Shoulder position and handedness differentially affect excitability and intracortical inhibition of hand muscles

2021 ◽  
Author(s):  
Shashwati Geed ◽  
Megan Grainger ◽  
Michelle L. Harris-Love ◽  
Peter S. Lum ◽  
Alexander W. Dromerick
Keyword(s):  
Intracortical Inhibition ◽  
Hand Muscles ◽  
Shoulder Position

Intracortical Inhibition During Volitional Inhibition of Prepared Action

2006 ◽  
Vol 95 (6) ◽  
pp. 3371-3383 ◽  
Author(s):  
James P. Coxon ◽  
Cathy M. Stinear ◽  
Winston D. Byblow
Keyword(s):  
Primary Motor Cortex ◽  
Motor Evoked Potentials ◽  
Short Interval ◽  
Intracortical Inhibition ◽  
Corticomotor Excitability ◽  
Hand Muscles ◽  
Cortical Level ◽  
A Site ◽  
Intrinsic Hand Muscles ◽  
Inhibitory Networks

Volitional inhibition is the voluntary prevention of a prepared movement. Here we ask whether primary motor cortex (M1) is a site of convergence of cortical activity associated with movement preparation and volitional inhibition. Volitional inhibition was studied by presenting a stop signal before execution of an anticipated response that requires a key lift to intercept a revolving dial. Motor evoked potentials (MEPs) were elicited in intrinsic hand muscles by transcranial magnetic stimulation (TMS) to assess corticomotor excitability and short interval intracortical inhibition (sICI) during task performance. The closer the stop cue was presented to the anticipated response, the harder it was for subjects to inhibit their response. Corticomotor pathway excitability was temporally modulated during volitional inhibition. Using subthreshold TMS, corticomotor excitability was reduced for Stop trials relative to Go trials from 140 ms after the cue. sICI was significantly greater for Stop trials compared with Go trials at a time that preceded the onset of muscle activity associated with the anticipated response. These results provide evidence that volitional inhibition is exerted at a cortical level and that inhibitory networks within M1 contribute to volitional inhibition of prepared action.

scholarly journals Physiological changes underlying bilateral isometric arm voluntary contractions in healthy humans

2011 ◽  
Vol 105 (4) ◽  
pp. 1594-1602 ◽  
Author(s):  
Demetris S. Soteropoulos ◽  
Monica A. Perez
Keyword(s):  
Tibialis Anterior ◽  
Motor Evoked Potentials ◽  
Short Interval ◽  
Intracortical Inhibition ◽  
Voluntary Contraction ◽  
Triceps Brachii ◽  
Hand Muscles ◽  
Healthy Humans ◽  
Simultaneous Activation ◽  
The Right

Many bilateral motor tasks engage simultaneous activation of distal and proximal arm muscles, but little is known about their physiological interactions. Here, we used transcranial magnetic stimulation to examine motor-evoked potentials (MEPs), interhemispheric inhibition at a conditioning-test interval of 10 (IHI10) and 40 ms (IHI40), and short-interval intracortical inhibition (SICI) in the left first dorsal interosseous (FDI) muscle during isometric index finger abduction. The right side remained at rest or performed isometric voluntary contraction with the FDI, biceps or triceps brachii, or the tibialis anterior. Left FDI MEPs were suppressed to a similar extent during contraction of the right FDI and biceps and triceps brachii but remained unchanged during contraction of the right tibialis anterior. IHI10 and IHI40 were decreased during contraction of the right biceps and triceps brachii compared with contraction of the right FDI. SICI was increased during activation of the right biceps and triceps brachii and decreased during activation of the right FDI. The present results indicate that an isometric voluntary contraction with either a distal or a proximal arm muscle, but not a foot dorsiflexor, decreases corticospinal output in a contralateral active finger muscle. Transcallosal inhibitory effects were strong during bilateral activation of distal hand muscles and weak during simultaneous activation of a distal and a proximal arm muscle, whereas GABAergic intracortical activity was modulated in the opposite manner. These findings suggest that in intact humans crossed interactions at the level of the motor cortex involved different physiological mechanisms when bilateral distal hand muscles are active and when a distal and a proximal arm muscle are simultaneously active.

scholarly journals Muscle Relaxation of the Foot Reduces Corticospinal Excitability of Hand Muscles and Enhances Intracortical Inhibition

2016 ◽  
Vol 10 ◽  
Author(s):  
Kouki Kato ◽  
Tetsuro Muraoka ◽  
Nobuaki Mizuguchi ◽  
Kento Nakagawa ◽  
Hiroki Nakata ◽  
...  
Keyword(s):  
Muscle Relaxation ◽  
Intracortical Inhibition ◽  
Corticospinal Excitability ◽  
Hand Muscles

scholarly journals Shoulder position and lesion location differentially affect hand muscle excitability and intracortical inhibition early post-stroke

2021 ◽  
Vol 14 (6) ◽  
pp. 1691-1692
Author(s):  
Shashwati Geed ◽  
Michelle Harris-Love ◽  
Megan Grainger ◽  
Harrish Ganesh ◽  
Matthew Edwardson ◽  
...  
Keyword(s):  
Intracortical Inhibition ◽  
Lesion Location ◽  
Post Stroke ◽  
Hand Muscle ◽  
Shoulder Position ◽  
Muscle Excitability

scholarly journals 2326

2017 ◽  
Vol 1 (S1) ◽  
pp. 62-62
Author(s):  
Shashwati Geed ◽  
Peter S. Lum ◽  
Michelle L. Harris-Love ◽  
Jessica Barth ◽  
Peter E. Turkeltaub ◽  
...  
Keyword(s):  
Muscle Activation ◽  
Intracortical Inhibition ◽  
Stroke Recovery ◽  
Chronic Patients ◽  
Corticomotor Excitability ◽  
Hand Muscles ◽  
Post Stroke ◽  
Clinical Recovery ◽  
Hand Muscle ◽  
Hand Coordination

OBJECTIVES/SPECIFIC AIMS: Upper-extremity (UE) impairment affects 88% of stroke survivors due to dysfunctional shoulder-hand coordination. Patients may be able to grasp with the arm at rest, but unable to grasp in a functional context (eg, from a high shelf) because shoulder use elicits involuntary hand muscle activity. Further, much rehabilitation research is directed at unsuccessful stroke recovery (patients with persistent UE impairment) but very little towards patients who show successful clinical recovery (such as those with mild UE impairment) even though these patients have attained the desired rehabilitation outcome. We examined the neurophysiological trajectory of successful compared to unsuccessful post-stroke recovery in the context of functional UE movements to clearly identify what factors are necessary for successful recovery of functional UE movements after stroke. METHODS/STUDY POPULATION: We studied 3 populations: (1) mildly-impaired patients, early (at <17 d, 30 d, 90 d, and 180 d) after stroke as a model of successful post-stroke recovery, (2) moderately-impaired, chronic patients (>6-months post stroke) with persistent hand function impairment, as a model of incomplete post-stroke recovery (unsuccessful recovery), and (3) Healthy age-range matched controls. We used transcranial magnetic stimulation (TMS) in all 3 groups at the given time points to measure corticomotor excitability (motor evoked potentials, recruitment curve), corticomotor inhibition (short-interval intracortical inhibition, long-interval intracortical inhibition), and intracortical facilitation of hand muscles with the shoulder positioned in different degrees of flexion or abduction (these shoulder positions are known to elicit involuntary, undesired hand muscle activation, which leads to UE dysfunction and impairment in individuals with stroke). RESULTS/ANTICIPATED RESULTS: Data collection are in process and will be presented. Preliminary data from controls shows that corticomotor excitability of selected hand muscles is affected by changes in shoulder position. Preliminary findings in controls are consistent with clinical findings in stroke that certain shoulder positions elicit involuntary and undesired hand muscle activation, leading to UE dysfunction and disability. Findings from the stroke groups will be presented. DISCUSSION/SIGNIFICANCE OF IMPACT: We hypothesize that this centrally-facilitated coupling between shoulder and hand muscles is disrupted after stroke, which may play a central role in the inability of patients to perform functional UE movements. By comparing the TMS metrics in mildly-impaired Versus moderately-impaired chronic patients, we will be able to identify the longitudinal change in neurophysiology underlying shoulder-hand coordination that is associated with successful or unsuccessful clinical recovery of UE function after stroke. Thus, these findings will help us distinguish between the neurophysiology underlying successful from unsuccessful UE recovery leading to more mechanism-based interventions for UE dysfunction post stroke in the future.

Effect of fatigue-related group III/IV afferent firing on intracortical inhibition and facilitation in hand muscles

2020 ◽  
Vol 128 (1) ◽  
pp. 149-158 ◽  
Author(s):  
Christopher Latella ◽  
Onno van der Groen ◽  
Cassio V. Ruas ◽  
Janet L. Taylor
Keyword(s):  
Short Interval ◽  
Intracortical Inhibition ◽  
Voluntary Activation ◽  
Intracortical Facilitation ◽  
Group Iii ◽  
Hand Muscles ◽  
Resting Motor Threshold ◽  
Before And After ◽  
Muscle Afferent ◽  
Related Group

Fatiguing exercise causes a reduction in motor drive to the muscle. Group III/IV muscle afferent firing is thought to contribute to this process; however, the effect on corticospinal and intracortical networks is poorly understood. In two experiments, participants performed sustained maximal isometric finger abductions of the first dorsal interosseous (FDI) muscle, with postexercise blood flow occlusion (OCC) to maintain the firing of group III/IV afferents or without occlusion (control; CON). Before and after exercise, single- and paired-pulse transcranial magnetic stimulation (TMS) tested motor evoked potentials (MEPs), intracortical facilitation [ICF (12 ms)], and short-interval intracortical inhibition [SICI2 (2 ms), SICI3 (3 ms)]. Ulnar nerve stimulation elicited maximal M waves (MMAX). For experiment 1 ( n = 16 participants), TMS intensities were 70% and 120% of resting motor threshold (RMT) for the conditioning and MEP stimuli, respectively. For experiment 2 ( n = 16 participants), the MEP was maintained at 1 mV before and after exercise and the conditioning stimulus individualized. In experiment 1, MEP/MMAX was reduced after exercise (~48%, P = 0.007) but was not different between conditions. No changes occurred in ICF or SICI. In experiment 2, MEP/MMAX increased (~27%, P = 0.027) and less inhibition (SICI2: ~21%, P = 0.021) occurred after exercise for both conditions, whereas ICF decreased for CON only (~28%, P = 0.006). MEPs and SICI2 were modulated by fatiguing contractions but not by group III/IV afferent firing, whereas sustained afferent firing appeared to counteract postexercise reductions in ICF in FDI. The findings do not support the idea that actions of group III/IV afferents on motor cortical networks contribute to the reduction in voluntary activation observed in other studies. NEW & NOTEWORTHY This is the first study to investigate, in human hand muscles, the action of fatigue-related group III/IV muscle afferent firing on intracortical facilitation and inhibition. In fatigued and nonexercised hand muscles, intracortical inhibition is reduced after exercise but is not modulated differently by the firing of group III/IV afferents. However, facilitation is maintained for the fatigued muscle when group III/IV afferents fire, but these results are unlikely to explain the reduction in voluntary activation observed in other studies.

P071 Intracortical inhibition and facilitation in discrete motor representations of hand muscles in frontal lobe

2008 ◽  
Vol 119 ◽  
pp. S89-S90
Author(s):  
Selja Teitti ◽  
Laura Säisänen ◽  
Mervi Könönen ◽  
Petro Julkunen ◽  
Taina Hukkanen ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Intracortical Inhibition ◽  
Hand Muscles ◽  
Motor Representations ◽  
Intracortical Inhibition And Facilitation

Intracortical Inhibition and Facilitation after congenital stroke

2006 ◽  
Vol 37 (01) ◽  
Author(s):  
S Berweck ◽  
V Brodbeck ◽  
M Walther ◽  
N Wagner ◽  
M Staudt ◽  
...  
Keyword(s):  
Intracortical Inhibition ◽  
Intracortical Inhibition And Facilitation

Effects of shoulder translation on lumbar moment for two dimensional modeling strategies during lifting

1998 ◽  
Vol 1 (3) ◽  
pp. 173-187
Author(s):  
Wayne J. Albert ◽  
Joan M. Stevenson ◽  
Geneviève A. Dumas ◽  
Roger W. Wheeler
Keyword(s):  
Sagittal Plane ◽  
Tracking System ◽  
Vertical Direction ◽  
Two Dimensional ◽  
Model Type ◽  
Trunk Acceleration ◽  
Analysis System ◽  
Trunk Orientation ◽  
Shoulder Position ◽  
Dynamic Link

The objectives of this study were to: 1) develop a dynamic 2D link segment model for lifting using the constraints of four sensors from an electromagnetic motion analysis system; 2) evaluate the magnitude of shoulder movement in the sagittal plane during lifting; and 3) investigate the effect of shoulder translation on trunk acceleration and lumbar moments calculated by the developed model and comparing it with two separate 2D dynamic link segment models. Six women and six men lifted loads of 2 kg, 7 kg, 12 kg and 2 kg, 12 kg, 22 kg respectively, under stoop, squat and freestyle conditions. Trunk orientation and position, as well as shoulder position were monitored during all lifts using the Polhemus FASTRAK\trdmk. Results indicated that average range of motion was 0.05 ± 0.02 m in the horizontal direction and 0.03 ± 0.02 m in the vertical direction. Shoulder position relative to T1 was located 0.07 ± 0.02 m anteriorly, and 0.02 ± 0.04 m superiorly (0.06 and 0.00 m for males and 0.08 and 0.04 m for females, respectively). To estimate the effect of shoulder motion on trunk acceleration and L5/S1 moments, three two-dimensional dynamic link segment models were developed within the constraints of the electromagnetic tracking system and compared. Trunk segment endpoints were defined as L5/S1 and either T1 or shoulder depending on model type. For trunk accelerations, average differences between models were greater than 40 deg/s² in 70.4% trunk accelerations did not translate into significantly different moment calculations between models. Average peak dynamic L5/S1 moment differences between models were smaller than 4 Nm for all lifting conditions which failed to be statistically significant (p>0.05). The model type did not have a statistically significant effect on peak L5/S1 moments. Therefore, despite important shoulder joint translations, peak L5/S1 moments were not significantly affected.

Sign in / Sign up

Export Citation Format

Share Document