Assessing the Association of Kawasaki Disease Symptoms and Echocardiographic Findings

2021 ◽  
Author(s):  
Seyed Hesamedin Nabavizadeh ◽  
Nima Mehdizadegan ◽  
Mohsen Moeini ◽  
Soheila Alyasin ◽  
Hossein Esmaeilzadeh ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Disease Symptoms ◽  
Echocardiographic Findings

scholarly journals Effect of COVID-19 on Kawasaki Disease: Decrease Age of Onset and Increase Skin Manifestation

2021 ◽  
Author(s):  
Hossein Esmaeilzadeh ◽  
Negar Mortazavi ◽  
Alireza Salehi ◽  
Hossein Fatemian ◽  
Seyed Mohsen Dehghani ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Clinical Laboratory ◽  
Age Of Onset ◽  
P Value ◽  
Skin Manifestation ◽  
Significant Difference ◽  
Acquired Heart Disease ◽  
Apparent Reason ◽  
Childhood Vasculitis ◽  
Echocardiographic Findings

Abstract Kawasaki Disease (KD) is most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children.ObjectiveWe performed this study to assess the association between KD and COVID-19.Methods and MaterialsWe evaluated KD hospitalized children during February to September 2020 for COVID-19 (group one) and compared their demographic, clinical, laboratory, and echocardiographic findings with KD patients from the same period time in 2019 (group two). We also compared the same data in COVID-19 positive and COVID-19 negative KD patients in 2020 pandemic period.ResultsSixty eight percent of group one KD patients were positive for COVID-19 during the pandemic period. KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value= 0.044). There was no difference in the demographic, clinical, laboratory, and echocardiographic features of the patients during and before the COVID-19 pandemic (p-value > 0.05). Moreover, Comparing COVID-19 positive and negative patients, the incidence of rash was higher within COVID-19 positive cases (p<0.05), and coronary artery abnormalities were more prevalent in COVID-19 negative cases (p < 0.05).ConclusionAdmission rate of KD does not have significant difference during the COVID-19 pandemic but 68% of KD admitted patient were COVID-19 positive. Age of onset for KD during the COVID-19 pandemic was lower and skin manifestation was higher than the same period time in last year.

scholarly journals Association of Kawasaki Disease and COVID-19 in children

2021 ◽  
Author(s):  
hossein esmaeilzadeh ◽  
Negar Mortazavi ◽  
Alireza Salehi ◽  
Hossein Fatemian ◽  
Hossein Molavi Vardanjani
Keyword(s):  
Kawasaki Disease ◽  
Clinical Laboratory ◽  
Age Of Onset ◽  
Admission Rate ◽  
P Value ◽  
Significant Difference ◽  
Acquired Heart Disease ◽  
Apparent Reason ◽  
Childhood Vasculitis ◽  
Echocardiographic Findings

Abstract Kawasaki Disease (KD) is most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children. Objective We performed this study to assess the association between KD and COVID-19. Methods and Materials We evaluated KD hospitalized children during February to September 2020 for COVID-19 (group one) and compared their demographic, clinical, laboratory, and echocardiographic findings with KD patients from the same period of time in 2019 (group two). We also compared the same data in COVID-19 positive and COVID-19 negative KD patients in 2020 pandemic period. Results 68% of KD patients in group one were positive for COVID-19 during the pandemic period. KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value= 0.044). There was no difference in the demographic, clinical, laboratory, and echocardiographic features of the patients during and before the COVID-19 pandemic (p-value > 0.05). Moreover, Comparing COVID-19 positive and negative patients, the incidence of rash was higher within COVID-19 positive cases (p<0.05), and coronary artery abnormalities were more prevalent in COVID-19 negative cases (p < 0.05). Conclusion Admission rate of KD does not have significant difference during the COVID-19 pandemic but 68% of KD admitted patient were COVID-19 positive. Age of onset for KD during the COVID-19 pandemic was lower than the same period of time in last year.

scholarly journals Atypical Kawasaki disease in an early infant, a diagnostic challenge: Case report

2021 ◽  
Vol 8 (11) ◽  
pp. 394-396
Author(s):  
Kaifi Siddiqui ◽  
Ayub Ansari ◽  
Ishaq Farooq ◽  
Sheeba Farooqui
Keyword(s):  
Kawasaki Disease ◽  
Leukocyte Count ◽  
Intravenous Immunoglobulins ◽  
Total Leukocyte Count ◽  
C Reactive Protein ◽  
Diagnostic Challenge ◽  
Reactive Protein ◽  
Atypical Kawasaki Disease ◽  
Short Courses ◽  
Echocardiographic Findings

A 4.5-month-old girl presented to us with continuous fever for 10 days and loose stools for 2 days. She received short courses of multiple oral antibiotics during this period however, was not relieved. Initial investigations were suggestive of urinary tract infection for which broad spectrum antibiotics were started. However, fever persisted even after 72 h of antibiotics. Blood counts showed persistently high total leukocyte count and increasing platelet count, along with high C-reactive protein. Consequently, a diagnosis of Kawasaki disease (KD) was suspected, which was supported by echocardiographic findings. After she received intravenous immunoglobulins, her fever subsided and lab parameters showed significant improvement. This case highlights an unusual presentation of KD in an uncommonly young age group without much clinical pointers except for persistent fever.

scholarly journals Usefulness of echocardiographic findings in the early diagnosis of Kawasaki disease

2007 ◽  
Vol 50 (1) ◽  
pp. 47 ◽  
Author(s):  
Chang Hwan Choi ◽  
Sung Hwan Byun ◽  
Je Duk Jeon ◽  
Jong-Woon Choi
Keyword(s):  
Kawasaki Disease ◽  
Early Diagnosis ◽  
Echocardiographic Findings

scholarly journals Association of Kawasaki Disease and COVID-19 in children

2021 ◽  
Author(s):  
hossein esmaeilzadeh ◽  
Negar Mortazavi ◽  
Alireza Salehi ◽  
Hossein Fatemian ◽  
Hossein Molavi Vardanjani
Keyword(s):  
Kawasaki Disease ◽  
Clinical Laboratory ◽  
Age Of Onset ◽  
P Value ◽  
Infectious Agents ◽  
Significant Difference ◽  
Acquired Heart Disease ◽  
Apparent Reason ◽  
Childhood Vasculitis ◽  
Echocardiographic Findings

Abstract Kawasaki Disease (KD) is most common childhood vasculitis and cause of acquired heart disease for no apparent reason. There is some evidence indicating infectious agents as possible triggers for KD. During the COVID-19 pandemic, vasculitis has been a presentation of COVID-19 in children.ObjectiveWe performed this study to assess the association between KD and COVID-19.Methods and MaterialsWe evaluated KD hospitalized children during February to September 2020 for COVID-19 (group one) and compared their demographic, clinical, laboratory, and echocardiographic findings with KD patients from the same period of time in 2019 (group two). We also compared the same data in COVID-19 positive and COVID-19 negative KD patients in 2020 pandemic period.Results68% of KD patients in group one were positive for COVID-19 during the pandemic period. KD Age of onset in the group one was lower than group two (4.38 years VS 5.5 years, P-value= 0.044). There was no difference in the demographic, clinical, laboratory, and echocardiographic features of the patients during and before the COVID-19 pandemic (p-value > 0.05). Moreover, Comparing COVID-19 positive and negative patients, the incidence of rash was higher within COVID-19 positive cases (p<0.05), and coronary artery abnormalities were more prevalent in COVID-19 negative cases (p < 0.05).ConclusionAdmission rate of KD does not have significant difference during the COVID-19 pandemic but 68% of KD admitted patient were COVID-19 positive. Age of onset for KD during the COVID-19 pandemic was lower than the same period of time in last year.

scholarly journals Atypical Kawasaki disease

2016 ◽  
Vol 69 (1-2) ◽  
pp. 53-57 ◽  
Author(s):  
Ljiljana Ristovski ◽  
Olgica Milankov ◽  
Melanija Vislavski ◽  
Radojica Savic ◽  
Milena Bjelica
Keyword(s):  
Kawasaki Disease ◽  
Coronary Arteries ◽  
Clinical Signs ◽  
Artery Aneurysm ◽  
Cardiac Complications ◽  
Incomplete Kawasaki Disease ◽  
Coronary Abnormalities ◽  
Unexplained Fever ◽  
Atypical Kawasaki Disease ◽  
Echocardiographic Findings

Introduction. Kawasaki disease is an acute vasculitis which occurs primarily in children under the age of 5. The etiology of the disease is still unknown. Diagnostic criteria for Kawasaki disease are fever and at least four of the five additional clinical signs. Incomplete Kawasaki disease should be taken into consideration in case of all children with unexplained fever for more than 5 days, associated with 2 or 3 of the main clinical findings of Kawasaki disease. The diagnosis of incomplete Kawasaki disease is based on echocardiographic findings indicating the involvement of the coronary arteries. Cardiac complications, mostly coronary artery aneurysm, can occur in 20% to 25% of untreated patients and in 4% of treated patients. Case Report. In this report we present a case of atypical Kawasaki disease in a 3.5-month-old infant. As soon as the diagnosis was made, the patient received high doses of intravenous immunoglobulin, with the initial introduction of ibuprofen, then aspirin with a good clinical response. Due to the presence of aneurysm of coronary arteries, further therapy involved aspirin and clopidogrel over the following 3 months, and then only aspirin for 2 years. There was a gradual regression of the changes in the coronary blood vessels to the normalization of the echocardiographic findings after 2 years. Conclusion. Kawasaki disease is the second most common vasculitis of childhood, so it should be included in the differential diagnosis for any child with a prolonged unexplained fever. Atypical Kawasaki disease should be taken into consideration in cases when not all clinical criteria are present but coronary abnormalities are documented.

scholarly journals Analysis of factors associated with development of Bacille Calmette–Guérin inoculation site change in patients with Kawasaki disease

2018 ◽  
Vol 46 (4) ◽  
pp. 1640-1648 ◽  
Author(s):  
Tooru Araki ◽  
Aya Kodera ◽  
Kunimi Kitada ◽  
Michimasa Fujiwara ◽  
Michiko Muraoka ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Clinical Severity ◽  
Bacille Calmette Guerin ◽  
Bcg Vaccination ◽  
Factors Associated ◽  
Patient Demographics ◽  
Site Change ◽  
Inoculation Site ◽  
Group A ◽  
Echocardiographic Findings

Objective The present study was performed to identify factors associated with a Bacille Calmette–Guérin (BCG) inoculation site change in patients with Kawasaki disease (KD). Methods Among patients who had received BCG vaccination and treatment for KD at our hospital from 2005 through 2016, 177 patients born in 2005 through 2016 were enrolled. The patients were divided into those with (n = 83, change group) and without (n = 94, no-change group) a BCG site change, and the patient demographics, clinical severity, blood examination results, and echocardiographic findings were compared between the two groups. Results The change group was younger at onset and had a shorter interval from vaccination to onset. A BCG site change was observed in patients who developed the onset of KD symptoms from 31 to 806 days after BCG vaccination. Multivariate analysis showed that the interval from vaccination was closely and positively associated with the BCG site change (hazard ratio = 0.995, 95% confidence interval = 0.993–0.997). Conclusion A BCG site change in patients with KD is most closely associated with the interval from BCG vaccination to onset.

Sign in / Sign up

Export Citation Format

Share Document