Chondrosarcoma arising within a radiation-induced osteochondroma several years following childhood total body irradiation: Case report

2013 ◽  
Vol 42 (8) ◽  
pp. 1173-1177 ◽  
Author(s):  
Shuji Nagata ◽  
Robert K. Shen ◽  
Nadia N. Laack ◽  
Carrie Y. Inwards ◽  
Doris E. Wenger ◽  
...  
Keyword(s):  
Case Report ◽  
Total Body Irradiation ◽  
Radiation Induced ◽  
Total Body

Pulmonary toxicity following total body irradiation for acute lymphoblastic leukaemia: The Ottawa Hospital Cancer Centre (TOHCC) experience

2015 ◽  
Vol 15 (1) ◽  
pp. 54-60
Author(s):  
R. K. Ujaimi ◽  
N. Isfahanian ◽  
D. J. La Russa ◽  
R. Samant ◽  
C. Bredeson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Total Body Irradiation ◽  
Pulmonary Toxicity ◽  
Conditioning Regimen ◽  
Cancer Centre ◽  
Ottawa Hospital ◽  
Radiation Induced ◽  
Total Body

AbstractPurposeTo review the incidence of clinically significant pulmonary toxicity following total body irradiation (TBI) as a part of the conditioning regimen for acute lymphoblastic leukaemia (ALL) patients undergoing bone marrow transplantation (BMT) at The Ottawa Hospital Cancer Centre.MethodsThis is a retrospective review of ALL patients who received TBI in The Ottawa Hospital Bone Marrow Transplant Program (TOH-BMT) as part of their conditioning regimen from 1991 to 2011 inclusive. The patients were treated using a locally developed translating-couch irradiation technique. We have analysed all available data for the first 100 days following TBI to determine the incidence of radiation-induced pulmonary toxicities.ResultsOf the total 622 patients undergoing TBI during the specified period, 88 had ALL. Median age at BMT was 30 years and the conditioning regimens varied. A total of 74 (84%) patients received 12 Gy/6 F/BID of TBI. A total of 55 (63%) patients have died, 32 (36%) within the 1st year after BMT. In the 1st year, pulmonary events were reported for 24 (27%) patients, and the follow-up notes were unavailable for seven (8%). Pulmonary toxicities were reported as the cause of death for six patients, five (6%) within the 1st year. It is estimated that the total number of deaths in the 1st year possibly attributed to radiation-induced lung injury was four (4·5%). Eight (9%) patients had symptoms suggestive of non-lethal grade 2–3 radiation-induced pneumonitis.ConclusionsTBI continues to be an important component of the conditioning regimen for ALL patients undergoing BMT, and the incidence of radiation-induced pulmonary injury, using our technique and lung dose, is comparable to the published literature.

scholarly journals Radiation-induced bone sarcoma following total body irradiation: role of additional radiation on localized areas

2000 ◽  
Vol 25 (9) ◽  
pp. 1011-1013 ◽  
Author(s):  
YM Kirova ◽  
H Rafi ◽  
M-C Voisin ◽  
C Rieux ◽  
M Kuentz ◽  
...  
Keyword(s):  
Total Body Irradiation ◽  
Bone Sarcoma ◽  
Additional Radiation ◽  
Radiation Induced ◽  
Total Body

scholarly journals Multiple Osteochondromata after Total Body Irradiation: A Case Report.

2003 ◽  
Vol 52 (4) ◽  
pp. 720-723
Author(s):  
Takahiro Hamada ◽  
Ryohei Yokoyama ◽  
Naoyuki Kuga ◽  
Rin-ichiroi Sato ◽  
Yoshihisa Nagatoshi ◽  
...  
Keyword(s):  
Case Report ◽  
Total Body Irradiation ◽  
Total Body

scholarly journals Desoxyribonucleoprotein Thromboembolism Following Total Body Irradiation: Case Report

Blood ◽  
1960 ◽  
Vol 16 (5) ◽  
pp. 1629-1641
Author(s):  
ZDENEK HRUBAN ◽  
MILA I. PIERCE ◽  
SUMATI NAIR ◽  
NANCY E. WARNER
Keyword(s):  
Stem Cell ◽  
Case Report ◽  
Sudden Death ◽  
Total Body Irradiation ◽  
Cell Leukemia ◽  
Total Body ◽  
Stem Cell Leukemia

Abstract A case of sudden death shortly after total body radiation is reported in a patient with acute stem cell leukemia. The sudden death was associated with capillary DNA thromboembolism.

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