White-Coat and Reverse White-Coat Effects Correlate with 24-h Pulse Pressure and Systolic Blood Pressure Variability in Children and Young Adults

2015 ◽  
Vol 37 (2) ◽  
pp. 345-352 ◽  
Author(s):  
Hisayo Fujita ◽  
Seiji Matsuoka ◽  
Midori Awazu
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Systolic Blood Pressure ◽  
Pulse Pressure ◽  
Blood Pressure Variability ◽  
White Coat ◽  
Systolic Blood Pressure Variability ◽  
Children And Young Adults

Assessment of autonomic nervous system dysfunction and cardiovascular disease risk in young adults with intellectual disability

2020 ◽  
Author(s):  
Clara Christine Zwack ◽  
Rachael McDonald ◽  
Ainura Tursunalieva ◽  
Amali Cooray ◽  
Gavin W Lambert ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Nervous System ◽  
Young Adults ◽  
Intellectual Disability ◽  
Autonomic Nervous System ◽  
Systolic Blood Pressure ◽  
Autonomic Dysfunction ◽  
Blood Pressure Variability ◽  
Systolic Blood Pressure Variability

People with intellectual disability (ID) experience cardiometabolic related morbidity and mortality. However, it has been suggested that this population present and live with underestimated cardiovascular risk factors at a younger age, hence affecting their overall health, quality of life and contributing to early mortality. We assessed autonomic nervous system function in subjects with ID (n=39), aged 18-45 years, through measures of sudomotor function, heart rate and systolic blood pressure variability, and cardiac baroreflex function. Traditional clinical cardiovascular measurements and a biochemical analysis were also undertaken. We found that young adults with ID presented with sudomotor dysfunction, and impaired cardiac baroreflex sensitivity and systolic blood pressure variability, when compared to age-matched control subjects (n=38). Reduced hand and feet electrochemical skin conductance and asymmetry were significantly associated with having a moderate-profound ID. Autonomic dysfunction in those with ID persisted after controlling for age, sex and other metabolic parameters. Subjects in the ID group also showed significantly increased blood pressure, body mass index, waist/hip circumference ratio, and increased plasma haemoglobin A1c and high sensitivity C reactive protein. We conclude that autonomic dysfunction is present in young adults with ID and is more marked in those with more severe disability. These finding have important implications in developing preventative strategies to reduce the risk of cardiovascular disease in people with ID.

Long term habitual vigorous physical activity is associated with lower visit-to-visit systolic blood pressure variability

2020 ◽  
Author(s):  
Xiaoyong Xu ◽  
Xianghong Meng ◽  
Shin-ichi Oka
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Standard Deviation ◽  
Systolic Blood Pressure ◽  
Blood Pressure Variability ◽  
Vigorous Physical Activity ◽  
Systolic Blood Pressure Variability ◽  
Average Real Variability ◽  
Post Hoc

Abstract Objective Our work aimed to investigate the association between vigorous physical activity and visit-to-visit systolic blood pressure variability (BPV). Methods We conducted a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial), a well-characterized cohort of participants randomized to intensive (<120 mmHg) or standard (<140 mmHg) SBP targets. We assessed whether patients with hypertension who habitually engage in vigorous physical activity would have lower visit-to-visit systolic BPV compared with those who do not engage in vigorous physical activity. Visit-to-visit systolic BPV was calculated by standard deviation (SD), average real variability (ARV), and standard deviation independent of the mean (SDIM) using measurements taken during the 1-, 2-, 3-, 6-, 9- and 12-month study visits. A medical history questionnaire assessed vigorous physical activity, which was divided into three categories according to the frequency of vigorous physical activity. Results A total of 7571 participants were eligible for analysis (34.8% female, mean age 67.9±9.3 years). During a follow-up of 1-year, vigorous physical activity could significantly reduce SD, ARV, and SDIM across increasing frequency of vigorous physical activity. There were negative linear trends between frequency of vigorous physical activity and visit-to-visit systolic BPV. Conclusions Long-term engagement in vigorous physical activity was associated with lower visit-to-visit systolic BPV.

scholarly journals Correction: Prognostic impact of systolic blood pressure variability in people with diabetes

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0224538
Author(s):  
Katy J. L. Bell ◽  
Lamiae Azizi ◽  
Peter M. Nilsson ◽  
Andrew Hayen ◽  
Les Irwig ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Blood Pressure Variability ◽  
Prognostic Impact ◽  
Systolic Blood Pressure Variability

Feedback effects of circulating norepinephrine on sympathetic outflow in healthy subjects

2005 ◽  
Vol 288 (2) ◽  
pp. H710-H715 ◽  
Author(s):  
Mikko P. Tulppo ◽  
Heikki V. Huikuri ◽  
Elli Tutungi ◽  
Derek S. Kimmerly ◽  
Adrian W. Gelb ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Sympathetic Activity ◽  
Healthy Subjects ◽  
Blood Pressure Variability ◽  
Feedback Inhibition ◽  
Adrenergic Blockade ◽  
Sympathetic Outflow ◽  
Systolic Blood Pressure Variability ◽  
Normalized Units

The amplitude of low-frequency (LF) oscillations of heart rate (HR) usually reflects the magnitude of sympathetic activity, but during some conditions, e.g., physical exercise, high sympathetic activity results in a paradoxical decrease of LF oscillations of HR. We tested the hypothesis that this phenomenon may result from a feedback inhibition of sympathetic outflow caused by circulating norepinephrine (NE). A physiological dose of NE (100 ng·kg−1·min−1) was infused into eight healthy subjects, and infusion was continued after α-adrenergic blockade [with phentolamine (Phe)]. Muscle sympathetic nervous activity (MSNA) from the peroneal nerve, LF (0.04–0.15 Hz) and high frequency (HF; 0.15–0.40 Hz) spectral components of HR variability, and systolic blood pressure variability were analyzed at baseline, during NE infusion, and during NE infusion after Phe administration. The NE infusion increased the mean blood pressure and decreased the average HR ( P < 0.01 for both). MSNA (10 ± 2 vs. 2 ± 1 bursts/min, P < 0.01), LF oscillations of HR (43 ± 13 vs. 35 ± 13 normalized units, P < 0.05), and systolic blood pressure (3.1 ± 2.3 vs. 2.0 ± 1.1 mmHg2, P < 0.05) decreased significantly during the NE infusion. During the NE infusion after PHE, average HR and mean blood pressure returned to baseline levels. However, MSNA (4 ± 2 bursts/min), LF power of HR (33 ± 9 normalized units), and systolic blood pressure variability (1.7 ± 1.1 mmHg2) remained significantly ( P < 0.05 for all) below baseline values. Baroreflex gain did not change significantly during the interventions. Elevated levels of circulating NE cause a feedback inhibition on sympathetic outflow in healthy subjects. These inhibitory effects do not seem to be mediated by pressor effects on the baroreflex loop but perhaps by a presynaptic autoregulatory feedback mechanism or some other mechanism that is not prevented by a nonselective α-adrenergic blockade.

Learned Control of Heart Rate and Blood Pressure

1971 ◽  
Vol 33 (1) ◽  
pp. 219-226 ◽  
Author(s):  
Michael Hnatiow
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Blood Pressure Variability ◽  
Visual Display ◽  
Waveform Analysis ◽  
Target Range ◽  
Heart Rates ◽  
Systolic Blood Pressure Variability ◽  
Continuous Measures

Cardiac rate-variability control and an initial demonstration of systolic blood-pressure variability control using visual feedback of physiological information were examined. Continuous measures of respiration, heart rate, EXG waveform analysis, and systolic blood pressure were obtained for both experimental groups and for yoked controls who saw the same visual display as the experimental Ss. Ss successful at reducing heart-rate variability showed clear changes in the P-R wave relationships of the EKG, indicating possible direct attempts to manipulate heart rate so as to reduce variability. Ss controlling blood-pressure variability who had high heart rates were more successful in reducing variability than those with low rates, possibly because of differential feedback to Ss with high and low heart rates. In addition, apparently as a reaction to E's adjustment of the visual target range, experimental Ss showed decreases in mean blood-pressure levels.

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