Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen

2000 ◽  
Vol 46 (6) ◽  
pp. 507-516 ◽  
Author(s):  
Pietro Taverna ◽  
Lili Liu ◽  
Amy J. Hanson ◽  
Anne Monks ◽  
Stanton L. Gerson
Keyword(s):  
Mismatch Repair ◽  
Cell Lines ◽  
Anticancer Drug ◽  
Dna Mismatch Repair ◽  
Drug Screen ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

Characterization of the DNA mismatch repair proteins MutS and MutL in a hypermutator Acinetobacter baumannii

2017 ◽  
Vol 113 ◽  
pp. 74-84 ◽  
Author(s):  
Behnaz Deihim ◽  
Malihe Hassanzadeh ◽  
Nazanin Zahra Shafiei-Jandaghi ◽  
Massoud Amanlou ◽  
Masoumeh Douraghi
Keyword(s):  
Acinetobacter Baumannii ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

scholarly journals LncRNA-XIST interacts with miR-29c to modulate the chemoresistance of glioma cell to TMZ through DNA mismatch repair pathway

2017 ◽  
Vol 37 (5) ◽  
Author(s):  
Peng Du ◽  
Haiting Zhao ◽  
Renjun Peng ◽  
Qing Liu ◽  
Jian Yuan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mismatch Repair ◽  
Cell Lines ◽  
Glioma Cell ◽  
Dna Mismatch Repair ◽  
Tumor Biology ◽  
Glioma Cells ◽  
Dna Mismatch ◽  
Cell Proliferation Inhibition ◽  
Glioma Cell Lines

Temozolomide (TMZ) is the most commonly used alkylating agent in glioma chemotherapy. However, growing resistance to TMZ remains a major challenge for clinicians. Recent evidence emphasizes the key regulatory roles of non-coding RNAs (lncRNAs and miRNAs) in tumor biology, including the chemoresistance of cancers. However, little is known about the role and regulation mechanisms of lncRNA cancer X-inactive specific transcripts (XIST) in glioma tumorigenesis and chemotherapy resistance. In the present study, higher XIST expression was observed in glioma tissues and cell lines, which was related to poorer clinicopathologic features and shorter survival time. XIST knockdown alone was sufficient to inhibit glioma cell proliferation and to amplify TMZ-induced cell proliferation inhibition. Moreover, XIST knockdown can sensitize TMZ-resistant glioma cells to TMZ. XIST can inhibit miR-29c expression by directly targetting TMZ-resistant glioma cells. DNA repair protein O6-methylguanine-DNA methytransferase (MGMT) plays a key role in TMZ resistance; transcription factor specificity protein 1 (SP1), a regulator of DNA mismatch repair (MMR) key protein MSH6, has been reported to be up-regulated in TMZ-resistant glioma cell lines. In the present study, we show that XIST/miR-29c coregulates SP1 and MGMT expression in TMZ-resistant glioma cell lines. Our data suggest that XIST can amplify the chemoresistance of glioma cell lines to TMZ through directly targetting miR-29c via SP1 and MGMT. XIST/miR-29c may be a potential therapeutic target for glioma treatment.

scholarly journals Helicobacter pylori infection and expression of DNA mismatch repair proteins

2008 ◽  
Vol 14 (43) ◽  
pp. 6717 ◽  
Author(s):  
Vahid Mirzaee ◽  
Mahsa Molaei ◽  
Hamid Mohaghegh Shalmani ◽  
Mohammad Reza Zali
Keyword(s):  
Helicobacter Pylori ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Helicobacter Pylori Infection ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

scholarly journals Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX

Oncogene ◽  
2003 ◽  
Vol 22 (6) ◽  
pp. 819-825 ◽  
Author(s):  
Mary Mac Partlin ◽  
Elizabeth Homer ◽  
Helen Robinson ◽  
Carol J McCormick ◽  
Dorothy H Crouch ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins

Clinical characterization of DNA mismatch repair deficiency (MMR-D) in endometrial cancer (EC).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 1522-1522
Author(s):  
Karen Anne Cadoo ◽  
Christina Tran ◽  
Deborah DeLair ◽  
Angela G. Arnold ◽  
Asad Ashraf ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Mismatch Repair Deficiency ◽  
Dna Mismatch ◽  
Repair Deficiency ◽  
Dna Mismatch Repair Deficiency

Characterization of clinically aggressive meningiomas by mutational signatures associated with DNA mismatch repair and aging.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e14044-e14044
Author(s):  
Sylvia Christine Kurz ◽  
Stephen Kelly ◽  
Varshini Vasudevaraja ◽  
Benjamin Liechty ◽  
Ramona Bledea ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Mutational Signatures ◽  
Dna Mismatch

scholarly journals C-Terminal Fluorescent Labeling Impairs Functionality of DNA Mismatch Repair Proteins

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31863 ◽  
Author(s):  
Angela Brieger ◽  
Guido Plotz ◽  
Inga Hinrichsen ◽  
Sandra Passmann ◽  
Ronja Adam ◽  
...  
Keyword(s):  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Fluorescent Labeling ◽  
Dna Mismatch ◽  
Mismatch Repair Proteins
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