Development of interferon beta-neutralising antibodies in multiple sclerosis—a systematic review and meta-analysis

2015 ◽  
Vol 71 (11) ◽  
pp. 1287-1298 ◽  
Author(s):  
Karthik Govindappa ◽  
Jean Sathish ◽  
Kevin Park ◽  
Jamie Kirkham ◽  
Munir Pirmohamed
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Interferon Beta ◽  
Meta Analysis ◽  
Neutralising Antibodies

scholarly journals Impact of disease-modifying therapies on MRI and neurocognitive outcomes in relapsing–remitting multiple sclerosis: a protocol for a systematic review and network meta-analysis

BMJ Open ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. e051509
Author(s):  
Samuel Lees ◽  
Mathew Dicker ◽  
Jie En Ku ◽  
Varun Chaganti ◽  
Matthew Mew-Sum ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Interferon Beta ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Disease Modifying Therapies ◽  
Relapsing Remitting ◽  
Neurocognitive Outcomes ◽  
Disease Modifying ◽  
Relapsing Remitting Multiple Sclerosis

IntroductionDisease-modifying therapies (DMTs) are the mainstay of treatment for relapsing–remitting multiple sclerosis (RRMS). There is established evidence that DMTs are effective at reducing relapse rate and disease progression in RRMS, but there has been less consideration to the synthesis of MRI and neurocognitive outcomes, which play an increasingly important role in treatment decisions. The aim of this systematic review and network meta-analysis is to examine the relative efficacy, acceptability and tolerability of DMTs for RRMS, using MRI and neurocognitive outcomes.Methods and analysisWe will search electronic databases, including MEDLINE, Embase and the Cochrane Central Register of Controlled Trials, with no date restrictions. We will also search the websites of international regulatory bodies for pharmaceuticals and international trial registries. We will include parallel group randomised controlled trials of DMTs including interferon beta-1a intramuscular, interferon beta-1a subcutaneous, interferon beta-1b, peginterferon beta-1a, glatiramer acetate, natalizumab, ocrelizumab, alemtuzumab, dimethyl fumarate, teriflunomide, fingolimod, cladribine, ozanimod, mitoxantrone and rituximab, either head-to-head or against placebo in adults with RRMS. Primary outcomes include efficacy (MRI outcomes including new T1/hypointense lesions and T2/hyperintense lesions) and acceptability (all-cause dropouts). Secondary outcomes include gadolinium-enhancing lesions, cerebral atrophy and tolerability (dropouts due to adverse events). Neurocognitive measures across three domains including processing speed, working memory and verbal learning will be included as exploratory outcomes. Data will be analysed using a random-effects pairwise meta-analysis and a Bayesian hierarchical random effects network meta-analysis to evaluate the efficacy, acceptability and tolerability of the included DMTs. Subgroup and sensitivity analyses will be conducted to assess the robustness of the findings. The review will be reported using the Preferred Reporting Items for Systematic Reviews incorporating Network Meta-Analyses statement.Ethics and disseminationThis protocol does not require ethics approval. Results will be disseminated in a peer-reviewed academic journal.PROSPERO registration numberCRD42021239630.

Serum Based miRNA as a Diagnostic Biomarker for Multiple Sclerosis: a Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-16
Author(s):  
Samar A. Zailaie ◽  
Jumana Jamal Siddiqui ◽  
Rawan Mansour Al Saadi ◽  
Dalia Mohammad Anbari ◽  
Amani S. Alomari ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Meta Analysis ◽  
Diagnostic Biomarker

scholarly journals The impact of physical exercise on the fatigue symptoms in patients with multiple sclerosis: a systematic review and meta-analysis

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Nazanin Razazian ◽  
Mohsen Kazeminia ◽  
Hossein Moayedi ◽  
Alireza Daneshkhah ◽  
Shamarina Shohaimi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Physical Exercise ◽  
Meta Analysis ◽  
The Impact

scholarly journals The Use of Noncontrast Quantitative MRI to Detect Gadolinium-Enhancing Multiple Sclerosis Brain Lesions: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 38 (7) ◽  
pp. 1317-1322 ◽  
Author(s):  
A. Gupta ◽  
K. Al-Dasuqi ◽  
F. Xia ◽  
G. Askin ◽  
Y. Zhao ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Meta Analysis ◽  
Brain Lesions ◽  
Quantitative Mri

Multiple sclerosis epidemiology in Asia and Oceania; A systematic review and meta-analysis

2021 ◽  
pp. 103119
Author(s):  
Ali Forouhari ◽  
Ghazale Taheri ◽  
Salari Mehri ◽  
Moosazadeh Mahmood ◽  
Masoud Etemadifar
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Meta Analysis ◽  
Multiple Sclerosis Epidemiology

Deep brain stimulation for multiple sclerosis tremor: A systematic review and meta-analysis

2021 ◽  
Vol 56 ◽  
pp. 103256
Author(s):  
Alireza Zali ◽  
Reza Jalili Khoshnood ◽  
Mahsa Motavaf ◽  
Alireza Salimi ◽  
Meisam Akhlaghdoust ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Meta Analysis ◽  
Deep Brain
Sign in / Sign up

Export Citation Format

Share Document