A viral infection explanation for Kawasaki disease in general and for COVID-19 virus-related Kawasaki disease symptoms

Abstract An ordinary system of differential equations leading to a simulation model is propose as methodological approach to analysis the incidence of infectious-contagious diseases, in this case using SARS-CoV-2 virus as pathogenic model. The dynamics of the model are drive by the interaction between susceptible cells contemplating respiratory epithelial cells and viral infection mediated by two types of lysis response. To perform the simulations, values of some variables and parameters were selected from referenced sources, considering that previous reports suggested that the viral load in the lower respiratory tract might reach its peak in the second week after the beginning of disease symptoms. The scenarios described in the simulations evidence the performance of the cell lysis response from susceptible cells that have been infected. The recommend model shows that an excess response from both the original virus and the mutated virus leads to an increase in the approximate time to control viral infection within the organism.

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Abstract 76: Clinical Usefulness Of Serum Procalcionin Level In Kawasaki Disease Children.

Circulation ◽

10.1161/circ.131.suppl_2.76 ◽

2015 ◽

Vol 131 (suppl_2) ◽

Author(s):

Hee Joung Choi ◽

Tae Chan Kwon

Keyword(s):

Kawasaki Disease ◽

Bacterial Infection ◽

Viral Infection ◽

Systemic Inflammation ◽

Clinical Usefulness ◽

C Reactive Protein ◽

Acute Phase Reactants ◽

Reactive Protein ◽

Significant Difference ◽

Immunoglobulin Treatment

Purpose: Procalcitonin (PCT) is one of acute phase reactants such as C-reactive protein (CRP), and is likely to elevate in systemic inflammation, especially bacterial infection. As we know, the CRP level rise in the patients with high fever including Kawasaki disease (KD) and bacterial infection. So we investigated the clinical usefulness of serum PCT level in Kawasaki disease (KD), which is a systemic inflammation caused by vasculitis. Method: From August 2013 to June 2014, a total 336 patients were studied serum PCT level during hospitalization. We enrolled 41 patients of KD, 83 patients with viral infection, and 21 patients with bacterial infection. Result: The patients with KD had significantly higher mean age (24.4±18.1 months), mean body weight (12.1±3.9 Kg), and mean duration of fever prior to admission (4.4±1.8 days) than other patients (p<0.05). The serum PCT level, white blood cell (WBC) and platelet count, neutrophil proportion, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were significantly higher in KD patients than viral infection patients (p<0.05). Although not statistically significant, the serum PCT level was lower in KD patients than bacterial infection patients, whereas the CRP was higher in KD patients than bacterial infection patients. No significant difference in serum PCT level was showed between complete KD patients and incomplete KD patients. Also there was no significant difference in serum PCT level between responders to an initial intravenous immunoglobulin treatment and nonresponders. Conclusion: Serum PCT level may help to differentiate KD from viral infection, but we did not find a significant difference in PCT level between KD and bacterial infection. And the utility of PCT level as clinical marker in KD may be limited.

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Positive Serology for Dengue Viral Infection in Pediatric Patients With Kawasaki Disease in Southern Thailand

Circulation Journal ◽

10.1253/circj.cj-08-0158 ◽

2008 ◽

Vol 72 (9) ◽

pp. 1492-1494 ◽

Cited By ~ 7

Author(s):

Somkiat Sopontammarak ◽

Worakan Promphan ◽

Supaporn Roymanee ◽

Saranwan Phetpisan

Keyword(s):

Kawasaki Disease ◽

Viral Infection ◽

Pediatric Patients ◽

Positive Serology ◽

Southern Thailand

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Safety netting versus overtreatment in paediatrics: viral infection or incomplete Kawasaki disease?

BMJ Case Reports ◽

10.1136/bcr-2017-222323 ◽

2017 ◽

pp. bcr-2017-222323

Author(s):

Jennifer Michelle Charlesworth ◽

Bernadette Power ◽

Edina Moylett

Keyword(s):

Kawasaki Disease ◽

Viral Infection ◽

Incomplete Kawasaki Disease ◽

Safety Netting

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Identifying Circulating MicroRNA in Kawasaki Disease by Next-Generation Sequencing Approach

Current Issues in Molecular Biology ◽

10.3390/cimb43020037 ◽

2021 ◽

Vol 43 (2) ◽

pp. 485-500

Author(s):

Ken-Pen Weng ◽

Ching-Feng Cheng ◽

Kuang-Jen Chien ◽

Luo-Ping Ger ◽

Shih-Hui Huang ◽

...

Keyword(s):

Next Generation Sequencing ◽

Kawasaki Disease ◽

Viral Infection ◽

Intravenous Immunoglobulin ◽

Healthy Controls ◽

Next Generation ◽

Characteristic Analysis ◽

Expression Levels ◽

Potential Biomarker ◽

Generation Sequencing

Kawasaki disease (KD) typically occurs in children aged under 5 years and can cause coronary artery lesions (CALs). Early diagnosis and treatment with intravenous immunoglobulin can reduce the occurrence of CALs; therefore, identifying a good biomarker for diagnosing KD is essential. Here, using next-generation sequencing in patients with recurrent KD, those with viral infection, and healthy controls, we identified dysregulated circulating microRNAs as diagnostic biomarkers for KD. Pathway enrichment analysis illustrated the putative role of these miRNAs in KD progression. Their expression levels were validated using real-time polymerase chain reaction (qPCR). Fifteen dysregulated circulating miRNAs (fold changes >2 and <0.5) were differentially expressed in the recurrent KD group compared with the viral infection and control groups. These miRNAs were significantly involved in the transforming growth factor-β, epithelial–mesenchymal transition, and cell apoptosis signaling pathways. Notably, their expression levels were frequently restored after intravenous immunoglobulin treatment. Among the candidates, miR-24-3p expression level was significantly higher in patients with recurrent KD compared with healthy controls or viral infection controls (p < 0.001). Receiver operating characteristic analysis revealed that high miR-24-3p expression levels may be a potential biomarker for KD diagnosis. In conclusion, we identified miR-24-3p significantly higher in KD patients, which may be a potential diagnostic biomarker for KD.

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- KAWASAKI DISEASE AS THE IMMUNE-MEDIATED ECHO OF A VIRAL INFECTION

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2020.039 ◽

2020 ◽

Vol 12 (1) ◽

pp. e2020039

Author(s):

Donato Rigante

Keyword(s):

Kawasaki Disease ◽

Immune Responses ◽

Viral Infection ◽

Genetic Background ◽

Clinical Syndrome ◽

Infectious Agents ◽

Genetic Characteristics ◽

Immune Mediated

Although etiology of Kawasaki disease remains elusive, the available evidence indicates that the primum movens might be a dysregulation of immune responses to various microbes, i.e. a kind of immune-mediated response induced by a viral infection. Even if several data might suggest that Kawasaki disease is an infection-related clinical syndrome, which can develop only in children with a predisposing genetic background, our knowledge on both the infectious agents involved and the genetic characteristics of children prone to the disease remains poor.

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Metatranscriptomics and small RNA analysis revealed that viral covert coinfection resulted in disease symptoms reminiscent of rice sterility

10.21203/rs.3.rs-25471/v1 ◽

2020 ◽

Author(s):

Shufen Chao ◽

Haoran Wang ◽

Qing Yan ◽

Long Chen ◽

Guoqing Chen ◽

...

Keyword(s):

Viral Infection ◽

Small Rna ◽

Rna Viruses ◽

Brown Planthopper ◽

Crop Plants ◽

Disease Symptoms ◽

Rice Plants ◽

Rna Analysis ◽

Backcross Line ◽

Covert Infection

Abstract BackgroundViral pathogens are a major threat to stable crop production. The discovery of viral diseases traditionally concerns apparent infection that shows obvious symptoms in crop plants. However, little is known about the covert infection of crop plants by viruses. In this study, we used deep metatranscriptomic sequencing and small RNA analysis to identify covert infection of rice plants by viruses.ResultsOur results showed that introgression of the dominant brown planthopper (BPH) resistance gene Bph3 into the high-yielding but BPH-susceptible indica variety Ms55 via a backcross strategy significantly enhanced resistance to BPH. However, Bph3-carrying backcross lines infested by BPH exhibited panicle enclosure and failed to produce seed at the mature stage, which are typical characteristics of sterile rice plants. Using a metatranscriptomic analysis, we identified six RNA viruses in backcross line Rby1 and eleven RNA viruses in backcross line Rby2, including eight novel viruses that fell within existing families and orders. Furthermore, our small RNA analysis revealed the biogenesis of viral small interfering RNAs that represented active virus infection in rice plants.ConclusionBph3-carrying backcross rice lines are resistant to BPH but are susceptible to viral infection. We identified viral covert coinfection in sterile rice plants by deep metatranscriptomic sequencing and small RNA analysis. Our results suggested that covert coinfection of rice plants by RNA viruses resulted in disease symptoms reminiscent of rice sterility. To develop rice varieties resistant to BPH, it is necessary to introgress genes resistant to not only BPH but also viral infection.

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High-Throughput Screening of Kawasaki Disease Sera for Antiviral Antibodies

The Journal of Infectious Diseases ◽

10.1093/infdis/jiaa253 ◽

2020 ◽

Vol 222 (11) ◽

pp. 1853-1857 ◽

Cited By ~ 1

Author(s):

Daniel Quiat ◽

Tomasz Kula ◽

Chisato Shimizu ◽

John T Kanegaye ◽

Adriana H Tremoulet ◽

...

Keyword(s):

Kawasaki Disease ◽

Viral Infection ◽

Clinical Features ◽

High Throughput ◽

High Throughput Screening ◽

Protein Sequences ◽

Reference Protein ◽

Serologic Evidence ◽

Antiviral Antibody

Abstract Clinical features of Kawasaki disease (KD) display overlap with common pediatric viral illnesses, leading some to hypothesize that a viral infection is the inciting event for KD. To investigate viral infection history in KD patients, we performed comprehensive serological profiling using a high-throughput phage immunoprecipitation sequencing assay covering the complete reference protein sequences of known viruses with human tropism. KD and matched febrile control sera did not demonstrate differences in antiviral antibody profiles. We conclude that in the acute and subacute phases of disease, KD patients do not exhibit serologic evidence of exposure to known viruses that differs from controls.

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