Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation

2009 ◽  
Vol 381 (3) ◽  
pp. 251-259 ◽  
Author(s):  
Niels Voigt ◽  
Nadiia Rozmaritsa ◽  
Anne Trausch ◽  
Thomasz Zimniak ◽  
Torsten Christ ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Efficacy ◽  
Antiarrhythmic Drugs ◽  
Class I ◽  
Class Iii

scholarly journals Clinical Efficacy of Bepridil for Class I Antiarrhythmic Drug-Induced Atrial Flutter in Patients with Paroxysmal Atrial Fibrillation

2008 ◽  
Vol 24 (2) ◽  
pp. 71-75
Author(s):  
Hidemori Hayashi ◽  
Masataka Sumiyoshi ◽  
Satoru Suwa ◽  
Hidehiko Sakurai ◽  
Yasunobu Kawano ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Atrial Flutter ◽  
Clinical Efficacy ◽  
Antiarrhythmic Drug ◽  
Paroxysmal Atrial Fibrillation ◽  
Class I ◽  
Drug Induced ◽  
Class I Antiarrhythmic Drug

scholarly journals Oral Class I and III antiarrhythmic drugs for maintaining sinus rhythm after catheter ablation of atrial fibrillation

2020 ◽  
Author(s):  
Mazhar Warraich ◽  
Christina Peter ◽  
Mahmood Ahmad ◽  
Shazaib Sheikh ◽  
George R Abraham ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Sinus Rhythm ◽  
Antiarrhythmic Drugs ◽  
Class I

scholarly journals The Frequency Analysis of Signal-Averaged ECG of P Wave as Predictor of Efficacy of Class III Antiarrhythmic Drugs to Maintain Sinus Rhythm in Recurrent Idiopathic Atrial Fibrillation

2001 ◽  
Vol 6 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Eduardo Corrêa Barbosa ◽  
Paulo Roberto Benchimol Barbosa ◽  
Paulo Ginefra ◽  
Alfredo Bomfim ◽  
Silvia Helena Cardoso Boghossian ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Rhythm ◽  
Frequency Analysis ◽  
Antiarrhythmic Drugs ◽  
P Wave ◽  
Class Iii ◽  
Maintain Sinus Rhythm

scholarly journals Hybrid Therapy of Class III Antiarrhythmic Drugs and Extensive Encircling Pulmonary Vein Isolation in Patient with Drug Resistant Very Long-Lasting Atrial Fibrillation

2011 ◽  
Vol 27 (Supplement) ◽  
pp. YIAC_2
Author(s):  
Masatsugu Ohe ◽  
Masahiko Goya ◽  
Kenichi Hiroshima ◽  
Kentaro Hayashi ◽  
Yu Makihara ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Pulmonary Vein Isolation ◽  
Antiarrhythmic Drugs ◽  
Drug Resistant ◽  
Class Iii ◽  
Hybrid Therapy

scholarly journals In Silico Assessment of Class I Antiarrhythmic Drugs Effects on Pitx2-induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues

2020 ◽  
Author(s):  
Jieyun Bai ◽  
Yijie Zhu ◽  
Andy Lo ◽  
Meng Gao ◽  
Yaosheng Lu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Antiarrhythmic Drugs ◽  
Ionic Currents ◽  
Tissue Level ◽  
Drug Binding ◽  
Class I ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Atrial Cells ◽  
Upstroke Velocity

Electrical remodelling as a result of the homeodomain transcription factor 2 (Pitx2)‐dependent gene regulation was linked to atrial fibrillation (AF) and AF patients with single nucleotide polymorphisms at chromosome 4q25 responded favorably to Class I antiarrhythmic drugs (AADs). The possible reasons behind this remain elusive. The purpose of this study was to assess the efficacy of AADs disopyramide, quinidine, and propafenone on human atrial arrhythmias mediated by Pitx2-induced remodelling, from a single cell to the tissue level, using drug binding models with multi-channel pharmacology. Experimentally calibrated populations of human atrial action potential (AP) models in both sinus rhythm (SR) and Pitx2-induced AF conditions were constructed by using two distinct models to represent morphological subtypes of AP. Multi-channel pharmacological effects of disopyramide, quinidine, and propafenone on ionic currents were considered. Simulated results showed that Pitx2-induced remodelling increased maximum upstroke velocity (dVdtmax) and conduction velocity (CV), and decreased AP duration (APD) and wavelength (WL). At the concentrations tested in this study, these AADs decreased dVdtmax and CV and prolonged APD in the setting of Pitx2-induced AF. Our findings of alterations in WL indicated that quinidine and disopyramide may be more effective against Pitx2-induced AF than propafenone by prolonging WL.

Abstract 9733: Atrial Fibrosis is Associated With Higher DC Cardioversion Failure Rates in Persistent Atrial Fibrillation

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Mohamed R Labedi ◽  
Abdulmohsin Ahmadjee ◽  
Mathias Koopman ◽  
Nassir Marrouche ◽  
Brent Wilson ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Drug Use ◽  
Sinus Rhythm ◽  
Univariate Analysis ◽  
Persistent Atrial Fibrillation ◽  
Class I ◽  
Class Iii ◽  
Atrial Fibrosis ◽  
Dc Cardioversion

Introduction: DC cardioversion (DCCV) is commonly performed in atrial fibrillation (AF). We examined the association between atrial fibrosis quantified using late gadolinium enhancement MRI (LGE-MRI) and acute success and recurrence of AF following DCCV. Methods: Persistent AF patients without previous catheter ablation who underwent LGE-MRI and DCCV were included in the study. Acute DCCV success was defined by achievement of sinus rhythm. Demographic patient data as well as comorbidities and medications were collected from chart revisions. Results: 241 patients were included (63% male). 186 patients (77.48%) were on oral anti-coagulation, 31 (12.9%) were on class I anti-arrhythmic drugs (AAD) and 46 (19.1%) were on class III AAD at the time of cardioversion. DCCV was acutely successful in 183 patients (75.9%). AF recurred after DCCV in 194 patients (80.5%) after an average follow up of 81 days. In univariate analysis, atrial fibrosis (HR 1.04; p=0.049) and body mass index (BMI) (HR 1.04; p=0.03) were associated with DCCV failure, while left atrial area, beta blocker, calcium channel blocker, class I and class III anti-arrhythmic drug use were not. In multivariate analysis, only atrial fibrosis was a significant predictor of DCCV failure (HR 1.03; p=0.03). During follow up, anti-arrhythmic drug use (class I drugs HR 0.21; p=0.045; class III drugs HR 0.27; p=0.042) was associated with maintenance of sinus rhythm. Conclusions: LGE-MRI quantified atrial fibrosis predicts failure of DCCV in persistent AF patients while AAD use was associated with maintenance of sinus rhythm.

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