Non-invasive assessment of mesenteric hemodynamics in patients with suspected chronic mesenteric ischemia using 4D flow MRI

Background Four-dimensional flow magnetic resonance imaging (4D flow MRI) provides volumetric and time-resolved visualization and quantification of blood flow. This review presents an overview of possible applications of 4D flow MRI for non-invasive assessment of abdominal hemodynamics. Method This review is based on the authors’ experience and the current literature. A PubMed database literature research was performed in December 2019 focusing on abdominal applications of 4D flow MRI. We illustrated the review with exemplary figures and movies of clinical cases from our institution. Results and Conclusion 4D flow MRI offers the possibility of comprehensive assessment of abdominal blood flows in different vascular territories and organ systems. Results of recent studies indicate that 4D flow MRI improves understanding of altered hemodynamics in patients with abdominal disease and may be useful for monitoring therapeutic response. Future studies with larger cohorts aiming to integrate 4D flow MRI in the clinical routine setting are needed. Key Points: Citation Format

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Assessing cerebral arterial pulse wave velocity using 4D flow MRI

Journal of Cerebral Blood Flow & Metabolism ◽

10.1177/0271678x211008744 ◽

2021 ◽

pp. 0271678X2110087

Author(s):

Cecilia Björnfot ◽

Anders Garpebring ◽

Sara Qvarlander ◽

Jan Malm ◽

Anders Eklund ◽

...

Keyword(s):

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Systolic Pressure ◽

Vascular Tree ◽

4D Flow Mri ◽

4D Flow ◽

Non Invasive ◽

Age Related ◽

Flow Mri

Intracranial arterial stiffening is a potential early marker of emerging cerebrovascular dysfunction and could be mechanistically involved in disease processes detrimental to brain function via several pathways. A prominent consequence of arterial wall stiffening is the increased velocity at which the systolic pressure pulse wave propagates through the vasculature. Previous non-invasive measurements of the pulse wave propagation have been performed on the aorta or extracranial arteries with results linking increased pulse wave velocity to brain pathology. However, there is a lack of intracranial “target-organ” measurements. Here we present a 4D flow MRI method to estimate pulse wave velocity in the intracranial vascular tree. The method utilizes the full detectable branching structure of the cerebral vascular tree in an optimization framework that exploits small temporal shifts that exists between waveforms sampled at varying depths in the vasculature. The method is shown to be stable in an internal consistency test, and of sufficient sensitivity to robustly detect age-related increases in intracranial pulse wave velocity.

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Non-invasive local pulse wave velocity using 4D-flow MRI

Biomedical Signal Processing and Control ◽

10.1016/j.bspc.2021.103259 ◽

2022 ◽

Vol 71 ◽

pp. 103259

Author(s):

Joaquín Mura ◽

Julio Sotelo ◽

Hernán Mella ◽

James Wong ◽

Tarique Hussain ◽

...

Keyword(s):

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

4D Flow Mri ◽

4D Flow ◽

Non Invasive ◽

Flow Mri

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4D-Flow MRI: Beyond the Images

Seminars in Thoracic and Cardiovascular Surgery ◽

10.1053/j.semtcvs.2019.09.008 ◽

2020 ◽

Vol 32 (1) ◽

pp. 35

Author(s):

Pietro Sergio ◽

Antonio Miceli

Keyword(s):

4D Flow Mri ◽

4D Flow ◽

Flow Mri

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4D- Flow- MRI After Aortic Valve Surgery

Case Medical Research ◽

10.31525/ct1-nct04223713 ◽

2020 ◽

Author(s):

Keyword(s):

Aortic Valve ◽

Valve Surgery ◽

Aortic Valve Surgery ◽

4D Flow Mri ◽

4D Flow ◽

Flow Mri

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Circulation derived from 4D flow MRI correlates with right ventricular dysfunction in patients with tetralogy of Fallot

Scientific Reports ◽

10.1038/s41598-021-91125-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Nanae Tsuchiya ◽

Michinobu Nagao ◽

Yumi Shiina ◽

Shohei Miyazaki ◽

Kei Inai ◽

...

Keyword(s):

Right Ventricular ◽

Tetralogy Of Fallot ◽

Main Pulmonary Artery ◽

Vortex Formation ◽

Cine Mri ◽

Short Axis ◽

4D Flow Mri ◽

4D Flow ◽

Flow Mri ◽

Rv Function

AbstractWe used 4D-flow MRI to investigate circulation, an area integral of vorticity, in the main pulmonary artery (MPA) as a new hemodynamic parameter for assessing patients with a repaired Tetralogy of Fallot (TOF). We evaluated the relationship between circulation, right ventricular (RV) function and the pulmonary regurgitant fraction (PRF). Twenty patients with a repaired TOF underwent cardiac MRI. Flow-sensitive 3D-gradient sequences were used to obtain 4D-flow images. Vortex formation in the MPA was visualized, with short-axis and longitudinal vorticities calculated by software specialized for 4D flow. The RV indexed end-diastolic/end-systolic volumes (RVEDVi/RVESVi) and RV ejection fraction (RVEF) were measured by cine MRI. The PR fraction (PRF) and MPA area were measured by 2D phase-contrast MRI. Spearman ρ values were determined to assess the relationships between circulation, RV function, and PRF. Vortex formation in the MPA occurred in 15 of 20 patients (75%). The longitudinal circulation (11.7 ± 5.1 m2/s) was correlated with the RVEF (ρ = − 0.85, p = 0.0002), RVEDVi (ρ = 0.62, p = 0.03), and RVESVi (ρ = 0.76, p = 0.003) after adjusting for the MPA size. The short-axis circulation (9.4 ± 3.4 m2/s) in the proximal MPA was positively correlated with the MPA area (ρ = 0.61, p = 0.004). The relationships between the PRF and circulation or RV function were not significant. Increased longitudinal circulation in the MPA, as demonstrated by circulation analysis using 4D flow MRI, was related to RV dysfunction in patients with a repaired TOF.

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