Enhancement of cisplatin sensitivity by NSC109268 in budding yeast and human cancer cells is associated with inhibition of S-phase progression

2010 ◽  
Vol 66 (5) ◽  
pp. 945-952 ◽  
Author(s):  
Dilip Jain ◽  
Nila Patel ◽  
Melanie Shelton ◽  
Alakananda Basu ◽  
Rouel Roque ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Budding Yeast ◽  
Human Cancer ◽  
S Phase ◽  
Human Cancer Cells ◽  
Cisplatin Sensitivity ◽  
Phase Progression

Comparisons of the Frequencies and Molecular Spectra of HPRT Mutants When Human Cancer Cells Were X-Irradiated during G 1 or S Phase

1997 ◽  
Vol 148 (6) ◽  
pp. 548 ◽  
Author(s):  
Edith A. Leonhardt ◽  
Maxine Trinh ◽  
Helen B. Forrester ◽  
Robert T. Johnson ◽  
William C. Dewey
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
S Phase ◽  
Molecular Spectra ◽  
Human Cancer Cells

New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells

Biochimie ◽  
2011 ◽  
Vol 93 (6) ◽  
pp. 1065-1075 ◽  
Author(s):  
Rita C. Santos ◽  
Jorge A.R. Salvador ◽  
Roldán Cortés ◽  
Gisela Pachón ◽  
Silvia Marín ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Betulinic Acid ◽  
Human Cancer ◽  
S Phase ◽  
Human Cancer Cells ◽  
Cycle Arrest

scholarly journals Dormant replication origin firing links replication stress to whole chromosomal instability in human cancer

2021 ◽  
Author(s):  
Ann-Kathrin Schmidt ◽  
Nicolas Boehly ◽  
Xiaoxiao Zhang ◽  
Benjamin O. Slusarenko ◽  
Magdalena Hennecke ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Chromosomal Instability ◽  
Replication Origin ◽  
Human Cancer ◽  
Chromosome Instability ◽  
Replication Stress ◽  
S Phase ◽  
Origin Firing ◽  
Human Cancer Cells ◽  
Chromosome Missegregation

Chromosomal instability (CIN) is a hallmark of cancer and comprises structural CIN (S-CIN) and whole chromosome instability (W-CIN). Replication stress (RS), a condition of slowed or stalled DNA replication during S phase, has been linked to S-CIN, whereas defects in mitosis leading to chromosome missegregation and aneuploidy can account for W-CIN. It is well established that RS can activate additional replication origin firing that is considered as a rescue mechanism to suppress chromosomal instability in the presence of RS. In contrast, we show here that an increase in replication origin firing during S phase can contribute to W-CIN in human cancer cells. Increased origin firing can be specifically triggered by overexpression of origin firing genes including GINS1 and CDC45, whose elevated expression significantly correlates with W-CIN in human cancer specimens. Moreover, endogenous mild RS present in cancer cells characterized by W-CIN or modulation of the origin firing regulating ATR-CDK1-RIF1 axis induces dormant origin firing, which is sufficient to trigger chromosome missegregation and W-CIN. Importantly, chromosome missegregation upon increased dormant origin firing is mediated by increased microtubule growth rates leading to the generation of lagging chromosomes in mitosis, a condition prevalent in chromosomally unstable cancer cells. Thus, our study identified increased or dormant replication origin firing as a hitherto unrecognized, but cancer-relevant trigger for chromosomal instability.

scholarly journals Inhibition of Rac1 activity induces G1/S phase arrest through the GSK3/cyclin D1 pathway in human cancer cells

2014 ◽  
Vol 32 (4) ◽  
pp. 1395-1400 ◽  
Author(s):  
LINNA LIU ◽  
HONGMEI ZHANG ◽  
LEI SHI ◽  
WENJUAN ZHANG ◽  
JUANLI YUAN ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Cancer Cells ◽  
Human Cancer ◽  
S Phase ◽  
Human Cancer Cells ◽  
Phase Arrest ◽  
Rac1 Activity ◽  
S Phase Arrest

scholarly journals Replication Stress, Defective S-phase Checkpoint and Increased Death in Plk2-Deficient Human Cancer Cells

Cell Cycle ◽  
2007 ◽  
Vol 6 (20) ◽  
pp. 2571-2578 ◽  
Author(s):  
Elizabeth M. Matthew ◽  
Timothy J. Yen ◽  
David T. Dicker ◽  
Jay F. Dorsey ◽  
Wensheng Yang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Replication Stress ◽  
S Phase ◽  
Human Cancer Cells ◽  
S Phase Checkpoint

scholarly journals Targeting phosphodiesterase 3 B enhances cisplatin sensitivity in human cancer cells

2013 ◽  
Vol 2 (1) ◽  
pp. 40-49 ◽  
Author(s):  
Katsuhiro Uzawa ◽  
Atsushi Kasamatsu ◽  
Takao Baba ◽  
Katsuya Usukura ◽  
Yasuhiro Saito ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Phosphodiesterase 3 ◽  
Cisplatin Sensitivity

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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