scholarly journals Impact of solitary pulmonary nodule size on qualitative and quantitative assessment using 18F-fluorodeoxyglucose PET/CT: the SPUTNIK trial

2020 ◽  
Author(s):  
J. R. Weir-McCall ◽  
◽  
S. Harris ◽  
K. A. Miles ◽  
N. R. Qureshi ◽  
...  
Keyword(s):  
Multicentre Trial ◽  
Pulmonary Nodules ◽  
Blood Pool ◽  
Qualitative Assessment ◽  
Solitary Pulmonary Nodules ◽  
Nodule Size ◽  
Diagnostic Threshold ◽  
Pet Ct ◽  
The Impact

Abstract Purpose To compare qualitative and semi-quantitative PET/CT criteria, and the impact of nodule size on the diagnosis of solitary pulmonary nodules in a prospective multicentre trial. Methods Patients with an SPN on CT ≥ 8 and ≤ 30 mm were recruited to the SPUTNIK trial at 16 sites accredited by the UK PET Core Lab. Qualitative assessment used a five-point ordinal PET-grade compared to the mediastinal blood pool, and a combined PET/CT grade using the CT features. Semi-quantitative measures included SUVmax of the nodule, and as an uptake ratio to the mediastinal blood pool (SURBLOOD) or liver (SURLIVER). The endpoints were diagnosis of lung cancer via biopsy/histology or completion of 2-year follow-up. Impact of nodule size was analysed by comparison between nodule size tertiles. Results Three hundred fifty-five participants completed PET/CT and 2-year follow-up, with 59% (209/355) malignant nodules. The AUCs of the three techniques were SUVmax 0.87 (95% CI 0.83;0.91); SURBLOOD 0.87 (95% CI 0.83; 0.91, p = 0.30 versus SUVmax); and SURLIVER 0.87 (95% CI 0.83; 0.91, p = 0.09 vs. SUVmax). The AUCs for all techniques remained stable across size tertiles (p > 0.1 for difference), although the optimal diagnostic threshold varied by size. For nodules < 12 mm, an SUVmax of 1.75 or visual uptake equal to the mediastinum yielded the highest accuracy. For nodules > 16 mm, an SUVmax ≥ 3.6 or visual PET uptake greater than the mediastinum was the most accurate. Conclusion In this multicentre trial, SUVmax was the most accurate technique for the diagnosis of solitary pulmonary nodules. Diagnostic thresholds should be altered according to nodule size. Trial registration ISRCTN - ISRCTN30784948. ClinicalTrials.gov - NCT02013063

Comparison of Quantitatively Analyzed Dynamic Area-Detector CT Using Various Mathematic Methods With FDG PET/CT in Management of Solitary Pulmonary Nodules

2013 ◽  
Vol 200 (6) ◽  
pp. W593-W602 ◽  
Author(s):  
Yoshiharu Ohno ◽  
Mizuho Nishio ◽  
Hisanobu Koyama ◽  
Yasuko Fujisawa ◽  
Takeshi Yoshikawa ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Area Detector ◽  
Pet Ct ◽  
Fdg Pet Ct

SHOULD WE BE CONCERNED ABOUT THE DOSES OF IONIZING RADIATION RELATED TO DIAGNOSTIC AND FOLLOW-UP IMAGING IN PATIENTS WITH SOLITARY PULMONARY NODULES?

2017 ◽  
Vol 178 (2) ◽  
pp. 201-207 ◽  
Author(s):  
Marta Dąbrowska ◽  
Zuzanna Przybyło ◽  
Małgorzata Żukowska ◽  
Małgorzata Kobylecka ◽  
Marta Maskey-Warzęchowska ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules

scholarly journals Dual time-point FDG PET-CT for differentiating benign from malignant solitary pulmonary nodules in a TB endemic area

2010 ◽  
Vol 100 (9) ◽  
pp. 598 ◽  
Author(s):  
Mike Machaba Sathekge ◽  
Alex Maes ◽  
Hans Pottel ◽  
Anton Stoltz ◽  
Christophe Van de Wiele
Keyword(s):  
Fdg Pet ◽  
Endemic Area ◽  
Pulmonary Nodules ◽  
Solitary Pulmonary Nodules ◽  
Pet Ct ◽  
Dual Time Point ◽  
Fdg Pet Ct ◽  
Time Point

scholarly journals Positive outcome in a high-grade myxofibrosarcoma: a case report

2018 ◽  
Vol 1 (1) ◽  
pp. 27-30
Author(s):  
Mihaela Olaru ◽  
Cornelia Nitipir
Keyword(s):  
Case Report ◽  
Fibrous Histiocytoma ◽  
Tumor Resection ◽  
Pulmonary Nodules ◽  
Positive Outcome ◽  
Pet Ct ◽  
Longus Muscle ◽  
Long Term Follow Up

AbstractMyxofibrosarcoma or myxoid malignant fibrous histiocytoma is one of the most common sarcomas of the limb. It is usually treated multimodally. Most frequent sites of metastasis are the bone, lung and lymph nodes. The present paper is a case report of a 65-year-old male with myxofibrosarcoma of the fibularis longus muscle, for which he first underwent surgery - tumor resection with appropriate margins. The tumor was staged pT2b cN0 cM0. Postoperative PET-CT revealed metabolically inactive pulmonary nodules. Two months after surgery, he underwent adjuvant radiotherapy, a total dose of 60 Gy and 6 courses of chemotherapy (doxorubicin and ifosfamide). Pulmonary nodules have been stationary on all subsequent imagistic studies. He is free of recurrence on long-term follow-up.

scholarly journals Evaluating the Impact of a brief Health at Every Size-Based activity on body positivity and internal weight-based oppression

2020 ◽  
Author(s):  
Hanaa Ahmed ◽  
Sana Elashie ◽  
Lily O'Hara
Keyword(s):  
Undergraduate Students ◽  
The Body ◽  
Body Image Disturbance ◽  
Qualitative Assessment ◽  
Body Appreciation ◽  
Self Reflection ◽  
Missing Responses ◽  
Health At Every Size ◽  
The Impact

Introduction: Internal weight-based oppression WBO is the internalized negative attitudes, values and beliefs people hold about body weight, and is associated with depression, anxiety, body image disturbance, disordered eating, avoidance of physical activity, and increased calorie consumption. Conversely, body positivity encompasses body acceptance, body appreciation, and body love, and adaptive approaches protective of health and wellbeing. The objective of the study was to evaluate the impact of the brief activity on body positivity and internal WBO in female students at Qatar University. Methods: The study used a quasi-experimental pre-post evaluation design, with quantitative assessment of body positivity and internal weight-based oppression before a brief activity (pre), immediately afterwards (post), and 10 weeks later (follow up), and qualitative assessment at the 10-week follow up. Love your Body, a Health at Every Size-based activity, was developed and delivered by public health students as part of the Mental Health Festival. The 10- minute activity involved Yay scales, positive affirmation stickers, photography, postcards, and gratitude writing. Evaluation measures used were the Body Appreciation Scale 2 (BAS-2), Modified Weight Bias Internalization Scale (M-WBIS), Fat Attitudes Assessment Toolkit Size Acceptance (FAAT-SA) and Self Reflection (FAAT-SR) subscales, and an open-ended questionnaire. Results: A total of 35 female undergraduate students completed assessments at all time points. Self-reflection and body appreciation increased significantly after the activity. All measures showed a trend towards improvement from pre to post assessment, but a return to baseline or near baseline status after 10 weeks. Qualitative results suggested that improvements were sustained at follow up. Conclusion: The activity had a positive effect on participants’ body appreciation and self-reflection in the short term, but these improvements were not sustained over the longer term. The high number of missing responses compromised the potential to determine findings that are more robust.

Impact of PSMA PET/CT on SRT planning: Preliminary results from the randomized phase III trial NCT03582774.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 30-30
Author(s):  
Jeremie Calais ◽  
Wesley R Armstrong ◽  
Amar Upadhyaya Kishan ◽  
Kiara M Booker ◽  
David Elashoff ◽  
...  
Keyword(s):  
Success Rate ◽  
Phase Iii ◽  
Open Label ◽  
Phase 3 ◽  
Preliminary Results ◽  
Volume Delineation ◽  
Psma Pet ◽  
Pet Ct ◽  
The Impact

30 Background: The purpose of this trial is to evaluate the success rate of salvage radiation therapy (SRT) for recurrence of prostate cancer (PCa) after radical prostatectomy with and without planning based on prostate specific membrane antigen (PSMA) positron emission tomography (PET). Methods: This is a multicenter, prospective, randomized, controlled, open-label, Phase 3 clinical imaging trial powered for clinical outcome at 5 years. UCLA is the leading central site in which PSMA PET, clinical follow-up and data management are being done. UCSF was a participating site in which PSMA PET imaging can be done. SRT can be performed anywhere, patients are followed remotely by the UCLA investigators. Patients scheduled for SRT for recurrence after primary prostatectomy and with PSA ≥ 0.1ng/ml at time of enrollment were eligible. Patients were randomized to proceed with standard SRT allowing for any conventional imaging aside from PSMA PET/CT (control arm) or undergo a 68Ga-PSMA-11 PET/CT scan prior to SRT planning (investigational arm). The primary endpoint is the success rate of SRT at 5 years in patients who undergo SRT. We report here the preliminary results of a secondary endpoint: the impact of PSMA PET on SRT planning by comparing the pre-randomization RT plans prospectively obtained on surveys before randomization to the actually delivered RT plans obtained after follow-up. Results: Enrollment of the trial was complete. 193 patients were enrolled from 09.06.2018 to 08.17.2020. 7/90 patients (9%) in the control arm dropped-out the study because they underwent a PSMA PET at another institution, while 1/103 (1%) patients of the intervention arm dropped-out due to COVID-19 related complications. After a median follow-up of 13.3 months (last follow-up date 09/01/2020), delivered RT plans were obtained in 60/83 (72%) and 70/102 (69%) of patients of the control and the PSMA arms, respectively. Median PSA at enrollment was 0.32 ng/ml (IQR 0.17-1.35) and 0.22 ng/ml (IQR 0.14-0.50) in the control and PSMA arms, respectively. There was a change between the intended pre-randomization RT plan and the actually delivered RT plan in 17/60 (28%) and 40/70 (57%) of the patients in the control and PSMA arms, respectively (p = 0.002). SRT was aborted in favor of systemic therapy and/or metastasis directed RT for extra-pelvic M1 disease in 2/60 (3%) and 12/70 (17%) of the control and PSMA arms, respectively (p = 0.17). Dose prescription and/or target volume delineation was changed in 2/60 (3%) and 1/70 (26%) in the control and PSMA arms, respectively (p = 0.001). Conclusions: In this prospective randomized phase 3 study, PSMA PET had an impact on the SRT plan in more than half of the patients. Long-term follow-up will show if the impact of PSMA PET on SRT planning translates into improved outcome or not. Clinical trial information: NCT03582774.

Diagnostic value of 18F-FDG-PET/CT for the evaluation of solitary pulmonary nodules

2017 ◽  
Vol 38 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Zong Ruilong ◽  
Xie Daohai ◽  
Geng Li ◽  
Wang Xiaohong ◽  
Wang Chunjie ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Pulmonary Nodules ◽  
Diagnostic Value ◽  
Solitary Pulmonary Nodules ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Evaluation of FDG-PET/CT Use in Children with Suspected Infection or Inflammation

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 715
Author(s):  
Fabienne G. Ropers ◽  
Robin M. P. van Mossevelde ◽  
Chantal P. Bleeker-Rovers ◽  
Floris H. P. van Velden ◽  
Danielle M. E. van Assema ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Final Diagnosis ◽  
Management Decisions ◽  
Multicenter Cohort Study ◽  
Disease Manifestation ◽  
Suspected Infection ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
The Impact

[18F]-FDG-PET/CT ([18F]-fluoro-deoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)) is increasingly used as a diagnostic tool in suspected infectious or inflammatory conditions. Studies on the value of FDG-PET/CT in children are scarce. This study assesses the role of FDG-PET/CT in suspected infection or inflammation in children. In this multicenter cohort study, 64 scans in 59 children with suspected infection or inflammation were selected from 452 pediatric FDG-PET/CT scans, performed in five hospitals between January 2016 and August 2017. Main outcomes were diagnostic information provided by FDG-PET/CT for diagnostic scans and impact on clinical management for follow-up scans. Of these 64 scans, 50 were performed for primary diagnosis and 14 to monitor disease activity. Of the positive diagnostic scans, 23/27 (85%) contributed to establishing a diagnosis. Of the negative diagnostic scans, 8/21 (38%) contributed to the final diagnosis by narrowing the differential or by providing information on the disease manifestation. In all follow-up scans, FDG-PET/CT results guided management decisions. CRP was significantly higher in positive scans than in negative scans (p = 0.004). In 6% of diagnostic scans, relevant incidental findings were identified. In conclusion, FDG-PET/CT performed in children with suspected infection or inflammation resulted in information that contributed to the final diagnosis or helped to guide management decisions in the majority of cases. Prospective studies assessing the impact of FDG-PET/CT results on diagnosis and patient management using a structured diagnostic protocol are feasible and necessary.

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