Alcohol intoxication at 0.06 and 0.10% blood alcohol concentration changes segmental body movement coordination

Studies have demonstrated significant sex differences in alcohol intoxication effects. In contrast, the majority of studies on the alcohol hangover phase did not investigate sex differences. Therefore, the current study examined possible sex differences in the presence and severity of alcohol hangover symptoms. Data from n = 2446 Dutch students (male = 50.7%, female = 49.3%) were analyzed. They reported the presence and severity of 22 hangover symptoms experienced after their past month heaviest drinking occasion. Subjects were categorized according to their estimated peak blood alcohol concentration (eBAC) and presence and severity of the hangover symptoms were compared between men and women. In the lowest eBAC group (0% ≤ eBAC < 0.08%), no significant sex differences were found. In the subsequent eBAC group (0.08% ≤ eBAC < 0.11%), severity of nausea was significantly higher in women than in men. In the third eBAC group (0.11% ≤ eBAC < 0.2%), women reported higher severity scores on nausea, tiredness, weakness, and dizziness than men. Men reported the presence of confusion significantly more often than women, and women reported the presence of shivering significantly more often than men. In the fourth eBAC group (0.2% ≤ eBAC < 0.3%), women reported higher severity scores on nausea and tiredness than men. In the highest eBAC group (0.3% ≤ eBAC < 0.4%), no significant sex differences were found. In conclusion, across the eBAC groups, severity scores of nausea and tiredness were higher in women than in men. However, albeit statistically significant, the observed sex differences in presence and severity of hangover symptoms were of small magnitude, and therefore, have little clinical relevance.

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Blood alcohol concentration at 0.06 and 0.10% causes a complex multifaceted deterioration of body movement control

Alcohol ◽

10.1016/j.alcohol.2011.06.001 ◽

2012 ◽

Vol 46 (1) ◽

pp. 75-88 ◽

Cited By ~ 17

Author(s):

Fredrik Modig ◽

Per-Anders Fransson ◽

Måns Magnusson ◽

Mitesh Patel

Keyword(s):

Body Movement ◽

Blood Alcohol Concentration ◽

Movement Control ◽

Alcohol Concentration ◽

Blood Alcohol

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Blood alcohol concentration changes in laboratory samples during refrigerated storage

Digestive and Liver Disease ◽

10.1016/j.dld.2017.08.008 ◽

2017 ◽

Vol 49 (3) ◽

pp. e238

Author(s):

L. Abenavoli ◽

M. Maletin ◽

D. Stojic ◽

S. Brkic ◽

G. Stojiljkovic

Keyword(s):

Blood Alcohol Concentration ◽

Alcohol Concentration ◽

Blood Alcohol ◽

Refrigerated Storage ◽

Concentration Changes

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Auto-brewery syndrome: Ethanol pseudo-toxicity in diabetic and hepatic patients

Human & Experimental Toxicology ◽

10.1177/0960327116661400 ◽

2016 ◽

Vol 36 (5) ◽

pp. 445-450 ◽

Cited By ~ 9

Author(s):

EM Hafez ◽

MA Hamad ◽

M Fouad ◽

A Abdel-Lateff

Keyword(s):

Ethanol Production ◽

Metabolic Pathways ◽

Alcohol Intoxication ◽

Blood Alcohol Concentration ◽

Alcohol Concentration ◽

Gas Chromatography Mass Spectrometry ◽

Control Group ◽

Blood Alcohol ◽

Carbohydrate Ingestion ◽

Headspace Gas

Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (DM), liver cirrhosis (LC) and presence of both (DM and LC) on blood alcohol concentration (BAC) especially after carbohydrate ingestion. BAC has been measured by headspace gas chromatography-mass spectrometry in three groups of humans namely control, DM, LC and both (DM and LC) groups. The results showed that BAC in control group was 0.01–.3 mg/dL with mean 0.3 ± 0.41 mg/dL. In patients with DM, BAC is significantly higher than that of control group 4.85 ± 3.96 mg/dL. In patients with LC, BAC was 3.45 ± 2.65 mg/dL. In patients with both DM and LC, BAC increases to reach 10.88 ± 5.36 mg/dL. Endogenous ethanol production appears to increase in DM and LC. Also, it increased much more in patients with both diseases, but it did not reach toxic levels. On comparing BAC and blood glucose level in each group, all groups show insignificant correlations ( p > 0.05).

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Illegal substance use among 1,309 music festival attendees: An investigation using oral fluid sample drug tests, breathalysers and questionnaires

Scandinavian Journal of Public Health ◽

10.1177/1403494818821481 ◽

2019 ◽

Vol 47 (4) ◽

pp. 400-407 ◽

Cited By ~ 5

Author(s):

Linn Gjersing ◽

Anne Line Bretteville-Jensen ◽

Håvard Furuhaugen ◽

Hallvard Gjerde

Keyword(s):

Substance Use ◽

Oral Fluid ◽

Alcohol Intoxication ◽

Blood Alcohol Concentration ◽

Alcohol Concentration ◽

Blood Alcohol ◽

Dance Music ◽

Electronic Dance Music ◽

Music Festivals ◽

Concentration Levels

Aims: Illegal substance use at music festivals is less documented than it is in nightlife and electronic dance music settings. This study investigated such use through questionnaires, breathalysers and oral fluid drug testing. We also examined the associations between testing positive for illegal substances and demographics, self-reported substance use and measured blood alcohol concentration levels. Methods: A cross-sectional study of 1,309 festival attendees from six Norwegian music festivals taking place between July and August 2016. Logistic regression models estimated the likelihood of a positive oral fluid drug test. Covariates were male, age, education, employment, smoking status, early age for alcohol intoxication, alcohol intoxication ⩾2 times a week, past-month and past-year illegal substance use, blood alcohol concentration levels and festivals. Results: Overall, 12% reported illegal substance use in the past 30 days and 11% tested positive for illegal substances. Cannabis (6%), cocaine (3%) and MDMA/ecstasy (2%) were most commonly detected. One-third had a blood alcohol concentration ⩾0.10%. Of those with a positive test result ( n=146), 95% had detectable alcohol levels and 41% had a blood alcohol concentration above 0.10%. Those studying or working part-time were less likely to test positive compared to those who were not employed. Furthermore, those reporting daily smoking and past-year cannabis or MDMA/ecstasy use were more likely to test positive, compared to those not reporting such use. Conclusions: Illegal substance use was less prevalent than in previous nightlife and electronic dance music studies. Almost all those testing positive for illegal substances had detectable alcohol levels and 41% had a blood alcohol concentration greater than 0.10%, possibly indicating combined use.

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P.029 Self-estimation of blood alcohol concentration in patients admitted for acute alcohol intoxication in emergency department

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2020.09.032 ◽

2020 ◽

Vol 40 ◽

pp. S20

Author(s):

S. Cantin ◽

B. Angerville ◽

M. Naassila ◽

A. Dervaux

Keyword(s):

Emergency Department ◽

Alcohol Intoxication ◽

Blood Alcohol Concentration ◽

Alcohol Concentration ◽

Blood Alcohol ◽

Acute Alcohol Intoxication

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Absent substance use disorder and survival of extraordinarily high blood alcohol concentration

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.1747 ◽

2017 ◽

Vol 41 (S1) ◽

pp. s870-s870

Author(s):

M. Gahr ◽

H. Graf ◽

K. Malejko

Keyword(s):

Respiratory Depression ◽

Gastric Content ◽

Alcohol Intoxication ◽

Blood Alcohol Concentration ◽

Alcohol Concentration ◽

Blood Alcohol ◽

Psychotropic Agent ◽

Gag Reflex ◽

Competing Interest ◽

Very High

IntroductionIntoxications with alcohol are very frequent in clinical psychiatry and may lead to death depending on (maximum) blood alcohol concentration (BAC) and accompanying factors as liver function, tolerance, comedication, etc. Death may occur due to ethanol-induced respiratory depression and/or aspiration of gastric content (due to an impaired gag reflex); thus, securing of the airway and ventilation are occasionally necessary.Objectives/aimsTo illustrate the broad range of clinical outcomes of alcohol intoxications and their adequate therapy.MethodsWe present the case of a 58-year female patient with depression who demonstrated a very high BAC of 8.68 g/L (representing the highest survived BAC in literature) due to ingestion of large amounts of alcohol with suicidal intent.ResultsIntubation and ventilation were lifesaving and the patient did not develop any physical or mental consequential damage. As the patient had not regularly used alcohol or any other psychotropic agent tolerance could be ruled out.ConclusionsThis case emphasizes the necessity of rapid securing of the airway in patients with alcohol intoxication and respiratory depression and, furthermore, illustrates the large inter-individual differences regarding ethanol susceptibility.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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Sudden cardiac death and acute drunken state: Autopsy study

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1010590z ◽

2010 ◽

Vol 138 (9-10) ◽

pp. 590-594 ◽

Cited By ~ 2

Author(s):

Vladimir Zivkovic ◽

Borislav Miletic ◽

Slobodan Nikolic ◽

Fehim Jukovic

Keyword(s):

Sudden Cardiac Death ◽

Cardiac Death ◽

Alcohol Intoxication ◽

Blood Alcohol Concentration ◽

Alcohol Concentration ◽

Blood Alcohol ◽

Acute Alcohol Intoxication ◽

Natural Death ◽

Autopsy Study ◽

Alcohol Abusers

Introduction. Sudden natural death occurs unexpectedly in apparently healthy subjects, or in persons during an apparent benign phase in the course of disease. The most common cause is sudden cardiac death, which is sometimes the first and last manifestation of coronary heart disease. Alcohol directly influences excitation of myocytes, and therefore provokes arrhythmias and possibly, sudden cardiac death. Objective. To establish the frequency of sudden cardiac death in cases of acute alcohol intoxication, to determine blood alcohol concentration at the moment of death, and to determine frequency and level of ethanol intoxication in chronic alcohol abusers, as well as causes of sudden death in those cases. Method. Retrospective autopsy study was performed for a three-year-period. We analyzed cases of sudden natural death, in relation to age and gender, cause of death, and blood alcohol concentration (at least 0.5 g/L). We considered the person to be a chronic alcoholic abuser if gross examination of organs during autopsy showed changes typical for excessive and habitual alcohol consumption. Results. Our sample consisted of 997 cases: 720 men and 277 women, average age 62.0?15.2 years (min=11; max=98). Total of 753 of them died of sudden cardiac death: much more men (?2=167.364; p=0.000), significantly younger than women (t=6.203; p=0.000). We determined acute alcohol intoxication in 73 persons - average blood alcohol concentration 1.85?1.01 g/L (min=0.55; max=3.85), and 61 of them died of cardiovascular diseases (?2=236.781; df=5; p=0.000). Conclusion. In our observed sample, not many persons were under acute alcohol intoxication (around 7%). Most commonly, they were chronic alcohol abusers who died due to exacerbation of chronic heart disease, mildly or moderately intoxicated - the younger, the drunker.

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