Voltage-Gated calcium channels and nonvoltage-gated calcium uptake pathways in the rat incisor odontoblast plasma membrane

1997 ◽  
Vol 60 (1) ◽  
pp. 79-85 ◽  
Author(s):  
T. Lundgren ◽  
A. Linde
Keyword(s):  
Plasma Membrane ◽  
Calcium Channels ◽  
Calcium Uptake ◽  
Rat Incisor ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels

scholarly journals Two Voltage-Gated Calcium Channels Regulate Calcium Uptake in Murine Cardiac Mitochondria

2012 ◽  
Vol 102 (3) ◽  
pp. 162a
Author(s):  
Lukas Jaroslaw Motloch ◽  
Dennis Rottlaender ◽  
Tina Gebing ◽  
Martin Wolny ◽  
Sara Reda ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Calcium Uptake ◽  
Cardiac Mitochondria ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels

scholarly journals Trafficking of neuronal calcium channels

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Norbert Weiss ◽  
Gerald W. Zamponi
Keyword(s):  
Plasma Membrane ◽  
Calcium Channels ◽  
Intracellular Calcium ◽  
Dynamic Control ◽  
Surface Expression ◽  
Regulatory Mechanisms ◽  
Signalling Pathways ◽  
Physiological Functions ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels

Neuronal voltage-gated calcium channels (VGCCs) serve complex yet essential physiological functions via their pivotal role in translating electrical signals into intracellular calcium elevations and associated downstream signalling pathways. There are a number of regulatory mechanisms to ensure a dynamic control of the number of channels embedded in the plasma membrane, whereas alteration of the surface expression of VGCCs has been linked to various disease conditions. Here, we provide an overview of the mechanisms that control the trafficking of VGCCs to and from the plasma membrane, and discuss their implication in pathophysiological conditions and their potential as therapeutic targets.

Ca2+ controls gating of voltage-gated calcium channels by releasing the  2e subunit from the plasma membrane

2016 ◽  
Vol 9 (435) ◽  
pp. ra67-ra67 ◽  
Author(s):  
D.-I. Kim ◽  
H.-J. Kweon ◽  
Y. Park ◽  
D.-J. Jang ◽  
B.-C. Suh
Keyword(s):  
Plasma Membrane ◽  
Calcium Channels ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels

scholarly journals Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update

2021 ◽  
Vol 11 (8) ◽  
pp. 1035
Author(s):  
Maria Pia Giannoccaro ◽  
Patrizia Avoni ◽  
Rocco Liguori
Keyword(s):  
Potassium Channels ◽  
Neuromuscular Junction ◽  
Calcium Channels ◽  
Myasthenia Gravis ◽  
Neuromuscular Transmission ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Immune Mediated ◽  
Recent Developments ◽  
Myasthenic Syndrome

The neuromuscular junction (NMJ) is the target of a variety of immune-mediated disorders, usually classified as presynaptic and postsynaptic, according to the site of the antigenic target and consequently of the neuromuscular transmission alteration. Although less common than the classical autoimmune postsynaptic myasthenia gravis, presynaptic disorders are important to recognize due to the frequent association with cancer. Lambert Eaton myasthenic syndrome is due to a presynaptic failure to release acetylcholine, caused by antibodies to the presynaptic voltage-gated calcium channels. Acquired neuromyotonia is a condition characterized by nerve hyperexcitability often due to the presence of antibodies against proteins associated with voltage-gated potassium channels. This review will focus on the recent developments in the autoimmune presynaptic disorders of the NMJ.

scholarly journals Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal

2019 ◽  
Vol 216 (5) ◽  
pp. 250-253 ◽  
Author(s):  
Paul J. Harrison ◽  
Elizabeth M. Tunbridge ◽  
Annette C. Dolphin ◽  
Jeremy Hall
Keyword(s):  
Calcium Channels ◽  
Calcium Channel ◽  
Psychiatric Disorders ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Risk Genes ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Voltage Gated Calcium Channel ◽  
Second Use

SummaryWe reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.

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