Differentiation of low- and high-grade pediatric gliomas with amide proton transfer imaging: added value beyond quantitative relaxation times

2021 ◽  
Author(s):  
Hongxi Zhang ◽  
Xingwang Yong ◽  
Xiaohui Ma ◽  
Jianjiang Zhao ◽  
Zhipeng Shen ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Relaxation Times ◽  
Added Value ◽  
Amide Proton ◽  
High Grade ◽  
Amide Proton Transfer ◽  
Amide Proton Transfer Imaging

scholarly journals Amide proton transfer imaging might predict survival and IDH mutation status in high-grade glioma

2019 ◽  
Vol 29 (12) ◽  
pp. 6643-6652 ◽  
Author(s):  
Bio Joo ◽  
Kyunghwa Han ◽  
Sung Soo Ahn ◽  
Yoon Seong Choi ◽  
Jong Hee Chang ◽  
...  
Keyword(s):  
Proton Transfer ◽  
High Grade Glioma ◽  
Amide Proton ◽  
High Grade ◽  
Idh Mutation ◽  
Mutation Status ◽  
Amide Proton Transfer ◽  
Amide Proton Transfer Imaging

Amide proton transfer imaging for differentiation of tuberculomas from high-grade gliomas: Preliminary experience

2021 ◽  
pp. 197140092110027
Author(s):  
Karthik Kulanthaivelu ◽  
Shumyla Jabeen ◽  
Jitender Saini ◽  
Sanita Raju ◽  
Atchayaram Nalini ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Chemical Exchange ◽  
Spin Echo ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
High Grade ◽  
Saturation Pulse ◽  
Amide Proton Transfer ◽  
High Grade Gliomas ◽  
Amide Protons

Purpose Tuberculomas can occasionally masquerade as high-grade gliomas (HGG). Evidence from magnetisation transfer (MT) imaging suggests that there is lower protein content in the tuberculoma microenvironment. Building on the principles of chemical exchange saturation transfer and MT, amide proton transfer (APT) imaging generates tissue contrast as a function of the mobile amide protons in tissue’s native peptides and intracellular proteins. This study aimed to further the understanding of tuberculomas using APT and to compare it with HGG. Method Twenty-two patients ( n = 8 tuberculoma; n = 14 HGG) were included in the study. APT was a 3D turbo spin-echo Dixon sequence with inbuilt B0 correction. A two-second, 2 μT saturation pulse alternating over transmit channels was applied at ±3.5 ppm around water resonance. The APT-weighted image (APTw) was computed as the MT ratio asymmetry (MTRasym) at 3.5 ppm. Mean MTRasym values in regions of interest (areas = 9 mm2; positioned in component with homogeneous enhancement/least apparent diffusion coefficient) were used for the analysis. Results MTRasym values of tuberculomas ( n = 14; 8 cases) ranged from 1.34% to 3.11% ( M = 2.32 ± 0.50). HGG ( n = 17;14 cases) showed MTRasym ranging from 2.40% to 5.70% ( M = 4.32 ± 0.84). The inter-group difference in MTRasym was statistically significant ( p < 0.001). APTw images in tuberculomas were notable for high MTRasym values in the perilesional oedematous-appearing parenchyma (compared to contralateral white matter; p < 0.001). Conclusion Tuberculomas demonstrate lower MTRasym ratios compared to HGG, reflective of a relative paucity of mobile amide protons in the ambient microenvironment. Elevated MTRasym values in perilesional parenchyma in tuberculomas are a unique observation that may be a clue to the inflammatory milieu.

Quantitative Analysis of Mobile Proteins in Normal Brain Tissue by Amide Proton Transfer Imaging

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Kazuaki Sugawara ◽  
Tosiaki Miyati ◽  
Ryo Ueda ◽  
Daisuke Yoshimaru ◽  
Masanobu Nakamura ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Proton Transfer ◽  
Brain Tissue ◽  
Amide Proton ◽  
Normal Brain ◽  
Normal Brain Tissue ◽  
Amide Proton Transfer ◽  
Amide Proton Transfer Imaging

Chapter 15 Principles and Applications of Amide Proton Transfer Imaging

2017 ◽  
pp. 345-376
Author(s):  
Jinyuan Zhou ◽  
Yi Zhang ◽  
Shanshan Jiang ◽  
Dong-Hoon Lee ◽  
Xuna Zhao ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Amide Proton Transfer Imaging
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