MIF plasma level as a possible tool to predict steroid responsiveness in children with idiopathic nephrotic syndrome

2019 ◽  
Vol 75 (12) ◽  
pp. 1675-1683
Author(s):  
Eva Cuzzoni ◽  
Raffaella Franca ◽  
Sara De Iudicibus ◽  
Annalisa Marcuzzi ◽  
Marianna Lucafò ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Plasma Level ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Responsiveness

Urinary Cytokines and Steroid Responsiveness in Idiopathic Nephrotic Syndrome of Childhood

2007 ◽  
Vol 28 (1) ◽  
pp. 83-90 ◽  
Author(s):  
Robert P. Woroniecki ◽  
Ibrahim F. Shatat ◽  
Katarina Supe ◽  
Zhongfang Du ◽  
Frederick J. Kaskel
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Responsiveness

scholarly journals Back to the Future: Therapies for Idiopathic Nephrotic Syndrome

2015 ◽  
Vol 39 (1-3) ◽  
pp. 105-109 ◽  
Author(s):  
Keisha L. Gibson ◽  
Dorey Glenn ◽  
Maria E. Ferris
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Molecular Targets ◽  
End Stage Kidney Disease ◽  
Risk Of Progression ◽  
Novel Targets ◽  
End Stage ◽  
Steroid Responsiveness

Background: Roughly 20-40% of individuals with idiopathic nephrotic syndrome will fail to respond to standard therapies and have a high risk of progression to end stage kidney disease (ESKD). In the last 50 years, no new therapies have been approved specifically for the treatment of these individuals with recalcitrant disease. Summary: Recent in vitro, translational, and clinical studies have identified novel targets and pathways that not only expand our understanding of the complex pathophysiology of proteinuric disease but also provide an opportunity to challenge the tradition of relying on histologic classification of nephrotic diseases to make treatment decisions. Key Messages: The traditional methods of directing the care of individuals with nephrotic syndrome by histological classification or deciding second line therapies on the basis of steroid-responsiveness may soon yield customizing therapies based on our expanding understanding of molecular targets. Important non-immunologic mechanisms of widely used immunosuppressive therapies may be just as important in palliating proteinuric disease as proposed immunologic functions.

scholarly journals Markers of disease and steroid responsiveness in paediatric idiopathic nephrotic syndrome: Whole-transcriptome sequencing of peripheral blood mononuclear cells

2017 ◽  
Vol 45 (3) ◽  
pp. 948-963 ◽  
Author(s):  
Hee Gyung Kang ◽  
Heewon Seo ◽  
Jae Hyun Lim ◽  
Jong Il Kim ◽  
Kyoung Hee Han ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Peripheral Blood Mononuclear Cells ◽  
Transcriptome Sequencing ◽  
Mononuclear Cells ◽  
Idiopathic Nephrotic Syndrome ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Whole Transcriptome Sequencing ◽  
Steroid Responsiveness ◽  
Whole Transcriptome

Objective To identify markers of disease and steroid responsiveness in paediatric idiopathic nephrotic syndrome. Methods Whole-transcriptome sequencing was performed of peripheral blood mononuclear cells (PBMCs) from patients with NS. Differentially expressed genes (DEGs) were identified in patients with active NS vs those in remission, and those with steroid-sensitive NS (SSNS) vs steroid-resistant NS (SRNS). Results A total of 1065 DEGs were identified in patients with NS ( n = 10) vs those in remission ( n = 9). These DEGs correlated with cytokine and/or immune system signalling and the extracellular matrix. Comparisons between SSNS ( n = 6) and SRNS ( n = 4) identified 1890 DEGs. These markers of steroid responsiveness were enriched with genes related to the cell cycle, targets of microRNAs, and genes related to cytokines. Conclusions Meaningful DEGs were identified. Additional studies with larger numbers of patients will provide more comprehensive data.

scholarly journals ACE I/D Gene Polymorphism Can't Predict the Steroid Responsiveness in Asian Children with Idiopathic Nephrotic Syndrome: A Meta-Analysis

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e19599 ◽  
Author(s):  
Tian-Biao Zhou ◽  
Yuan-Han Qin ◽  
Li-Na Su ◽  
Feng-Ying Lei ◽  
Wei-Fang Huang ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Gene Polymorphism ◽  
Idiopathic Nephrotic Syndrome ◽  
Meta Analysis ◽  
Asian Children ◽  
Steroid Responsiveness

scholarly journals Steroid Responsiveness of Children with Idiopathic Nephrotic Syndrome in Southeastern Region of Turkey

Renal Failure ◽  
2007 ◽  
Vol 29 (7) ◽  
pp. 855-859 ◽  
Author(s):  
Mehmet Davutoglu ◽  
Aydin Ece ◽  
Meki Bilici ◽  
Abdullah Dagli
Keyword(s):  
Nephrotic Syndrome ◽  
Idiopathic Nephrotic Syndrome ◽  
Steroid Responsiveness ◽  
Southeastern Region
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