scholarly journals Incidence, preventability, and causality of adverse drug reactions at a university hospital emergency department

2020 ◽  
Author(s):  
Mirjam Kauppila ◽  
Janne T. Backman ◽  
Mikko Niemi ◽  
Outi Lapatto-Reiniluoto
Keyword(s):  
Emergency Room ◽  
Patient Characteristics ◽  
Tertiary Hospital ◽  
University Hospital ◽  
Age Group ◽  
Emergency Room Visits ◽  
Hospital Emergency ◽  
Pharmacogenetic Testing ◽  
Severe Infections

Abstract Purpose To investigate the characteristics of ADRs in patients admitting at the emergency room of a tertiary hospital. Methods We collected the patient records of 1600 emergency room visits of a university hospital in 2018. The patient files were studied retrospectively and all possible ADRs were identified and registered. Patient characteristics, drugs associated with ADRs, causality, severity, preventability, and the role of pharmacogenetics were assessed. Results There were 125 cases with ADRs, resulting in a 7.8% overall incidence among emergency visits. The incidence was greatest in visits among elderly patients, reaching 14% (men) to 19% (women) in the 80–89 years age group. The most common causative drugs were warfarin, acetylsalicylic acid (ASA), apixaban, and docetaxel, and the most common ADRs were bleedings and neutropenia and/or severe infections. Only two of the cases might have been prevented by pharmacogenetic testing, as advised in Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. Conclusion The same ATC classes, antithrombotics and cytostatics, were involved in ADRs causing university clinic hospitalizations as those identified previously in drug-related hospital fatalities. It seems difficult to prevent these events totally, as the treatments are vitally important and their risk-benefit-relationships have been considered thoroughly, and as pharmacogenetic testing could have been useful in only few cases.

scholarly journals A first-year dornase alfa treatment impact on clinical parameters of patients with cystic fibrosis: the Brazilian cystic fibrosis multicenter study

2013 ◽  
Vol 31 (4) ◽  
pp. 420-430 ◽  
Author(s):  
Tatiana Rozov ◽  
Fernando Antônio A. e Silva ◽  
Maria Angélica Santana ◽  
Fabíola Villac Adde ◽  
Rita Heloisa Mendes
Keyword(s):  
Cystic Fibrosis ◽  
Emergency Room ◽  
Age Groups ◽  
Forced Expiratory Volume ◽  
First Year ◽  
Age Group ◽  
Emergency Room Visits ◽  
Dornase Alfa ◽  
Pulmonary Exacerbations ◽  
One Year

OBJECTIVE: To describe the clinical impact of the first year treatment with dornase alfa, according to age groups, in a cohort of Brazilian Cystic Fibrosis (CF) patients. METHODS: The data on 152 eligible patients, from 16 CF reference centers, that answered the medical questionnaires and performed laboratory tests at baseline (T0), and at six (T2) and 12 (T4) months after dornase alfa initiation, were analyzed. Three age groups were assessed: six to 11, 12 to 13, and >14 years. Pulmonary tests, airway microbiology, emergency room visits, hospitalizations, emergency and routine treatments were evaluated. Student's t-test, chi-square test and analysis of variance were used when appropriated. RESULTS: Routine treatments were based on respiratory physical therapy, regular exercises, pancreatic enzymes, vitamins, bronchodilators, corticosteroids, and antibiotics. In the six months prior the study (T0 phase), hospitalizations for pulmonary exacerbations occurred in 38.0, 10.0 and 61.4% in the three age groups, respectively. After one year of intervention, there was a significant reduction in the number of emergency room visits in the six to 11 years group. There were no significant changes in forced expiratory volume in one second (VEF1), in forced vital capacity (FVC), in oxygen saturation (SpO2), and in Tiffenau index for all age groups. A significant improvement in Shwachman-Kulczychi score was observed in the older group. In the last six months of therapy, chronic or intermittent colonization by P. aeruginosa was detected in 75.0, 71.4 and 62.5% of the studied groups, respectively, while S. aureus colonization was identified in 68.6, 66.6 and 41.9% of the cases. CONCLUSIONS: The treatment with dornase alfa promoted the maintenance of pulmonary function parameters and was associated with a significant reduction of emergency room visits due to pulmonary exacerbations in the six to 11 years age group, with better clinical scores in the >14 age group, one year after the intervention.

scholarly journals Septoplasty with and without additional sinonasal surgery: postoperative sequelae and the use of prophylactic antibiotics

2021 ◽  
Author(s):  
Ida Kotisalmi ◽  
Maija Hytönen ◽  
Antti A. Mäkitie ◽  
Markus Lilja
Keyword(s):  
Infection Rate ◽  
Postoperative Infection ◽  
Patient Characteristics ◽  
Neck Surgery ◽  
Prophylactic Antibiotics ◽  
University Hospital ◽  
Postoperative Infections ◽  
Prophylactic Measure ◽  
Prophylaxis Group

Abstract Purpose One of the most common complications after septoplasty is a postoperative infection. We investigated the number of postoperative infections and unplanned postoperative visits (UPV) in septoplasties with and without additional nasal surgery at our institution and evaluated the role of antibiotic prophylaxis. Methods We collected data of all consecutive 302 septoplasty or septocolumelloplasty patients operated during the year 2018 at the Department of Otorhinolaryngology-Head and Neck Surgery, HUS Helsinki University Hospital (Helsinki, Finland). Hospital charts were reviewed to record sociodemographic patient characteristics and clinical parameters regarding surgery and follow-up. Results Altogether 239 patients (79.1%) received pre- and/or postoperative prophylactic antibiotics and within this group 3.3% developed a postoperative infection. The infection rate in the non-prophylaxis group of 63 patients was 12.7% (p = 0.007). When all patients who received postoperative antibiotics were excluded, we found that the infection rate in the preoperative prophylaxis group was 3.8%, as opposed to an infection rate of 12.7% in the non-prophylaxis group (p = 0.013). When evaluating septoplasty with additional sinonasal surgery (n = 115) the rate of postoperative infection was 3.3% in the prophylaxis group and 16.7% in the non-prophylaxis group (p = 0.034). These results show a statistically significant stand-alone effect of preoperative prophylactic antibiotics in preventing postoperative infection in septoplasty, especially regarding additional sinonasal surgery. Conclusion The use of preoperative antibiotics as a prophylactic measure diminished statistically significantly the rate of infections and UPVs in septoplasty when all postoperative infections, superficial and mild ones included, were taken into account.

Emergency department presentations of people who are homeless: The role of occupational therapy

2017 ◽  
Vol 80 (9) ◽  
pp. 533-538 ◽  
Author(s):  
Chris Lloyd ◽  
Joanne Hilder ◽  
Philip Lee Williams
Keyword(s):  
Emergency Department ◽  
Occupational Therapy ◽  
Potential Role ◽  
Homeless People ◽  
Occupational Therapists ◽  
Age Group ◽  
Hospital Emergency ◽  
Liaison Officer ◽  
Drug And Alcohol

Introduction This project had two aims: to gain an understanding of the profile and expressed needs of people seen by the Homeless Emergency Department Liaison Officer in the emergency department in comparison to general hospital presentations, and to explore the potential role for occupational therapy to respond to this population. Method The Emergency Department Information Systems database and Homeless Emergency Department Liaison Officer files were examined to gather data on all individuals who presented to the hospital emergency department over a 16-month period. The viability of a discipline-specific role to respond to this population was then considered by senior occupational therapists. Results The results revealed that the majority of homeless people seen were male and in the early middle age group, with more than half arriving at the emergency department by way of ambulance services. The most common reasons for presentation were medical, mental health and drug- and alcohol-related issues. Conclusion It was found that a large percentage of people seen in the emergency department were discharged back to the streets. Senior occupational therapists have the potential to provide brief assessments and interventions that could reduce the ongoing demand on emergency department resources by people who are homeless.

Battered Women: A Medical Problem Requiring Detection

1978 ◽  
Vol 8 (2) ◽  
pp. 191-202 ◽  
Author(s):  
Bruce Rounsaville ◽  
Myrna M. Weissman
Keyword(s):  
Emergency Room ◽  
Battered Women ◽  
Psychiatric Treatment ◽  
Psychiatric Service ◽  
Medical Problem ◽  
University Hospital ◽  
Hospital Emergency ◽  
Surgical Services ◽  
Hospital Emergency Room ◽  
Nonpsychiatric Physician

A one month study of the surgical and psychiatric service of a university hospital emergency room identified thirty-seven women coming for treatment as a result of physical abuse. Thirty-three of the thirty-seven women presented at the surgical services and represented 3.8 per cent of surgical admissions in the emergency room. These women came from all ages, social and ethnic groups. They usually presented with contusions or other injuries to the head and neck. The majority would not accept psychiatric treatment but were willing to discuss the problem with the emergency room physician if encouraged. The preventive implications of these findings for the nonpsychiatric physician are discussed.

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