Spinal Cord Injury ◽  
Gait Parameters ◽  
Cord Injury

scholarly journals Exendin-4 improves neuron protection and functional recovery in experimental spinal cord injury in rats through regulating PCBP2 expression

2020 ◽  
Author(s):  
Huaichao Luo ◽  
Qingwei Wang ◽  
Lei Wang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Apoptosis ◽  
Sham Group ◽  
Sham Operation ◽  
Therapeutic Effects ◽  
Rat Models ◽  
Apoptosis Rate ◽  
Cord Injury ◽  
Group A

AbstractAimsIn the present research, we assessed the therapeutic effects of Exendin-4 (Ex-4) on rat models with spinal cord injury (SCI).Materials and methods36 male Sprague–Dawley rats were randomly allocated into three groups, including sham operation group, SCI group and SCI+Ex-4 group (Ex-4 treatment (10 µg/rat) after SCI, i.p.). In the SCI group, a laminectomy was performed at the T10 vertebrae, followed by weight-drop contusion of the spinal cord. In the sham group, a laminectomy was carried out without SCI contusion.Key findingsOur results showed that Basso-Beattie-Bresnahan scale scores were significantly decreased after SCI, and were obviously improved in SCI rats with Ex-4 administration. Additionally, the water content of spinal cord in SCI group was dramatically increased than that in sham group, and after Ex-4 treatment, degree of edema of spinal cord was remarkably reduced. And also, concentration levels of inflammatory cytokines (IL-1α, IL-1β, IL-6 and TNF-α) in the spinal cord were significantly elevated after SCI, and were remarkably reduced in SCI rats with Ex-4 administration. Subsequently, cell apoptosis rate in the injured spinal cord was significantly increased, and after Ex-4 treatment, cell apoptosis rate was remarkably decreased. We also revealed that levels of PCBP2 mRNA and protein were significantly up-regulated after SCI, and were dramatically dropped in SCI rats with Ex-4 administration.SignificanceTake altogether, our findings disclosed that Ex-4 plays a role in promoting neurological function recovery and inhibiting neuronal apoptosis through effecting PCBP2 expression in SCI rat models.

Exploring changes in bone mass in individuals with a chronic spinal cord injury

2020 ◽  
Author(s):  
R. El-Kotob ◽  
B.C. Craven ◽  
L. Thabane ◽  
A. Papaioannou ◽  
J.D. Adachi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Bone Mass ◽  
Chronic Spinal Cord Injury ◽  
Cord Injury

Experimental spinal cord trauma: a review of mechanically induced spinal cord injury in rat models

2017 ◽  
Vol 28 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Dauda Abdullahi ◽  
Azlina Ahmad Annuar ◽  
Masro Mohamad ◽  
Izzuddin Aziz ◽  
Junedah Sanusi
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Compression ◽  
Acute Injury ◽  
Optimal Timing ◽  
Spinal Cord Trauma ◽  
Rat Models ◽  
Human Spinal Cord ◽  
Cord Injury ◽  
Transient Force

AbstractIt has been shown that animal spinal cord compression (using methods such as clips, balloons, spinal cord strapping, or calibrated forceps) mimics the persistent spinal canal occlusion that is common in human spinal cord injury (SCI). These methods can be used to investigate the effects of compression or to know the optimal timing of decompression (as duration of compression can affect the outcome of pathology) in acute SCI. Compression models involve prolonged cord compression and are distinct from contusion models, which apply only transient force to inflict an acute injury to the spinal cord. While the use of forceps to compress the spinal cord is a common choice due to it being inexpensive, it has not been critically assessed against the other methods to determine whether it is the best method to use. To date, there is no available review specifically focused on the current compression methods of inducing SCI in rats; thus, we performed a systematic and comprehensive publication search to identify studies on experimental spinalization in rat models, and this review discusses the advantages and limitations of each method.

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