Determination of Meserine, a new candidate for Alzheimer’s disease in mice brain by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic and tissue distribution study

2014 ◽  
Vol 406 (14) ◽  
pp. 3451-3458
Author(s):  
Zhaoxi Zheng ◽  
Yabin Tang ◽  
Haoyu Lv ◽  
Jianrong Xu ◽  
Hengyi Zhao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Tandem Mass ◽  
Distribution Study ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Mice Brain ◽  
Tissue Distribution Study

Determination of bosutinib in mice plasma and tissue by UPLC-MS/MS and its application to the pharmacokinetic and tissue distribution study

2015 ◽  
Vol 7 (21) ◽  
pp. 9184-9189 ◽  
Author(s):  
Linxia Wang ◽  
Luming Tang ◽  
Yi Zheng ◽  
Guoquan Pan ◽  
Wei Zhu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Internal Standard ◽  
Ultra Performance Liquid Chromatography ◽  
Tandem Mass ◽  
Distribution Study ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Tissue Distribution Study

A sensitive and rapid ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed to determine bosutinib in mice plasma and tissue using diazepam as the internal standard (IS).

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