scholarly journals Reduced kidney function is associated with BMD, bone loss and markers of mineral homeostasis in older women: a 10-year longitudinal study

2017 ◽  
Vol 28 (12) ◽  
pp. 3463-3473 ◽  
Author(s):  
L. Malmgren ◽  
F. McGuigan ◽  
A. Christensson ◽  
K. E. Akesson
Keyword(s):  
Longitudinal Study ◽  
Bone Loss ◽  
Older Women ◽  
Kidney Function ◽  
Mineral Homeostasis ◽  
Reduced Kidney Function

scholarly journals Kidney function and its association to imminent, short- and long-term fracture risk—a longitudinal study in older women

2019 ◽  
Vol 31 (1) ◽  
pp. 97-107
Author(s):  
L. Malmgren ◽  
F.E. McGuigan ◽  
A. Christensson ◽  
K.E. Akesson
Keyword(s):  
Longitudinal Study ◽  
Fracture Risk ◽  
Older Women ◽  
Kidney Function ◽  
Short And Long Term

scholarly journals Longitudinal Study of Periodontal Disease and Edentulism With Rates of Bone Loss in Older Women

2005 ◽  
Vol 76 (1) ◽  
pp. 11-15 ◽  
Author(s):  
P. Famili ◽  
J. Cauley ◽  
J.B. Suzuki ◽  
R. Weyant
Keyword(s):  
Longitudinal Study ◽  
Bone Loss ◽  
Periodontal Disease ◽  
Older Women

scholarly journals Prevalence and health correlates of reduced kidney function among community-dwelling Chinese older adults: the China Health and Retirement Longitudinal Study

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e042396
Author(s):  
Haiyu Jin ◽  
Jingyi Zhou ◽  
Chenkai Wu
Keyword(s):  
Older Adults ◽  
Glomerular Filtration Rate ◽  
Longitudinal Study ◽  
Kidney Disease ◽  
Kidney Function ◽  
Cardiac Disease ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
South Central ◽  
Reduced Kidney Function

ObjectivesWe aimed to understand the prevalence of reduced kidney function in China by sociodemographics and geographical region, and to examine health correlates of reduced kidney function.DesignCross-sectional study.Setting and participantsParticipants were 6706 adults ≥60 years from the 2015–2016 wave of the China Health and Retirement Longitudinal Study.Outcome measuresReduced kidney function was defined as an estimated glomerular filtration rate of less than 60 mL/min per 1.73 m². The estimated glomerular filtration rate was calculated with the creatinine–cystatin C equation developed by the Chronic Kidney Disease Epidemiology Collaboration in 2012. The associations between reduced kidney function and potential risk factors were analysed using multivariable regression models.ResultsThe prevalence of reduced kidney function was 10.3% (95% CI: 9.3% to 11.2%), corresponding to approximately 20 million older adults. Multivariable analysis showed that older adults with hypertension (β=−3.61, 95% CI: −4.42 to 2.79), cardiac disease (β=−1.90, 95% CI: −2.93 to 0.86), who had a stroke (β=−3.75, 95% CI: −6.35 to 1.15), kidney disease (β=−3.88, 95% CI: −5.62 to 2.13), slow gait speed (β=−2.23, 95% CI: −3.27 to 1.20), and living in the South (β=−4.38, 95% CI: −5.95 to 2.80) and South Central (β=−1.85, 95% CI: −3.15 to 0.56) were more significantly likely to have reduced kidney function.ConclusionsKidney function screening should be performed, especially in patients with hypertension, cardiac disease and who had a stroke. More efforts should be paid to improve the kidney function of older adults living in the South and South Central parts of China.

Disease severity predicts bone loss: A longitudinal study in inflammatory bowel disease patients

2001 ◽  
Vol 120 (5) ◽  
pp. A628-A628
Author(s):  
S HENDERSON ◽  
S DHALIWAL ◽  
N HOFFMAN ◽  
R PRINCE
Keyword(s):  
Inflammatory Bowel Disease ◽  
Longitudinal Study ◽  
Bone Loss ◽  
Disease Severity ◽  
Bowel Disease ◽  
Inflammatory Bowel

Investigate Bone Loss in Older Women on AEDs

2005 ◽  
Vol 38 (8) ◽  
pp. 23
Author(s):  
BRUCE JANCIN
Keyword(s):  
Bone Loss ◽  
Older Women

scholarly journals Association of Treatment With Metformin vs Sulfonylurea With Major Adverse Cardiovascular Events Among Patients With Diabetes and Reduced Kidney Function

JAMA ◽  
2019 ◽  
Vol 322 (12) ◽  
pp. 1167 ◽  
Author(s):  
Christianne L. Roumie ◽  
Jonathan Chipman ◽  
Jea Young Min ◽  
Amber J. Hackstadt ◽  
Adriana M. Hung ◽  
...  
Keyword(s):  
Kidney Function ◽  
Cardiovascular Events ◽  
Major Adverse Cardiovascular Events ◽  
Patients With Diabetes ◽  
Reduced Kidney Function

scholarly journals SAT0477 A TWO-YEAR LONGITUDINAL STUDY COMPLETION, LONGITUNEAL STUDY, THE DIFFERENCE IN BONE LOSS IN PATIENTS WITH EROSIVE AND NON-EROSIVE HAND OSTEOARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1195.2-1195
Author(s):  
K. Pavelka ◽  
L. Šenolt ◽  
O. Sleglova ◽  
J. Baloun ◽  
O. Růžičková
Keyword(s):  
Bone Mineral Density ◽  
Longitudinal Study ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Bone Mineral ◽  
Hand Osteoarthritis ◽  
Mineral Density ◽  
Erosive Disease ◽  
Femur Neck ◽  
American College Of Rheumatology

Background:Hand osteoarthritis (OA) and its more severe subset erosive hand OA are common causes of pain and morbidity. Some metabolic factors were suggested to be implicated in erosive disease. Few studies investigated differences in systemic bone loss between erosive and non-erosive hand OA.Objectives:To compare the change of bone mineral density (BMD) between patients with erosive and non-erosive hand OA in a two-year longitudinal study.Methods:Consecutive patients with symptomatic HOA fulfilling the American College of Rheumatology (ACR) criteria were included in this study. Erosive hand OA was defined by at least one erosive interphalangeal joint. All patients underwent clinical assessments of joint swelling and radiographs of both hands. DEXA examination of lumbar spine, total femur and femur neck was performed at the baseline and after two years.Results:Altogether, 141patients (15 male) with symptomatic nodal HOA were included in this study and followed between April 2012 and January 2019. Out of these patients, 80 had erosive disease after two years. The disease duration (p<0.01) was significantly higher in patients with erosive compared with non-erosive disease at baseline.Osteoporosis (T-score <-2.5 SD) was diagnosed in 12.5% (9/72) of patients with erosive hand OA and in 8.06% (5/57) of patients with non-erosive hand OA at baseline. BMD was significantly lowered in patients with erosive compared with non-erosive disease at baseline (lumbar spine: 1.05g/cm2 vs. 1.13 g/cm2, p<0.05, total femur: 0.90 g/cm2 vs. 0.97 g/cm2, p<0.01 and femur neck: 0.86 g/cm2 vs. 0.91, p<0.05). T-scores of lumbar spine (-0.96 vs. -0.41 SD, p<0.05), total femur (-0.69 vs. -0.33 SD, p<0.05) and femur neck (-1.14 vs. -0.88 SD, p<0.05) were also significantly lowered in patients with erosive compared with non-erosive disease.Two years, the BMD remained also significantly lowered in patients with erosive compared with non-erosive disease (lumbar spine: 1.05g/cm2 vs. 1.14 g/cm2, p<0.05, total femur: 0.92 g/cm2 vs. 0.97 g/cm2, p<0.05 and femur neck: 0.86 g/cm2 vs. 0.91, p<0.05), which was in agreement with the finding for T-scores of lumbar spine (-1.05 vs. -0.39 SD, p<0.05), total femur (-0.74 vs. -0.34 SD, p<0.01) and femur neck (-1.07 vs. -0.72 SD, p<0.01).Conclusion:These results suggest that patients with erosive hand OA are at higher risk for the development of general bone loss. Over two years patients with erosive disease had significant lower bone mineral density at all measured sites.References:[1]This work was supported by the project AZV no. 18-00542 and MHCR No. 023728.Acknowledgments:Project AZV no. 18-00542 and MHCR No. 023728Disclosure of Interests:Karel Pavelka Consultant of: Abbvie, MSD, BMS, Egis, Roche, UCB, Medac, Pfizer, Biogen, Speakers bureau: Abbvie, MSD, BMS, Egis, Roche, UCB, Medac, Pfizer, Biogen, Ladislav Šenolt: None declared, Olga Sleglova: None declared, Jiří Baloun: None declared, Olga Růžičková: None declared

scholarly journals Reduced Kidney Function and Relative Hypocalciuria—Observational, Cross-Sectional, Population-Based Data

2020 ◽  
Vol 9 (12) ◽  
pp. 4133
Author(s):  
Massimo Cirillo ◽  
Giancarlo Bilancio ◽  
Pierpaolo Cavallo ◽  
Francesco Giordano ◽  
Gennaro Iesce ◽  
...  
Keyword(s):  
Kidney Function ◽  
Population Based ◽  
Calcium Handling ◽  
Urine Calcium ◽  
Cross Sectional ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Calcium Load ◽  
Reduced Kidney Function ◽  
Low Serum

This observational, cross-sectional, epidemiological analysis investigated relationships of kidney function to urine calcium and other variables. The analyses targeted two population-based samples of adults (Gubbio study and Moli-sani study: n = 3508 and 955, respectively). Kidney function was assessed as estimated glomerular filtration rate (eGFR). Calcium/creatinine ratio (Ca/Cr) was used as index of urinary calcium in timed overnight urine under fed condition (Gubbio study), morning urine after overnight fast (Gubbio study), and first-void morning urine (Moli-sani study). Moli-sani study included also data for glomerular filtered calcium load, tubular calcium handling, and serum phosphorus, parathyroid hormone, 1,25-dihydroxyvitamin D, calcium, and 25-hydroxyvitamin D. eGFR positively and independently related to Ca/Cr (p < 0.001). In multivariate analyses, eGFR lower by 10 mL/min × 1.73 m2 related to overnight urine Ca/Cr lower by 14.0 mg/g in men and 17.8 mg/g in women, to morning urine Ca/Cr lower by 9.3 mg/g in men and 11.2 mg/g in women, and to first-void urine Ca/Cr lower by 7.7 mg/g in men and 9.6 mg/g in women (p < 0.001). eGFR independently related to glomerular filtered calcium load (p < 0.001) and did not relate to tubular calcium handling (p ≥ 0.35). In reduced eGFR only (<90 mL/min × 1.73 m2), low urine Ca/Cr independently related to low serum 1,25-dihydroxyvitamin D (p = 0.002) and did not relate to hyperphosphatemia, high serum parathyroid hormone, or hypocalcemia (p ≥ 0.14). Population-based data indicated consistent associations of lower kidney function with lower urine calcium due to reduction in glomerular filtered calcium. In reduced kidney function, relative hypocalciuria associated with higher prevalence of low serum 1,25-dihydroxyvitamin D.

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