Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain

2019 ◽  
Vol 392 (5) ◽  
pp. 573-583
Author(s):  
Stéphani Batista de Oliveira ◽  
Erika Ivanna Araya ◽  
Eder Gambeta ◽  
Luiz Eduardo Nunes Ferreira ◽  
Michele Franz-Montan ◽  
...  
Keyword(s):  
Animal Models ◽  
Orofacial Pain ◽  
Antinociceptive Effects

Animal Models of Orofacial Pain

2010 ◽  
pp. 93-104 ◽  
Author(s):  
Asma Khan ◽  
Kenneth M. Hargreaves
Keyword(s):  
Animal Models ◽  
Orofacial Pain

Chronic orofacial pain animal models - progress and challenges

2018 ◽  
Vol 13 (10) ◽  
pp. 949-964 ◽  
Author(s):  
Heitor G. Araújo-Filho ◽  
Erik W.M. Pereira ◽  
Adriana Rolim Campos ◽  
Lucindo J. Quintans-Júnior ◽  
Jullyana S.S. Quintans
Keyword(s):  
Animal Models ◽  
Orofacial Pain ◽  
Chronic Orofacial Pain

scholarly journals Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2453 ◽  
Author(s):  
Francesco Maione ◽  
Paola Minosi ◽  
Amalia Di Giannuario ◽  
Federica Raucci ◽  
Maria Giovanna Chini ◽  
...  
Keyword(s):  
Animal Models ◽  
Antinociceptive Effect ◽  
Binding Pocket ◽  
Docking Studies ◽  
Prostaglandin E ◽  
Single Administration ◽  
Antinociceptive Effects ◽  
Anti Inflammatory

The object of the study was to estimate the long-lasting effects induced by ammonium glycyrrhizinate (AG) after a single administration in mice using animal models of pain and inflammation together with biochemical and docking studies. A single intraperitoneal injection of AG was able to produce anti-inflammatory effects in zymosan-induced paw edema and peritonitis. Moreover, in several animal models of pain, such as the writhing test, the formalin test, and hyperalgesia induced by zymosan, AG administered 24 h before the tests was able to induce a strong antinociceptive effect. Molecular docking studies revealed that AG possesses higher affinity for microsomal prostaglandin E synthase type-2 compared to type-1, whereas it seems to locate better in the binding pocket of cyclooxygenase (COX)-2 compared to COX-1. These results demonstrated that AG induced anti-inflammatory and antinociceptive effects until 24–48 h after a single administration thanks to its ability to bind the COX/mPGEs pathway. Taken together, all these findings highlight the potential use of AG for clinical treatment of pain and/or inflammatory-related diseases.

Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae)

2016 ◽  
Vol 71 (7-8) ◽  
pp. 209-214 ◽  
Author(s):  
Juliane C. Silva ◽  
Larissa A.R.O. Macedo ◽  
Grasielly R. Souza ◽  
Raimundo G. Oliveira-Junior ◽  
Sarah R.G. Lima-Saraiva ◽  
...  
Keyword(s):  
Orofacial Pain ◽  
Antinociceptive Effect ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Upper Lip ◽  
Antinociceptive Effects ◽  
Rubbing Behavior ◽  
Pre Treatment ◽  
The Right ◽  
Orofacial Nociception

Abstract Annona vepretorum Mart. (Annonaceae) is a species popularly known in Brazil as “araticum” and “pinha da Caatinga”. We have evaluated the antinociceptive effects of A. vepretorum in formalin-, capsaicin-, and glutamate-induced orofacial nociception in mice. Male Swiss mice were pretreated with either saline (p.o.), A. vepretorum ethanol extract (Av-EtOH 25, 50 and 100 mg/kg, p.o.), or morphine (10 mg/kg, i.p.), before formalin, capsaicin, or glutamate was injected into the right upper lip. Pre-treatment with Av-EtOH at all doses produced a reduction in face-rubbing behavior induced by formalin in both phases, and these pre-treatments also produced a significant antinociceptive effect in the capsaicin and glutamate tests. Pre-treatment with naloxone (1.5 mg/kg, i.p.) did not reverse the antinociceptive activity of the extract at the dose of 100 mg/kg in the first phase of this test. Our results suggest that Av-EtOH might be useful in the treatment of orofacial pain.

Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain

2006 ◽  
Vol 10 (3) ◽  
pp. 241-241 ◽  
Author(s):  
Thomas Stöhr ◽  
Eva Krause ◽  
Norma Selve
Keyword(s):  
Animal Models ◽  
Inflammatory Pain ◽  
Antinociceptive Effects

Anti-Inflammatory and Antinociceptive Effects of Rosmarinus officinalis L. Essential Oil in Experimental Animal Models

2008 ◽  
Vol 11 (4) ◽  
pp. 741-746 ◽  
Author(s):  
I. Takaki ◽  
L.E. Bersani-Amado ◽  
A. Vendruscolo ◽  
S.M. Sartoretto ◽  
S.P. Diniz ◽  
...  
Keyword(s):  
Animal Models ◽  
Essential Oil ◽  
Experimental Animal ◽  
Rosmarinus Officinalis ◽  
Experimental Animal Models ◽  
Antinociceptive Effects ◽  
Anti Inflammatory ◽  
Rosmarinus Officinalis L

Anti-inflammatory and antinociceptive effects of the histamine H4-receptor antagonists in animal models of acute inflammation

2013 ◽  
Vol 65 ◽  
pp. 69-70
Author(s):  
Szczepan Mogilski ◽  
Monika Kubacka ◽  
Małgorzata Więcek ◽  
Katarzyna Kieć-Kononowicz ◽  
Barbara Filipek
Keyword(s):  
Animal Models ◽  
Acute Inflammation ◽  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
Antinociceptive Effects ◽  
Anti Inflammatory ◽  
H4 Receptor

scholarly journals Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study

2019 ◽  
Vol 52 (2) ◽  
Author(s):  
L.C.P. Cardoso ◽  
N.B. Pinto ◽  
M.E.P. Nobre ◽  
M.R. Silva ◽  
G.M. Pires ◽  
...  
Keyword(s):  
Experimental Study ◽  
Animal Models ◽  
Antinociceptive Effects ◽  
Anti Inflammatory

scholarly journals Potential Molecular Targets for Treating Neuropathic Orofacial Pain Based on Current Findings in Animal Models

2021 ◽  
Vol 22 (12) ◽  
pp. 6406
Author(s):  
Yukinori Nagakura ◽  
Shogo Nagaoka ◽  
Takahiro Kurose
Keyword(s):  
Animal Models ◽  
Trigeminal Nerve ◽  
Orofacial Pain ◽  
Signal Transmission ◽  
Molecular Targets ◽  
Biological Processes ◽  
Preclinical Research ◽  
Nerve Branch ◽  
Root Entry Zone ◽  
Trigeminal Root

This review highlights potential molecular targets for treating neuropathic orofacial pain based on current findings in animal models. Preclinical research is currently elucidating the pathophysiology of the disease and identifying the molecular targets for better therapies using animal models that mimic this category of orofacial pain, especially post-traumatic trigeminal neuropathic pain (PTNP) and primary trigeminal neuralgia (PTN). Animal models of PTNP and PTN simulate their etiologies, that is, trauma to the trigeminal nerve branch and compression of the trigeminal root entry zone, respectively. Investigations in these animal models have suggested that biological processes, including inflammation, enhanced neuropeptide-mediated pain signal transmission, axonal ectopic discharges, and enhancement of interactions between neurons and glial cells in the trigeminal pathway, are underlying orofacial pain phenotypes. The molecules associated with biological processes, whose expressions are substantially altered following trigeminal nerve damage or compression of the trigeminal nerve root, are potentially involved in the generation and/or exacerbation of neuropathic orofacial pain and can be potential molecular targets for the discovery of better therapies. Application of therapeutic candidates, which act on the molecular targets and modulate biological processes, attenuates pain-associated behaviors in animal models. Such therapeutic candidates including calcitonin gene-related peptide receptor antagonists that have a reasonable mechanism for ameliorating neuropathic orofacial pain and meet the requirements for safe administration to humans seem worth to be evaluated in clinical trials. Such prospective translation of the efficacy of therapeutic candidates from animal models to human patients would help develop better therapies for neuropathic orofacial pain.

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