Role of Pancreatic Juice Cytology in the Preoperative Management of Intraductal Papillary Mucinous Neoplasm of the Pancreas in the Era of International Consensus Guidelines 2012

2014 ◽  
Vol 38 (11) ◽  
pp. 2994-3001 ◽  
Author(s):  
Takao Ohtsuka ◽  
Taketo Matsunaga ◽  
Hideyo Kimura ◽  
Yusuke Watanabe ◽  
Koji Tamura ◽  
...  
Keyword(s):  
Pancreatic Juice ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Consensus Guidelines ◽  
Preoperative Management ◽  
International Consensus ◽  
Mucinous Neoplasm ◽  
Pancreatic Juice Cytology ◽  
International Consensus Guidelines

scholarly journals Should Contrast-Enhanced Harmonic Endoscopic Ultrasound Be Incorporated into the International Consensus Guidelines to Determine the Appropriate Treatment of Intraductal Papillary Mucinous Neoplasm?

2021 ◽  
Vol 10 (9) ◽  
pp. 1818
Author(s):  
Tomohiro Yamazaki ◽  
Mamoru Takenaka ◽  
Shunsuke Omoto ◽  
Tomoe Yoshikawa ◽  
Rei Ishikawa ◽  
...  
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Predictive Value ◽  
Diagnostic Value ◽  
Consensus Guidelines ◽  
International Consensus ◽  
Mucinous Neoplasm ◽  
Appropriate Treatment ◽  
Contrast Enhanced ◽  
Diagnostic Values ◽  
International Consensus Guidelines

This study aimed to investigate whether the incorporation of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) into the international consensus guidelines (ICG) for the management of intraductal papillary mucinous neoplasm (IPMN) could improve its malignancy diagnostic value. In this single-center retrospective study, 109 patients diagnosed with IPMN who underwent preoperative CH-EUS between March 2010 and December 2018 were enrolled. We analyzed each malignancy diagnostic value (sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV)) by replacing fundamental B-mode EUS with CH-EUS as the recommended test for patients with worrisome features (WF) (the CH-EUS incorporation ICG) and comparing the results to those obtained using the 2017 ICG. The malignancy diagnostic values as per the 2017 ICG were 78.9%, 42.3%, 60.0%, and 64.7% for Se, Sp, PPV, and NPV, respectively. The CH-EUS incorporation ICG plan improved the malignancy diagnostic values (Se 78.9%/Sp, 53.8%/PPV, 65.2%/NPV 70.0%). CH-EUS may be useful in determining the appropriate treatment strategies for IPMN.

scholarly journals The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Kazuya Miyamoto ◽  
Kazuyuki Matsumoto ◽  
Hironari Kato ◽  
Ryuichi Yoshida ◽  
Yuzo Umeda ◽  
...  
Keyword(s):  
Pancreatic Juice ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Low Grade ◽  
Cell Recovery ◽  
International Consensus ◽  
Mucinous Neoplasm ◽  
Liquid Based Cytology ◽  
Pancreatic Juice Cytology ◽  
Almost All ◽  
Malignant Ipmn

Abstract Background Pancreatic juice cytology (PJC) is a tool for diagnosing malignant intraductal papillary mucinous neoplasm (IPMN); however, the accuracy is insufficient using the conventional method. Liquid-based cytology (LBC) improves the cell recovery rate, and almost all cells can be evaluated. We evaluated the efficacy of PJC with LBC for malignant IPMN. Methods We retrospectively analyzed 90 patients with suspected malignant IPMN who underwent PJC before pancreatectomy. PJC with smear and LBC methods was conducted in 52 patients (between June 2003 to December 2011) and 38 patients (between January 2012 to December 2018). Based on the imaging studies, all of the patients were classified according to the international consensus guidelines for IPMN revised in 2017. Results Of the 90 patients, 43 (48%) had malignant IPMN (high-grade dysplasia or invasive carcinoma), and the remaining patients had non-malignant IPMN (intermediate- or low-grade dysplasia). LBC increased the accuracy of PJC for the diagnosis of malignant IPMN (smear method: 56% [29/52] vs. LBC method: 76% [29/38]; P = 0.044). In a multivariate analysis, LBC was a significant factor influencing the accurate diagnosis of PJC (odds ratio: 3.52; P = 0.021). Furthermore, LBC increased the accuracy of PJC for malignant IPMN in patients with worrisome features (smear method: 66% [19/29] vs. LBC method: 93% [14/15]; P = 0.043). Conclusions LBC increases the accuracy of PJC for diagnosing malignant IPMN compared with the conventional smear method.

scholarly journals The role of pancreatic juice cytology in the diagnosis of pancreatic intraductal papillary mucinous neoplasm

2018 ◽  
Vol 111 ◽  
Author(s):  
Mohammed Tag-Adeen ◽  
Eisuke Ozawa ◽  
Kumi Ogihara ◽  
Shinichi Iwatsu ◽  
Yuko Akazawa ◽  
...  
Keyword(s):  
Pancreatic Juice ◽  
Intraductal Papillary Mucinous Neoplasm ◽  
Mucinous Neoplasm ◽  
Pancreatic Juice Cytology
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